Oxygen tension in human tumors: in vivo mapping using CT-guided probes.

Abstract

The role of oxygen in tumor response to therapy has been studied for several decades. We describe a technique that allows in vivo measurement of oxygen in tumors using computed tomography to guide probes. In the evaluation of 16 tumors, oxygen tensions were found to be substantially lower than surrounding tissue and varied nonrandomly. This technique has allowed construction of detailed tumor oxygen level maps.

In vivo oxygen tension and temperature: Simultaneous determination using 19F NMR spectroscopy of perfluorocarbon

“…The simultaneous equations may also be solved graphically as shown in Figs. 5 and 6. Each resonance provides an R, isocontour with a set of solutitons, however, taken in combination the intersection of two lines uniquely defines both PO, and temperature.…”

“…Many techniques exist to measure these parameters in tissue, but these are generally invasive and sample small highly localized volumes only, e.g., oxygen microelectrodes (5), mass spectrometer probes (6), biopsy and cryospectrophotometry (7), and thermocouples (8). Other techniques are limited to surface tissue studies, e.g., fluorescence (9) and surface electrodes (10).…”

Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells

“…It is well documented that the micromilieu of a solid tumour contains areas of low oxygen tension (Thomlinson & Gray, 1955;Tannock, 1972;Gray et al, 1953;Hill & Bush, 1977;Gatenby et al, 1985) cells to acidosis which also resulted in a relatively large proportion of KHT cells (14-18%) with overreplicated DNA did lead to a small increase in MTX resistance. The extent of this resistance was not, however, obviously correlated with the proportion of cells with excess DNA content.…”

Polarographischer Nachweis einer Reoxygenierung von Lymphknotenmetastasen in der Initialphase einer primären Radio- und Radiochemotherapie bei Patienten mit fortgeschrittenen Plattenepithel- karzinomen im Kopf-Hals-Bereich

“…Tumoren des KopfHals-Bereichs sind für dieses Verfahren wegen ihrer oftmals oberflächlichen Lage und der dadurch leichten Zugäng-lichkeit besonders geeignet. Verschiedene Untersucher konnten bereits nachweisen, daß Plattenepithelkarzinome des Kopf-Hals-Bereichs und deren zervikale Lymphknotenmetastasen eine schlechte Oxygenierung aufweisen [3,8,10,17,23].…”