Oxygen Radical Generation and Acute Pancreatitis

The Effect of Tin Compounds on the Lipid Peroxidation Level of Russian Sturgeon Fresh and Cryopreserved Sperm

“…The production of ROS in the presence of (n-C 4 H 9 ) 2 SnCl 2 and (C 6 H 5 ) 3 SnCl has been reported (Chantong et al, 2014;De Castro et al, 2018). Literature data indicate that the activity of the antioxidant enzyme superoxide dismutase decreased under the action of (n-C 4 H 9 ) 2 SnCl 2 (Weber et al, 1995). It should be also taken into account that sperm is particularly rich in mitochondria, which may predispose these cells to enhanced effects of OTs, because the mitochondria is the major cellular location for ROS generation upon stress (Doherty and Irwi, 2011).…”

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

“…However, the mechanisms whereby ethanol exerts its deleterious effects are still relatively poorly understood (Clemens et al, 2016). Early animal experimental findings from acute ethanol administration via various routes have shown that alcohol increases pancreatic duct permeability, reduces pancreatic blood flow and microcirculation (Friedman et al, 1983;Foitzik et al, 1998), decreases pancreatic oxygen consumption (Foitzik et al, 1995), and induces oxidative stress (Weber et al, 1995). Whereas, ethanol alone fails to cause AP, which is in line with the human disease: since <5% alcoholics will develop clinical AP (Forsmark et al, 2016).…”