Oxygenated perfluorocarbon, recombinant human superoxide dismutase, and catalase ameliorate free radical induced myocardial injury during heart preservation and transplantation

Twenty-Four Hours Postoperative Results After Orthotopic Cardiac Transplantation in Swine

“…Experimental orthotopic heart transplantations are most frequently carried out in dogs, sheep, or primates. [4][5][6] At present, the importance of the pig heart as an object of transplantation research is increasing, because swine share anatomic and physiologic characteristics with man, which have enabled them to become valuable models in cardiovascular surgery. 7,8 It was the aim of this study to measure functional and morphological parameters in a porcine orthotopic heart transplantation model after a certain observation time.…”

The effect of coronary perfusion with an oxygenated celsior solution on 12-hour cardiac preservation

“…R has been reported that perfusion preservation with an oxygenated solution, or a perfusate containing an oxygen carrier, is effective for long-term organ preservation [1,2,5,6,8,23]. Bando and co-workers [23] postulated that the maintenance of myocardial oxygenation with an oxygenated solution eliminated or reduced the oxygen free radical-mediated functional depression that occurred after prolonged hypothermic preservation. It seems as though basic metabolism continues at a minimal rate, even under hypothermic conditions, and when oxygen is administered, aerobic glycolysis produces high-energy phosphates.…”

Donor left ventricular hypertrophy increases risk for early graft failure

“…The association between cardiac dysfunction and intracranial hemorrhage is well established. A number of studies have reported the association between subarachnoid hemorrhage and subendocardial necrosis [2,4,71. In this study, the incidence of early graft dysfunction did not correlate with the etiology of death of the donor.…”