Oxygen Sensing: Physiology and Pathophysiology

Aaronson, Philip I.; Rocher, A.

doi:10.3390/antiox11051018

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…H 2 S can regulate oxygen-sensing enzymes and transcription factors in vascular cells through multiple molecular mechanisms [28]. One of the primary mechanisms by which H 2 S regulates oxygen sensing is through the modulation of prolyl hydroxylase domain (PHD) enzymes, which play a critical role in regulating the activity of hypoxia-inducible factors (HIFs) [58]. HIF-1α activation can promote gene expression in cell survival, angiogenesis, and glycolysis, mitigating hyperoxia's effects [59].…”

Section: Oxygen Homeostasis In Atherosclerosis and The Role Of Hydrog...mentioning

confidence: 99%

Hydrogen Sulfide and Oxygen Homeostasis in Atherosclerosis: A Systematic Review from Molecular Biology to Therapeutic Perspectives

Munteanu

2023

IJMS

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Atherosclerosis is a complex pathological condition marked by the accumulation of lipids in the arterial wall, leading to the development of plaques that can eventually rupture and cause thrombotic events. In recent years, hydrogen sulfide (H2S) has emerged as a key mediator of cardiovascular homeostasis, with potential therapeutic applications in atherosclerosis. This systematic review highlights the importance of understanding the complex interplay between H2S, oxygen homeostasis, and atherosclerosis and suggests that targeting H2S signaling pathways may offer new avenues for treating and preventing this condition. Oxygen homeostasis is a critical aspect of cardiovascular health, and disruption of this balance can contribute to the development and progression of atherosclerosis. Recent studies have demonstrated that H2S plays an important role in maintaining oxygen homeostasis by regulating the function of oxygen-sensing enzymes and transcription factors in vascular cells. H2S has been shown to modulate endothelial nitric oxide synthase (eNOS) activity, which plays a key role in regulating vascular tone and oxygen delivery to tissues. The comprehensive analysis of the current understanding of H2S in atherosclerosis can pave the way for future research and the development of new therapeutic strategies for this debilitating condition. PROSPERO ID: 417150.

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Section: Oxygen Homeostasis In Atherosclerosis and The Role Of Hydrog...mentioning

confidence: 99%

Hydrogen Sulfide and Oxygen Homeostasis in Atherosclerosis: A Systematic Review from Molecular Biology to Therapeutic Perspectives

Munteanu

2023

IJMS

View full text Add to dashboard Cite

show abstract

Oxygen Sensing: Physiology and Pathophysiology

Abstract: Oxygen is such an essential element for life that multiple mechanisms have evolved to maintain oxygen homeostasis, including those which detect decreases in arterial O2 and generate adaptive responses to hypoxia [...]

Cited by 1 publication

References 23 publications

Hydrogen Sulfide and Oxygen Homeostasis in Atherosclerosis: A Systematic Review from Molecular Biology to Therapeutic Perspectives

Hydrogen Sulfide and Oxygen Homeostasis in Atherosclerosis: A Systematic Review from Molecular Biology to Therapeutic Perspectives

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