Oxygen therapy for medical patients

Horner, Daniel; O’Driscoll, Ronan

doi:10.1136/bmj.k4436

Cited by 5 publications

(3 citation statements)

References 16 publications

(18 reference statements)

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“…Nonetheless, hypoxia mostly induce a pathological stress for cells that is closely related with the appearance and progress of a broad spectrum of diseases [19]. As a result, oxygen has been proposed as a potential therapeutic agent for patients undergoing different acute or chronic conditions [20,21]. As targeting cellular hypoxia is a promising, but still an emerging approach [22], clinical management of hypoxia is directed to modulate global hypoxemia and oxygen delivery within the tissues [23].…”

Section: Physiological Role Of Oxygen In the Organismmentioning

confidence: 99%

A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities

et al. 2021

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Hyperbaric oxygen therapy (HBOT) consists of using of pure oxygen at increased pressure (in general, 2–3 atmospheres) leading to augmented oxygen levels in the blood (Hyperoxemia) and tissue (Hyperoxia). The increased pressure and oxygen bioavailability might be related to a plethora of applications, particularly in hypoxic regions, also exerting antimicrobial, immunomodulatory and angiogenic properties, among others. In this review, we will discuss in detail the physiological relevance of oxygen and the therapeutical basis of HBOT, collecting current indications and underlying mechanisms. Furthermore, potential areas of research will also be examined, including inflammatory and systemic maladies, COVID-19 and cancer. Finally, the adverse effects and contraindications associated with this therapy and future directions of research will be considered. Overall, we encourage further research in this field to extend the possible uses of this procedure. The inclusion of HBOT in future clinical research could be an additional support in the clinical management of multiple pathologies.

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Section: Physiological Role Of Oxygen In the Organismmentioning

confidence: 99%

A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities

et al. 2021

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“…Oxygen therapy refers to a medical procedure that relieves hypoxia by increasing the PaO 2 in the inhaled gas and SaO 2 in the blood. 10 It is widely used for central nervous system (CNS) disease therapy. Standard oxygen therapy includes hyperbaric oxygen (HBO) and normobaric oxygen (NBO) therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, oxygen therapy may delay or mitigate the progression of stroke. Oxygen therapy refers to a medical procedure that relieves hypoxia by increasing the PaO 2 in the inhaled gas and SaO 2 in the blood 10 . It is widely used for central nervous system (CNS) disease therapy.…”

Section: Introductionmentioning

confidence: 99%

The neuroprotective effects of normobaric oxygen therapy after stroke

Li,

Jiang,

Chen

et al. 2024

CNS Neurosci Ther

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BackgroundStroke, including ischemic and hemorrhagic stroke, is a severe and prevalent acute cerebrovascular disease. The development of hypoxia following stroke can trigger a cascade of pathological events, including mitochondrial dysfunction, energy deficiency, oxidative stress, neuroinflammation, and excitotoxicity, all of which are often associated with unfavorable prognosis. Nonetheless, a noninvasive intervention, referred to as normobaric hyperoxia (NBO), is known to have neuroprotective effects against stroke.ResultsNBO can exert neuroprotective effects through various mechanisms, such as the rescue of hypoxic tissues, preservation of the blood–brain barrier, reduction of brain edema, alleviation of neuroinflammation, improvement of mitochondrial function, mitigation of oxidative stress, reduction of excitotoxicity, and inhibition of apoptosis. These mechanisms may help improve the prognosis of stroke patients.ConclusionsThis review summarizes the mechanism by which hypoxia causes brain injury and how NBO can act as a neuroprotective therapy to treat stroke. We conclude that NBO has significant potential for treating stroke and may represent a novel therapeutic strategy.

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