Oxygen transport patterns in patients with sepsis syndrome or septic shock

Hayes, Michelle; Timmins, Andrew C.; Yau, E.H.S.; Palazzo, M. G. A.; Watson, David; Hinds, C. J.

doi:10.1097/00003246-199706000-00007

Cited by 152 publications

(64 citation statements)

References 46 publications

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“…In this regard, elevated levels of skeletal muscle PO 2 have been found in patients with severe sepsis (64,65). Moreover, non-survivors of sepsis exhibit impaired capacity to increase tissue oxygen consumption in response to a rise in oxygen delivery (66).…”

Section: Platelet Levels Of Cytochrome C Oxidase or Mitochondrial Resmentioning

confidence: 99%

New Prognostic Biomarkers of Mitochondrial Oxidative Stress in Septic Patients

Lorente¹

2015

Arch Crit Care Med

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Context: Sepsis is a common, expensive, and frequently fatal condition that is associated with as many deaths annually as is acute myocardial infarction. Evidence Acquisition: Sepsis could alter different pathways and cause inflammation, coagulation, apoptosis, and mitochondrial oxidative stress and dysfunction. This review focuses on new prognostic biomarkers of mortality due to mitochondrial oxidative stress in septic patients. Results: Recently some biomarkers of mitochondrial oxidative stress have been associated with prognosis in septic patients; they include circulating levels of malondialdehyde, total antioxidant capacity, melatonin level, platelet level of cytochrome c oxidase (COX) or mitochondrial respiratory complex IV, and mitochondrial deoxyribonucleic acid (mtDNA) haplogroup. Conclusions: Some biomarkers of mitochondrial oxidative stress (e.g. circulating levels of malondialdehyde, total antioxidant capacity, melatonin level, platelet level of COX, mtDNA haplogroup) have been recently associated with mortality in septic patients. These biomarkers could assist in the prognostic classification of septic patients and open new research lines in their treatment.

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Section: Platelet Levels Of Cytochrome C Oxidase or Mitochondrial Resmentioning

confidence: 99%

New Prognostic Biomarkers of Mitochondrial Oxidative Stress in Septic Patients

Lorente¹

2015

Arch Crit Care Med

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“…The CO increase in critical care patients is a questionable end-point [21][22][23] . As a rule, patients are in a hyperdynamic state (particularly patients not in overt heart failure, the vast majority of patients in a medical or surgical ICU), which is mainly characterized by high CO and the further increase of this particular parameter may be defined by what Heyland stated years ago as, "whipping a tired horse" [24, p.521] .…”

Section: Monitoring Devicesmentioning

confidence: 99%

Diagnostic tools and therapeutic end-points in critical care medicine: Limitations and concepts

Severino

Marum²,

Marcelino

2014

JNEP

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In Intensive Care Medicine (ICM) the presence of multiple high tech devices is common in order to perform multiple medical and non-medical procedures. The authors intend to perform a critical appraisal on the basic and practical/clinical approach to monitoring devices, analyzing the evidence support regarding clinical effects, end-points, and patient safety. All data that provides a diagnosis or a characterization of the patient's status will be considered diagnostic information whereas, variables that could be achieved by medical interventions will be considered therapeutic end-points. In any healthcare setting a careful approach to the patient is needed, namely in ICM one must consider the patient's clinical condition and choose adequate diagnostic tools and devices. Not all variables and devices currently on the market are suitable for each patient, nor proved useful in the setting under study. Also, all patients are different and must be approached differently according to established clinical end-points, translating into more holistic caregiving. ICM requires a personalized approach towards the patient, consequently, submitting diagnostic tools and monitoring devices to greater scrutiny in order to obtain greater patient benefit.

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“…In adults the ability to increase oxygen consumption as oxygen delivery is enhanced by clinical interventions is associated with better survival in septic shock. (16) No evidence in pediatrics exists that oxygen extraction decreases in septic shock. In children with septic or cardiogenic shock, the major determinant for oxygen consumption is oxygen delivery, not oxygen extraction (15); therefore, efforts should be aimed at improving CO and oxygen delivery.…”

Section: Septic Shockmentioning

confidence: 99%

Pediatric Shock

2008

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Oxygen transport patterns in patients with sepsis syndrome or septic shock

Cited by 152 publications

References 46 publications

New Prognostic Biomarkers of Mitochondrial Oxidative Stress in Septic Patients

New Prognostic Biomarkers of Mitochondrial Oxidative Stress in Septic Patients

Diagnostic tools and therapeutic end-points in critical care medicine: Limitations and concepts

Pediatric Shock

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