Oxygen Sensing in the Ductus Arteriosus: Endothelin Still a Player

Coceani, Flavio

doi:10.1161/circresaha.113.301615

Cited by 1 publication

(1 citation statement)

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“…With the decrease in pulmonary vascular resistance there is an increase in pulmonary blood flow, which culminates with ductal occlusion (Obladen, ; Hong et al, ). The functional closure of ductus arteriosus is initiated by a mechanism induced by the higher blood oxygen concentration (Coceani, ). This mechanism, albeit mediated by prostaglandins and endothelins, is intrinsic to smooth muscle cells (Michelakis et al, ).…”

Section: Fetal Ductus Arteriosus and Ductal Constrictionmentioning

confidence: 99%

Prenatal effects of maternal consumption of polyphenol‐rich foods in late pregnancy upon fetal ductus arteriosus

Zielinsky¹,

Busato²

2013

Birth Defects Research Pt C

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Fetal circulation has characteristic features, being morphologically and functionally different from extrauterine circulation. The ductus arteriosus plays a fundamental role in directing the blood flow to fetal inferior body parts. Basically, the ductus arteriosus directs 80–85% of the right ventricular output arising from the superior vena cava, coronary sinus, and a small part from the inferior vena cava to descending aorta. Its histological structure is made up predominantly by a thick muscular layer, differently from the aorta and the pulmonary artery, which increases with gestational age. The fibers have a circumferential orientation, especially at the external layers, facilitating and making effective ductal constriction. These factors may generate lumen alterations which may cause fetal and neonatal complications, such as heart failure, hydrops, neonatal pulmonary hypertension, and even death. Classically, maternal administration of indomethacin and/or other antiinflammatory drugs interfere in prostaglandins metabolism, causing ductal constriction. However, many cases of fetal ductal constriction, as well as of persistent neonatal pulmonary artery hypertension, remain without an established etiology, being referred as “idiopathic.” In recent years, a growing body of evidence has shown that herbs, fruits, nuts, and a wide diversity of substances commonly used in daily diets have definitive effects upon the metabolic pathway of inflammation, with consequent inhibition of prostaglandins synthesis. This antiinflammatory action, especially of polyphenols, when ingested during the third trimester of pregnancy, may influence the dynamics of fetal ductus arteriosus flow. The goal of this review is to present these new observations and findings, which may influence dietary orientation during pregnancy. Birth Defects Research (Part C) 99:256–274, 2013. © 2013 Wiley Periodicals, Inc.

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Section: Fetal Ductus Arteriosus and Ductal Constrictionmentioning

confidence: 99%