Oxygen saturation levels in the juxta-papillary retina in eyes with glaucoma

Ito, M.; Murayama, Keiji; Deguchi, Tatsuya; Takasu, M; Gil, Tamir; Araie, Makoto; Peyman, Gholam A.; Yoneya, Shin

doi:10.1016/j.exer.2007.12.010

Cited by 32 publications

(33 citation statements)

References 21 publications

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“…29 More recently, the Fourier transform spectral retinal imaging system was used to compare the OS of the retinal tissues and blood vessels around the optic disc in normal eyes, and eyes with open-angle glaucoma. 30 Overall, 15 eyes with low-tension glaucoma and 41 eyes with hightension glaucoma were compared with 20 normal eyes. The average OS of the juxtapapillary retinal tissues in eyes with normal-tension glaucoma (78 ± 8%) and high-tension glaucoma (82 ± 10%) were reported to be significantly lower than in normal eyes (88 ± 8%; P ¼ 0.002 and P ¼ 0.039, respectively).…”

Section: Principles Of Retinal Oximetrymentioning

confidence: 99%

Spectral imaging of the retina

Mordant

Alabboud

Muyo

et al. 2011

Eye

107

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Introduction The work described here involved the use of a modified fundus camera to obtain sequential hyperspectral images of the retina in 14 normal volunteers and in 1 illustrative patient with a retinal vascular occlusion. Methods The paper describes analysis techniques, which allow oximetry within retinal vessels; these results are presented as retinal oximetry maps. Results Using spectral images, with wavelengths between 556 and 650 nm, the mean oxygen saturation (OS) value in temporal retinal arterioles in normal volunteers was 104.3 ( ± 16.7), and in normal temporal retinal venules was 34.8 (±17.8). These values are comparable to those quoted in the literature, although, the venular saturations are slightly lower than those values found by other authors; explanations are offered for these differences. Discussion The described imaging and analysis techniques produce a clinically useful map of retinal oximetric values. The results from normal volunteers and from one illustrative patient are presented. Further developments, including the recent development of a 'snapshot' spectral camera, promises enhanced non-invasive retinal vessel oximetry mapping.

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Section: Principles Of Retinal Oximetrymentioning

confidence: 99%

Spectral imaging of the retina

Mordant

Alabboud

Muyo

et al. 2011

Eye

107

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show abstract

“…Studies using various retinal oximetry devices to measure the oxygen saturation of the retinal vasculature in glaucoma have been reported. [12][13][14][15][16][17][18][19][20] Hyperspectral imaging combines spectroscopy with digital imaging whereby spectral data (using numerous contiguous wavelengths of light) are obtained in every pixel of an image plane. An oximetry study of the retinal vascular network using a hyperspectral imaging system (images acquired using more than three contiguous wavelengths) in glaucoma has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Oxygen saturation measurements of the retinal vasculature in treated asymmetrical primary open-angle glaucoma using hyperspectral imaging

Mordant

Alabboud

Muyo

et al. 2014

Eye

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Purpose To determine whether there are differences in retinal vascular oxygen saturation measurements, estimated using a hyperspectral fundus camera, between normal eyes and treated eyes of subjects with asymmetrical primary open-angle glaucoma (POAG). Methods A noninvasive hyperspectral fundus camera was used to acquire spectral images of the retina at wavelengths between 556 and 650 nm in 2-nm increments. In total, 14 normal eyes and both eyes of 11 treated POAG subjects were imaged and analyzed using algorithms that use the spectral variation of the optical densities of blood vessels to estimate the oxygen saturation of blood within the retinal vasculature. In the treated POAG group, each of the eyes were categorized, based on the mean deviation of the Humphrey visual-field analyzer result, as either more-advanced or less-advanced, glaucomatous eyes. Unpaired t-tests (twotailed) with Welch's correction were used to compare the mean oxygen saturation between the normal subjects and the treated POAG subgroups. Results In less-advanced and moreadvanced-treated POAG eyes, mean retinal venular oxygen saturations (48.2 ± 21.6% and 42.6 ± 18.8%, respectively) were significantly higher than in normal eyes (27.9 ± 9.9%; P ¼ 0.03 and 0.01, respectively). Arteriolar oxygen saturation was not significantly different between normal eyes and treated POAG eyes. ConclusionsThe increased oxygen saturation of the retinal venules in advancedtreated POAG eyes may indicate reduced metabolic consumption of oxygen in the inner retinal tissues.

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“…Information on this instrument was described in detail previously. 9,10 The retinal cube system consists of an SD-200 optical head, which uses a Sagnac interferometer (ASI Co.) mounted on top of a fundus camera (TRC-50IA, Topcon Co., Tokyo, Japan) and software with acquisition and analysis modules. This system allows measurement of a spectrum in each pixel of the fundus image.…”

Section: Oxygen Saturation Measured By Spectral Retinal Imagingmentioning

confidence: 99%

“…Recently, technological developments have enabled us to measure oxygen saturation levels in the fundus with a 35°c amera. 9,10 This technology can be used to study oxygen levels in retinochoroidal vasculature in a wide variety of diseases and may allow us to investigate clinically the pathophysiologic features of the eye from a new perspective. The aim of this study was to investigate the functional effects of PDT on the retina-choroid, such as macular oxygen saturation and electrophysiological function, using Fourier transform-based spectral retinal imaging (SRI), Heidelberg retinal flowmeter (HRF), and multifocal electroretinogram (mfERG).…”

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confidence: 99%