Oxygen Sensor-Guided Fine Needle Biopsy Studies of Human Cancer Xenografts in Mice
Robert C. McDonald,
Andrew H. Fischer,
Mary Rusckowski
Abstract:An oxygen sensor-mounted fine-needle biopsy tool was used forin vivomeasurement of oxygen levels in tumor xenografts. The system provides a means of measuring the oxygen content in harvested tumor tissue from specific locations. Oxygen in human tumor xenografts in a murine model was observed for over 1 min. Tissues were mapped in relation to oxygen tension (pO2) readings and sampled for conventional cytological examination. Careful modeling of the pO2readings over 60 seconds yielded a diffusion coefficient for… Show more
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