Oxygen therapy for corneal edema after cataract surgery

Sharifipour, Farideh; Panahi-Bazaz, Mahmoodreza; Idani, Esmaeil; Hajizadeh, Maryam; Saki, Azadeh

doi:10.1016/j.jcrs.2014.10.033

Cited by 14 publications

(21 citation statements)

References 8 publications

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“…In 2015, Sharifipour et al reported that supplement trans‐corneal normo‐baric oxygen therapy at a flow rate of 5 L/min for 1 hr twice daily after cataract surgery decreased corneal oedema more rapidly than medical therapy and systemic oxygen therapies and preserved more endothelial cells. The authors suggest that trans‐corneal oxygen mitigates the damage to endothelial cells before permanent loss occurs, thus improving endothelial pump function and decreasing corneal oedema.…”

Section: Discussionmentioning

confidence: 99%

“…A decrease in pump function can lead to corneal oedema and to a reduced ability to clear existing excess fluids (Waring et al 1982). A recent study showed that supplemental trans‐corneal oxygen therapy after cataract surgery led to a more rapid resolution of corneal oedema when compared to medical therapy (topical steroids and sodium chloride 5% eye drops) and systemic oxygen therapy, and preserved more endothelial cells (Sharifipour et al 2015). The authors suggested that trans‐corneal oxygen mitigates the damage to the endothelial cells before permanent loss occurs, thus improving overall pump function and decreasing corneal oedema.…”

Section: Introductionmentioning

confidence: 99%

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Eye patching after cataract surgery is associated with an increased risk of short‐term corneal oedema

Gazit

Dubinsky‐Pertzov

et al. 2020

Acta Ophthalmologica

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Purpose To evaluate the effect of postoperative eye patching after routine cataract surgery on corneal oedema and visual acuity on the first postoperative day. Setting One public healthcare centre. Design and methods This randomized controlled trial included patients undergoing uneventful cataract surgery in one medical centre. Patients were randomized into two groups: the surgical eye was patched with a single dose of a local steroid and antibiotic for 24 hr in the first group, and a plastic shield was used in the second with local steroid and antibiotic drops. The eyes were examined preoperatively and on the first postoperative day. Examination included the following: best‐corrected visual acuity (BCVA), full slit lamp examination, intraocular pressure (IOP), anterior chamber depth (ACD) and central corneal thickness (CCT) using the IOL Master 700 (Zeiss, Germany). Cumulative dissipated energy (CDE) and operation time were recorded for all cases. Results One hundred eyes of 100 patients were included in the study. The postoperative increase in CCT 24 hr after surgery was 138 and 70 µm in the patched group as compared to the non‐patched group, respectively (p = 0.001). Best‐corrected visual acuity (BCVA) on the first postoperative day was 0.5 ± 0.45 LogMAR and 0.3 ± 0.3 LogMAR in the patched and non‐patched group, respectively (p = 0.01). There was no difference in CDE (11.33 ± 9.2 and 10.22 ± 7.3; p = 0.94) between the two groups. Conclusions Eye patching after routine cataract surgery is associated with an increase in corneal oedema and slower visual recovery on the first postoperative day.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eye patching after cataract surgery is associated with an increased risk of short‐term corneal oedema

Gazit

Dubinsky‐Pertzov

et al. 2020

Acta Ophthalmologica

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“…Although many cases with positive results have been published, clear evidence of its positive effect is scarce 18 - 20 . Another rarely used alternative is systemic or local oxygen therapy as proposed by Sharifipour, et al 15 , 16 . In our case, we obtained good results by adding to the medical management both the use of the amniotic membrane and oxygen therapy using masks or cameras over the eye.…”

Section: Discussionmentioning

confidence: 99%

“…One week after the burn, one-hour daily 100% oxygen therapy via a face mask at 10 L/min was started (16 sessions). Besides, six sessions of 5 L/min of oxygen application were performed on the right eye with a camera made for that purpose 15 , 16 . Twenty days after the burn, the amniotic membrane had been almost completely reabsorbed, with only a remnant observed on the temporal conjunctiva, and 95% of the cornea was epithelialized with only two remaining areas with fluorescein staining ( figure 4 ).…”

Section: Clinical Casementioning

confidence: 99%

Severe corneal burn due to the accidental application of salicylic acid packed in a plastic dropper bottle

et al. 2020

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Eye burns due to the accidental application of pharmacological or nonpharmacological substances packaged in plastic dropper bottles have been described for more than three decades and continue to occur. These burns can cause potentially serious corneal injuries. We report the case of a patient who mistakenly applied salicylic acid to the right eye after confusing it with an eye lubricant, which caused him a severe corneal burn. Fortunately, after aggressive medical and surgical management (including oxygen therapy and amniotic membrane grafting), the visual results were good.We suggest conducting educational campaigns and taking legislative measures in our country to avoid packaging corrosive substances in this type of dropper bottle to reduce the risk of accidental burns.

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“…Nevertheless, from the perspective of clinical practice, there are inevitably some postoperative complications after surgery [16]. Corneal edema is a common postoperative complication [17], and studies showed that postoperative adjustment by combining traditional Chinese medicine can improve the effect of cataract treatment [18]. Some plateau herbs have been found to be effective in treating cataract.…”

Section: Introductionmentioning

confidence: 99%

Uncovering The Mechanism of Shiwuwei Luodimingmu Wan On Cataract Via Network Pharmacology

Zhang

Wang

et al. 2021

Preprint

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Cataract is one of the most common eye diseases. The purpose of this study was to screen the active components and potential targets of Shiwuwei Luodimingmu Wan, then to explore the mechanism of Shiwuwei Luodimingmu Wan in the treatment of cataract through network pharmacology. Information about the chemical constituents and their targets of herbs in Shiwuwei Luodimingmu Wan was collected from traditional Chinese medicine system pharmacology (TCMSP) database. Cataract related genes were searched in Pubmed-Gene database and Genecards database. Then, the possible protein-protein interactions (PPIs) were derived from STRING database. Next, compound-target-diseases network was constructed using Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using DAVID. Furthermore, we evaluated binding potential of key targets and compounds through molecular docking. There were 102 active components including quercetin, baicalein and kaempferol in Shiwuwei Luodimingmu Wan and 28 potential targets related to cataract. More importantly, these genes are involved in several pathways associated with cataract. Docking results showed that core compound (quercetin) had certain affinity with MAPK14. This study revealed that the ability of Shiwuwei Luodimingmu Wan to produce clarity of vision may was achieved through quercetin to affect multiple targets and pathways.

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Oxygen therapy for corneal edema after cataract surgery

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 14 publications

References 8 publications

Eye patching after cataract surgery is associated with an increased risk of short‐term corneal oedema

Eye patching after cataract surgery is associated with an increased risk of short‐term corneal oedema

Severe corneal burn due to the accidental application of salicylic acid packed in a plastic dropper bottle

Uncovering The Mechanism of Shiwuwei Luodimingmu Wan On Cataract Via Network Pharmacology

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