Oxygen-tuned nanozyme polymerization for the preparation of hydrogels with printable and antibacterial properties

Ye, Yuemei; Xiao, Linlin; He, Bin; Zhang, Qi; Nie, Tao; Yang, Xinrui; Wu, Dong; Cheng, Hongye; Li, Ping; Wang, Qigang

doi:10.1039/c6tb03317b

Cited by 37 publications

(25 citation statements)

References 52 publications

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“…Various nanozyme based applications have been extensively explored, including in vitro and in vivo biosensors, and antibacterial and disease therapies, such as cancer theranostics, bone marrow therapy, and wound healing . In addition, environmental protection is also an important area.…”

Section: Applications Of Nanozymesmentioning

confidence: 99%

Recent Advances in Nanozyme Research

2018

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inflammatory response to combat infections and can also react with many important biomolecules including proteins, lipids, and nucleic acid polymers (RNA and DNA). [7] Low dosage of ROS plays important roles in signal transduction, cell proliferation/migration/differentiation, and body defense against pathogen invasion. However, abnormally elevated ROS level can destroy redox homeostasis and cause oxidative stress and serious damage of structure and function of macromolecules in the cell. Research during the last decade has shown that oxidative stress could lead to diseases such as chronic inflammation and eventually diabetes, cancer, as well as cardiovascular, neurological, and pulmonary diseases. [8] Enzyme systems (e.g., superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase) are responsible for protecting cells from the detrimental effects of ROS by modulating the intracellular ROS level.Nanozyme can also modulate the ROS level in cells (Figure 2). [9] The ROS scavenging abilities of nanozymes largely originate from the SOD mimicking activities, which convert superoxide into H 2 O 2 and subsequently to O 2 and H 2 O, and thus reduce the intracellular ROS level and enhance cell viability. The generation of ROS originates from their peroxidases (POD) activities, which convert H 2 O 2 to OH· radicals, and oxidase activities, which convert O 2 to H 2 O 2 . Outside the cell, ROS can react with biologically active molecules (such as glucose, dopamine, glutathione, and adenosine triphosphate), organic compound (such as phenol and dyes), and pollutants from aqueous solutions. Thus the nanozymes could play important roles in in vitro test and environmental protection. [10] Earlier reports on nanozymes mainly focused on the aspect of experimental study and rarely focused on the theoretical work and mechanism clarification. In this progress report, we first introduce various nanozymes and highlight recent experimental development of new nanozymes that have been investigated to mimic various enzymes. Then we review their applications in various fields including biosensing, bioimaging, therapeutics, and environmental protection. At last, we summarize the catalytic mechanisms and address the challenges of experimental and computational research in this field. The Structure of NanozymesIssues of material design for high catalytical activity, selectivity, and durability are recently accentuated. Among them As a new generation of artificial enzymes, nanozymes have the advantages of high catalytic activity, good stability, low cost, and other unique properties of nanomaterials. Due to their wide range of potential applications, they have become an emerging field bridging nanotechnology and biology, attracting researchers in various fields to design and synthesize highly catalytically active nanozymes. However, the thorough understanding of experimental phenomena and the mechanisms beneath practical applications of nanozymes limits their rapid development. Herein, the progress of experimental and computational...

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Section: Applications Of Nanozymesmentioning

confidence: 99%

Recent Advances in Nanozyme Research

2018

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“…In a study, researchers prepared poly(DMAA‐cross‐BIS) hydrogel using peroxidase‐mimic CuO NPs. [ 218 ] Along with the direct gelation initiated by CuO nanozymes, it has been shown that fluorescent polydopamine can be synthesized via Fe 3 O 4 catalysis. [ 219 ] With improved physicochemical properties, nanozymes are expected to draw in expertise from diverse disciplines in the future and emerge as a new field of research in nanobiotechnology.…”

Section: Nanozymesmentioning

confidence: 99%

Micro‐Bio‐Chemo‐Mechanical‐Systems: Micromotors, Microfluidics, and Nanozymes for Biomedical Applications

et al. 2021

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Wireless nano‐/micromotors powered by chemical reactions and/or external fields generate motive forces, perform tasks, and significantly extend short‐range dynamic responses of passive biomedical microcarriers. However, before micromotors can be translated into clinical use, several major problems, including the biocompatibility of materials, the toxicity of chemical fuels, and deep tissue imaging methods, must be solved. Nanomaterials with enzyme‐like characteristics (e.g., catalase, oxidase, peroxidase, superoxide dismutase), that is, nanozymes, can significantly expand the scope of micromotors’ chemical fuels. A convergence of nanozymes, micromotors, and microfluidics can lead to a paradigm shift in the fabrication of multifunctional micromotors in reasonable quantities, encapsulation of desired subsystems, and engineering of FDA‐approved core–shell structures with tuneable biological, physical, chemical, and mechanical properties. Microfluidic methods are used to prepare stable bubbles/microbubbles and capsules integrating ultrasound, optoacoustic, fluorescent, and magnetic resonance imaging modalities. The aim here is to discuss an interdisciplinary approach of three independent emerging topics: micromotors, nanozymes, and microfluidics to creatively: 1) embrace new ideas, 2) think across boundaries, and 3) solve problems whose solutions are beyond the scope of a single discipline toward the development of micro‐bio‐chemo‐mechanical‐systems for diverse bioapplications.

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“…Interestingly, the catalytic activity of CuO NRs showed significant catalytic enhancement under visible light irradiation, allowing light control of antibacterial activity. 138,139 Nanoceria has a variety of enzymic properties. A nanoceria was discovered with both CAT and SOD properties, which was controlled by the Ce 3+ /Ce 4+ ratio.…”

Section: Nanozymes As Antimicrobial and Antifouling Agentsmentioning

confidence: 99%