Oxygen utilization and coronary vascular reserve in the ischemic myocardium following acute coronary occlusion in the dog

Grayson, J.; Scott, C.; Morrison, C.J.

doi:10.1016/0026-2862(76)90050-9

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…These values could be increased by catecholamine infusion or by ligation of a coronary artery. In the tissue affected by the ligation we have 0022-3751/80/2640-0182 $07.50 © 1980 The Physiological Society occasionally obtained oxygen extraction ratios in excess of 90% (Grayson, Scott & Morrison, 1976).…”

Section: Introductionmentioning

confidence: 93%

The effect of adrenaline and noradrenaline on coronary vascular reserve in the dog.

Creates¹,

Grayson²

1980

The Journal of Physiology

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SUMMARY1. Experiments were performed on dogs, anaesthetized with pentobarbitone sodium to measure the oxygen utilization of anterior ventricular wall. The anterior interventricular vein was used for venous blood collection and flow measurement.2. Oxygen contents of arterial blood and coronary vein were measured. 3. Intravenous (femoral vein) adrenaline infusions raised arterial blood pressure and caused an initial fall in oxygen extraction from control values of 67-45%. Noradrenaline caused an initial fall from 67 to 51%. With both, the oxygen extraction began to rise during the infusion and continued, reaching maximum levels, (mean--82%) 10 min after start of infusion. The range of maximum values for oxygen extraction ratio after noradrenaline was 76-95%.4. An inverse linear relation was established between blood pressure and oxygen extraction; whereas a direct linear relationship was established between coronary venous blood flow and mean arterial pressure.5. When a change in blood pressure was prevented, the oxygen extraction ratio rose. 6. In all experiments, whether extraction rose or fell, the oxygen consumption rose. 7. It is suggested that oxygen extraction is a controlled variable and, with coronary blood flow, contributes quantitatively to coronary vascular reserve.8. The tension-time index was not directly related to oxygen consumption in these experiments. Oxygen consumption rose in response to catecholamines by about the same amount even when mean arterial blood pressure was controlled. It is suggested that cardiac adjustments to altered afterload may also involve alterations in mechanical efficiency.

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Section: Introductionmentioning

confidence: 93%

The effect of adrenaline and noradrenaline on coronary vascular reserve in the dog.

Creates¹,

Grayson²

1980

The Journal of Physiology

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Influence of initial reperfusion pressure after hypothermic cardioplegic ischemia on endothelial modulation of coronary tone in neonatal lambs

Sawatari

Kadoba

Bergner

et al. 1991

The Journal of Thoracic and Cardiovascular Surgery

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Regional blood flow, oxidative metabolism, and glucose utilization in patients with recent myocardial infarction.

Czernin¹,

Porenta²,

Brunken³

et al. 1993

Circulation

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Quantification of regional blood flow and substrate metabolism in postinfarction patients revealed alterations in the relation between substrate delivery and consumption demonstrated previously only in invasive animal experiments. The preserved oxidative metabolism in myocardium with PET mismatches may be ascribed to a regional increase in oxygen extraction. Such increase together with preserved glucose utilization may be the prerequisite for survival of ischemically injured myocardium.

show abstract

Oxygen utilization and coronary vascular reserve in the ischemic myocardium following acute coronary occlusion in the dog

Cited by 3 publications

References 19 publications

The effect of adrenaline and noradrenaline on coronary vascular reserve in the dog.

The effect of adrenaline and noradrenaline on coronary vascular reserve in the dog.

Influence of initial reperfusion pressure after hypothermic cardioplegic ischemia on endothelial modulation of coronary tone in neonatal lambs

Regional blood flow, oxidative metabolism, and glucose utilization in patients with recent myocardial infarction.

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