Oxygen requirements of Strongyloides papillosus infective larvae

Costello, Leslie C.; S, Grollman

doi:10.1016/0014-4894(58)90028-6

Cited by 11 publications

(3 citation statements)

References 17 publications

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“…Although the study of metabolism in parasitic nematodes is hampered by the difficulty in obtaining sufficient numbers, it is known that during reproductive growth in their hosts certain species of parasitic larvae migrate through the circulatory system, lungs and trachea, where aerobic conditions are high [ 3 , 4 ]. Furthermore, iL3 larvae of the hookworm Ancylostoma caninum are suggested to use fat reserves as an energy source [ 23 ], and there is an inverse correlation between oxygen consumption and iL3 longevity in parasitic nematodes [ 24 ]. These findings suggest that similar mechanisms control developmental energy metabolism in free-living and parasitic nematodes.…”

Section: Introductionmentioning

confidence: 99%

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

et al. 2015

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Appropriate nutrient response is essential for growth and reproduction. Under favorable nutrient conditions, the C. elegans nuclear receptor DAF-12 is activated by dafachronic acids, hormones that commit larvae to reproductive growth. Here, we report that in addition to its well-studied role in controlling developmental gene expression, the DAF-12 endocrine system governs expression of a gene network that stimulates the aerobic catabolism of fatty acids. Thus, activation of the DAF-12 transcriptome coordinately mobilizes energy stores to permit reproductive growth. DAF-12 regulation of this metabolic gene network is conserved in the human parasite, Strongyloides stercoralis, and inhibition of specific steps in this network blocks reproductive growth in both of the nematodes. Our study provides a molecular understanding for metabolic adaptation of nematodes to their environment, and suggests a new therapeutic strategy for treating parasitic diseases.

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Section: Introductionmentioning

confidence: 99%

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

et al. 2015

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“…They are also extremely active, and like the infective larvae of S. papillosa (Costello & Grollman, 1958) they have a very high metabolic rate (unpublished results). Costello & Grollman (1958) have pointed out that there is an inverse relationship between the metabolic rate and the longevity of different nematode larvae; but Wilson (1965) has cast doubt on some of their conclusions. It is, however, interesting to note the inverse relationship between the rate of activity and the survival of the infective larvae of S. ratti.…”

Section: Discussionmentioning

confidence: 93%

The effect of temperature on the development and survival of the infective larvae of Strongyloides ratti Sandground, 1925

Barrett

1968

Parasitology

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The development of the free-living infective larvae of a homogonic strain Strongyloides ratti is described.The larvae develop only between 15 and 34 °C. Transfer experiments show the temperature block to be in the preparation for the second moult.Within the temperature range 15–34 °C, increasing the temperature speeds up the rate of development of all the larval stages equally, the Q10 for development being 2·5.The maximum percentage development occurs at 20 °C. The percentage development is highest in faeces–peat culture (95% development at 20 °C), whilst the percentage development in charcoal and vermiculite cultures is about the same (75% development at 20 °C.).Larvae grown on charcoal cultures are larger than those grown on vermiculite, which are larger than those grown on peat. No significant difference was found in the length:oesophagus and length:width ratios or in the variability of larvae grown at different temperatures or on different culture media.Different worm densities in the cultures of from 2000 to 10000 larvae per g of culture did not affect either the size of the infective larve or the percentage development.The optimum temperature for survival is 15 °C. Worms grown at 20 °C lived longer than worms grown at any other temperature. There was no evidence of temperature adaptation by the larvae.The infective larvae are positively thermotactic, and show maximum activity at 37 °C.I should like to thank my supervisor, Dr Tate, for his advice and encouragement. The work was carried out during the tenure of a Medical Research Council Scholarship.

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“…4b). Costello and Grollman (1958), had argued that the metabolic rate (Q0 2 ) of infective larvae was inversely related to their longevity and Barrett (1968b), showed that excessive locomotory activity by the larvae increased their metabolic rates and also resulted in reduced longevity. However, larvae stored under constant conditions as prevailed in these studies, have been shown to be relatively inactive (Croll and Al-Hadithi, 1972).…”

Section: Discussionmentioning

confidence: 99%

Determinants of the longevity of third-stage infective larvae of Ancylostoma tubaeforme

Nwosu

1979

J. Helminthol.

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The effects of some extrinsic factors on the lipid (energy) reserves and longevity of third-stage larvae of the cat hookworm Ancylostoma tubaeforme, were investigated under controlled laboratory conditions. In non-stressful microenvironmental conditions, larval longevity was directly related to the rate of utilisation of the lipid reserves. The effects of the various environmental stresses on longevity could also be explained largely on the basis of their deleterious effects on the lipid metabolism of the larvae.

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Oxygen requirements of Strongyloides papillosus infective larvae

Cited by 11 publications

References 17 publications

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

The effect of temperature on the development and survival of the infective larvae of Strongyloides ratti Sandground, 1925

Determinants of the longevity of third-stage infective larvae of Ancylostoma tubaeforme

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