Oxygen uptake transient kinetics during constant-load exercise in children after operations of ventricular septal defect, tetralogy of Fallot, transposition of the great arteries, or tricuspid valve atresia

Exercise Studies in Patients with Transposition of the Great Arteries After Atrial Repair Operations (Mustard/Senning): A Review

“…Work performance evaluated by VO 2max was found to be significantly impaired, averaging 31.2 (16.0-43.2) ml/min/kg in nine reports [5,7,9,11,13,23,33,37,47] and representing a mean of 75.6% (50-89%) of the individual study normal control values. One study [5] suggested modestly improved performance after exercise training in five Mustard subjects.…”

“…Work performance as evaluated from determination of VO 2 at the ventricular anaerobic threshold during submaximal exercise was found to be significantly impaired in 18 Mustard children [4] and was further reported as 80% of normal for age in 12 Mustard patients [41], 79% of normal in 15 Senning patients [42], and 50% of normal in 14 adult Mustard patients (mean age 22 ± 3 years) [47]. Additionally, the oxygen uptake transient kinetics at the beginning of a constant-load exercise, characterized as the half-time (t 1 /2 ) or the time needed until half of the target VO 2 (80-90% of VO 2max ), was measured to be abnormally prolonged compared to controls [11]. Consequently, these subjects, in addition to being less qualified for endurance performance (VO 2max ), are disadvantaged for short-lasting, high-intensity exercise.…”

Velocity of Oxygen Uptake Response at the Onset of Exercise: A Comparison Between Children After Cardiac Surgery and Healthy Boys

“…O 2 response together with the maximal blood lactate and the maximal oxygen uptake of 35 children (23 boys and 12 girls) [6] with different heart malformations after cardiac surgery with the values of 10 healthy boys 10-12 years of age [5]. The mean age of the operated children was 10.8 ± 2.2 years.…”

“…O 2 response from mean values of oxygen uptake evaluated during half-minute periods ( Fig. 1 [5,6]. All measurements were taken with the boys running on a treadmill.…”

Exercise Testing After the Fontan Operation

“…However, in a study by Reybrouck et al [13], the ventilatory anaerobic threshold measured in 12 patients postoperatively on two occasions (an average of 1.9 years apart) decreased from 68% to 62% of normal, suggesting a decline in aerobic capac- Pediatric Cardiology ity with increasing time postoperatively. Oxygen uptake kinetics were studied in 5 patients after Fontan operation and compared to that of patients after repair of ventricular septal defect, tetralogy of Fallot, and transposition of the great arteries [8]. The half-time of oxygen uptake response was highest in patients after Fontan operation.…”