Oxygen-supplementing mesoporous polydopamine nanosponges with WS2 QDs-embedded for CT/MSOT/MR imaging and thermoradiotherapy of hypoxic cancer

Wang, Yidan; Song, Shaoze; Lü, Tong; Cheng, Yating; Song, Yilin; Wang, Siyu; Tan, Fengping; Li, Jiao; Li, Nan

doi:10.1016/j.biomaterials.2019.119405

Cited by 105 publications

(64 citation statements)

References 51 publications

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“…Therefore, RT and PTT can obviate the limitation of the other and produce a synergistic anti-tumor effect if used in combination ( Table 4). [108][109][110][111][112][113][114][115][116] The challenge, however, is to integrate photothermal sensitizers and radiosensitizers in a biocompatible nano-platform. Reproduced with permission.…”

Section: Combination Of Ptt and Rtmentioning

confidence: 99%

Transition Metal Dichalcogenides for Sensing and Oncotherapy: Status, Challenges, and Perspective

Wang

Lan

et al. 2020

Adv Funct Materials

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Transition metal dichalcogenides (TMDCs) are increasingly being used for chemical sensing, biosensing, and tumor therapy on account of their diversity, biocompatibility, multifunctionality, adjustable bandgap, and excellent photoelectric characteristics. This review mainly discusses the effect of the elemental composition and structure of TMDCs on the performance of electrochemical, biofluorescence, and colorimetric biosensors. The applications of TMDCs in tumor therapies are reviewed here. Furthermore, the current challenges and future directions for developing TMDC‐based theranostics are summarized.

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Section: Combination Of Ptt and Rtmentioning

confidence: 99%

Transition Metal Dichalcogenides for Sensing and Oncotherapy: Status, Challenges, and Perspective

Wang

Lan

et al. 2020

Adv Funct Materials

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“…Finally, they attached manganese dioxide (MnO 2 ) ( Figure 7 a). [ 80 ] In order to verify the heating effect of the nanoparticles in vivo, 4T1 tumor‐bearing mice were injected with nanoparticles and irradiated with 808 nm NIR laser light (1.5 W cm −2 ) after 12 h over the tumor region for 5 min. They found that mice treated with MPDA–WS 2 @MnO 2 NPs generated thermal energy within the tumor tissue, with temperatures up to 54 °C in 4 min, adequate for killing cancer cells (Figure 7b).…”

Section: Polydopamine‐based Multifunctional Platforms For Synergisticmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mussel‐Inspired Polydopamine: The Bridge for Targeting Drug Delivery System and Synergistic Cancer Treatment

Wang

Tang

Zhang

et al. 2020

Macromolecular Bioscience

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PDA has been applied in the biomedical field that for drug delivery, bioimaging, and tissue engineering biosensing applications. [10-12] Because of its specific structure, PDA is capable of loading antitumor drugs (such as doxorubicin (DOX)) via π-π stacking or hydrogen bonding interactions, with loading rates as high as 91%. Surprisingly, in addition to its strong ability to adsorb drugs, PDA is effective in releasing drugs by internal stimulation (hydrogen peroxide) or from an external stimulus (nearinfrared (NIR) irradiation), reducing the toxic effects of chemotherapeutic drugs. [13-15] Moreover, by exhibiting 40% light-to-heat conversion efficiency, PDA can act as a photothermal agent, able to produce sufficient heat to ablate cancer cells when irradiated with 808 nm NIR light. Compared with other photothermal materials, including carbon or copper-based nanomaterials and gold nanoparticles, the photothermal conversion effect of PDA is greater with better biocompatibility. [16-20] It has been reported that monotherapy has multiple limitations due to its heterogeneity and the drug resistance of tumors, with synergistic therapies that are more effective for cancer treatment. [21] Because of the large number of catechol and amine groups, PDA displays superior adhesion, endowing PDA films with the ability to adhere to a variety of material surfaces, such as gold nanoparticles, iron oxide, silica, and polylactic-co-glycolic acid (PLGA). Thus, PDA has been utilized to functionalize almost every form of nanomaterial by dopamine polymerization. More importantly, a layer of PDA provides nanomaterials with highly desirable properties, including the ability to be loaded with drugs allowing their controlled-release, excellent photothermal conversion efficiency and biocompatibility, and so facilitating the creation of multifunctional drug delivery systems for combined treatment by combining photothermal therapy (PTT) or chemotherapy with other therapies. [22-25] Additionally, the catechol and amino groups on PDA provide a bridge for subsequent modification. For example, PDA can act as a link to introduce tumor-targeting ligands using its amine and thiol groups via a Michael addition or Schiff reaction, allowing nanoparticles to become enriched at the tumor site. [26-28] Using these properties of PDA, researchers have developed diverse forms of PDA-based multifunctional platforms for synergistic cancer therapies. Wang et al. [29] reviewed Polydopamine (PDA), a mussel-inspired molecule, has been recognized as attractive in cancer therapy due to a number of inherent advantages, such as good biocompatibility, outstanding drug-loading capacity, degradability, superior photothermal conversion efficiency, and low tissue toxicity. Furthermore, due to its strong adhesive property, PDA is able to functionalize various nanomaterials, facilitating the construction of a PDA-based multifunctional platform for targeted or synergistic therapy. Herein, recent PDA research, including targeted drug delivery, single-mode therapy, and diverse...

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“…Pd and Pt possess high photothermal stability due to the high melting point compared with Au (Li et al, 2020). To improve the PCE of noble metals in NIR‐II biowindow, Wang et al (2019) developed spirals superstructure Pt biomaterials with outstanding PCE (52.5%) for photo hyperthermia (Figure 5b).…”

Section: Energy‐converting Biomaterials For Cancer Therapymentioning

confidence: 99%

Energy‐converting biomaterials for cancer therapy: Category, efficiency, and biosafety

Dong

Sun

et al. 2020

WIREs Nanomed Nanobiotechnol

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Energy‐converting biomaterials (ECBs)‐mediated cancer‐therapeutic modalities have been extensively explored, which have achieved remarkable benefits to overwhelm the obstacles of traditional cancer‐treatment modalities. Energy‐driven cancer‐therapeutic modalities feature their distinctive merits, including noninvasiveness, low mammalian toxicity, adequate therapeutic outcome, and optimistical synergistic therapeutics. In this advanced review, the prevailing mainstream ECBs can be divided into two sections: Reactive oxygen species (ROS)‐associated energy‐converting biomaterials (ROS‐ECBs) and hyperthermia‐related energy‐converting biomaterials (H‐ECBs). On the one hand, ROS‐ECBs can transfer exogenous or endogenous energy (such as light, radiation, ultrasound, or chemical) to generate and release highly toxic ROS for inducing tumor cell apoptosis/necrosis, including photo‐driven ROS‐ECBs for photodynamic therapy, radiation‐driven ROS‐ECBs for radiotherapy, ultrasound‐driven ROS‐ECBs for sonodynamic therapy, and chemical‐driven ROS‐ECBs for chemodynamic therapy. On the other hand, H‐ECBs could translate the external energy (such as light and magnetic) into heat for killing tumor cells, including photo‐converted H‐ECBs for photothermal therapy and magnetic‐converted H‐ECBs for magnetic hyperthermia therapy. Additionally, the biosafety issues of ECBs are expounded preliminarily, guaranteeing the ever‐stringent requirements of clinical translation. Finally, we discussed the prospects and facing challenges for constructing the new‐generation ECBs for establishing intriguing energy‐driven cancer‐therapeutic modalities. This article is categorized under: Nanotechnology Approaches to Biology >Nanoscale Systems in Biology

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Oxygen-supplementing mesoporous polydopamine nanosponges with WS2 QDs-embedded for CT/MSOT/MR imaging and thermoradiotherapy of hypoxic cancer

Cited by 105 publications

References 51 publications

Transition Metal Dichalcogenides for Sensing and Oncotherapy: Status, Challenges, and Perspective

Transition Metal Dichalcogenides for Sensing and Oncotherapy: Status, Challenges, and Perspective

Mussel‐Inspired Polydopamine: The Bridge for Targeting Drug Delivery System and Synergistic Cancer Treatment

Energy‐converting biomaterials for cancer therapy: Category, efficiency, and biosafety

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