Oxygen saturation in cystic fibrosis.

Betancourt, Marian; Slade, G; Dinwiddie, R

doi:10.1136/adc.66.9.1075

Cited by 9 publications

(1 citation statement)

References 4 publications

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“…We found that SpO 2 levels progressively diminished as pulmonary function (FEV 1 ) decreased, a finding that has been already described by other authors [ 37 , 38 ]. Therefore, in our study the higher levels of SpO 2 reached during glycine administration probably were reflecting the improvement of respiratory function.…”

Section: Discussionsupporting

confidence: 89%

Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial

et al. 2017

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BackgroundPatients with cystic fibrosis (CF) have airway inflammation that contributes to symptoms and to pulmonary function derangement. Current drugs used to diminish airway inflammation improve the clinical and spirometric status of patients with CF, but their use is limited due to their undesired side effects, for example, glucose intolerance, growth retardation, and cataracts with corticosteroids, gastrointestinal toxicity with ibuprofen, and macrolide resistance with azythromycin. Glycine is known to decrease activation of inflammatory cells, including alveolar macrophages and neutrophils, and is relatively inexpensive, palatable, and virtually devoid of untoward effects. These features make glycine a good candidate for antiinflammatory treatment of CF. Thus, we aimed to explore whether glycine can exert a beneficial effect in a population of patients with CF.MethodsThis was a randomized, double blinded, cross-over pilot clinical trial. Subjects with CF received, in random order, oral glycine (0.5 g/kg/day, dissolved in any liquid) and placebo (glass sugar), each during 8 weeks with an intermediate 2-week wash-out period.ResultsThirteen subjects aged 6–23 years, 8 females, completed the two arms of the study. As compared with placebo, after glycine intake patients had better symptom questionnaire scores (p = 0.02), mainly regarding sputum features and dyspnea. While spirometric variables tended to decline during placebo intake, they remained stable or even increased during glycine treatment (p = 0.04 to p = 0.003). In this context, FEV1 declined 8.6% after placebo and increased 9.7% at the end of the glycine period. Pulse oximetry improved after glycine intake (p = 0.04 vs. placebo). TNF-α in serum and IL-6 and G-CSF in sputum tended to decline at the end of the glycine period (p = 0.061, p = 0.068 and p = 0.04, respectively, vs placebo). Glycine was remarkably well tolerated.ConclusionsThe clinical, spirometric and inflammatory status of subjects with CF improved after just 8 weeks of glycine intake, suggesting that this amino acid might constitute a novel therapeutic tool for these patients. Thus, further studies are warranted.Trial registration www.clinicaltrials.gov, registration number: NCT01417481, date of registration: March 12, 2012.Electronic supplementary materialThe online version of this article (10.1186/s12890-017-0528-x) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 89%