Oxygen transport and delivery in rabbits treated with cyanate

Aono, Makoto; Harkness, Donald R.; Flores, Alvaro; Gollan, Frank

doi:10.1016/s0024-3205(74)80005-6

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…Melaragno et al (22) have reported low oxygen tension in skin bubbles and venous blood in rats treated with cyanate. However, we were unable to demonstrate any differences in oxygen delivery, consumption or utilization between controls and rabbits treated with cyanate with doses sufficient to decrease whole blood Pso by 14Torr (2). In the present study there is no evidence of tissue hypoxia since arterial lactate and lactate-pyruvate ratios did not increase, even in the animals receiving the highest doses of cyanate.…”

Section: Discussioncontrasting

confidence: 82%

Effects of High-Dose Cyanate upon Cerebral Energy Metabolism of the Rat

Kogure¹,

Busto²,

Cassel³

et al. 1975

Pharmacology

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The effect of sodium cyanate (25, 50, 75, and 100 mg/kg body weight i.p. daily for 10 days) upon cerebral metabolism and the EEG of Wistar rats was studied. This treatment resulted in a dose-related carbamylation of hemoglobin and left shift in the oxygen dissociation curve. Animals receiving the highest dose of cyanate developed a significant systemic metabolic acidosis. In brain there was dose-dependent decrease in phospho-creatine, TCO₂ and cytoplasmic NADH/NAD⁺ ratio, reflecting the calculated drop in intra-cellular pH. Glucose levels were elevated despite a normal calculated energy charge, which suggests a balanced slowing of the energy-producing and energy-utilizing systems. The higher doses of cyanate produced spontaneous seizure activity on the EEG.

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Section: Discussioncontrasting

confidence: 82%