Oxygen—to little, too much or just right

Persson, Pontus B.; Persson, Anja Bondke

doi:10.1111/apha.13076

Cited by 1 publication

(1 citation statement)

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“…Oxygen is a significant microenvironmental factor that acts as a terminal electron acceptor in oxidative phosphorylation reactions to produce adenosine triphosphate (ATP). Hypoxia is an insufficient supply of oxygen to tissues, which results in abnormal cell metabolism and function [22,23]. According to the etiology of hypoxia, hypoxia can be classified as hypoxemic hypoxia, anemic hypoxia, stagnant hypoxia, or histotoxic hypoxia.…”

Section: The Change In Renin Under Hypoxiamentioning

confidence: 99%

Kidney Renin Release under Hypoxia and Its Potential Link with Nitric Oxide: A Narrative Review

Kong,

Liao,

Zhao

et al. 2023

Biomedicines

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The renin–angiotensin system (RAS) and hypoxia have a complex interaction: RAS is activated under hypoxia and activated RAS aggravates hypoxia in reverse. Renin is an aspartyl protease that catalyzes the first step of RAS and tightly regulates RAS activation. Here, we outline kidney renin expression and release under hypoxia and discuss the putative mechanisms involved. It is important that renin generally increases in response to acute hypoxemic hypoxia and intermittent hypoxemic hypoxia, but not under chronic hypoxemic hypoxia. The increase in renin activity can also be observed in anemic hypoxia and carbon monoxide-induced histotoxic hypoxia. The increased renin is contributed to by juxtaglomerular cells and the recruitment of renin lineage cells. Potential mechanisms regulating hypoxic renin expression involve hypoxia-inducible factor signaling, natriuretic peptides, nitric oxide, and Notch signaling-induced renin transcription.

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Section: The Change In Renin Under Hypoxiamentioning

confidence: 99%