Oxygen Pre-Conditioning Prevents Contrast-Induced Nephropathy (OPtion CIN Study)

Sekiguchi, Hiroyuki; Uchida, Yuzo; Ishida, Issei; Otsuki, Hisao; Hattori, Hidetoshi; Arashi, Hiroyuki; Kobayashi, Yasunori; Jujo, Kentaro; Yamaguchi, Junichi; Masaaki,; Iwade, Kazunori; Tanaka, Naohide; Shimamoto, Ken; Tsurumi, Yukio; Kawana, Masatoshi; Hagiwara, Nobuhisa

doi:10.1016/j.jacc.2013.04.012

Cited by 14 publications

(11 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings were inconsistent with previous studies. In the study of Minoo et al, the prevalence of CIN in individuals undergoing oxygen therapy were significantly lower than control group (18.6% versus 41.5%) (17), while in the study of Sekiguchi et al, the results were the same with the study by Minoo et al (0.6% versus 5.1%) (16). The type of procedure in our study was emergency, while the two previous studies have been performed electively and the hemodynamic status of the patients was stable, in such a way that the risk of CIN is less in elective patients from those of in emergency patients.…”

Section: Discussionmentioning

confidence: 70%

“…Since CIN begins immediately after the exposure to the contrast agent, it is assumed that adequate oxygenation before exposure to the contrast accompanied with hydration by isotonic saline can prevent CIN more effectively. Recent studies have also suggested that the addition of supplemental oxygen to hydration leads to a significant reduction in CIN development from that of hydration alone (16,17).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of oxygen therapy to ameliorate contrast-induced nephropathy in patients with acute coronary syndrome undergoing emergency angiography; a double-blinded clinical trial

et al. 2019

View full text Add to dashboard Cite

Introduction: Contrast-induced nephropathy (CIN) is one of the major causes of acute kidney injury. Objectives: Regarding an increase in mortality and morbidity in patients with CIN, this study aimed to evaluate the effect of oxygen therapy in prevention of the CIN in individuals with acute coronary syndrome undergoing emergent angiography. Patients and Methods: This study was a double-blinded clinical trial with control group (parallel design), randomized, and with a sample size of 204 individuals conducted on male or female patients over 35 years old and suspected of coronary artery disease undergoing emergent angiography refereed to Rasoul Akram hospital in 2018. Participants were divided into 2 groups (supplementary oxygen and oxygen-free groups). The first group received two to three liters of oxygen per minute from 10 minutes before the start of the procedure until the end of the procedure, and the second group inhaled the oxygen in the room air. Arterial blood gas (ABG) was taken prior to receiving oxygen and at the end of the procedure. Serum creatinine level was tested for all individuals before and 48 hours after the procedure. Results: The mean age in intervention and control groups was 61.66 ± 14.64 years and 60.49 ± 11.59 years, respectively (P=0.54). Mean glomerular filtration rate (GFR) and serum creatinine before and after angiography was not significantly different (P>0.05). There was a significant difference between the two genders regarding the development of CIN (P=0.002), which was higher in women from that of men. Female gender was a strong risk factor and approximately increased four times the risk of CIN (OR = 4.1; (P=0.001). History of chronic kidney disease (CKD) and hypertension (HTN) also produced such a situation (OR = 22.37; P=0.007). Conclusion: According to the results, oxygen therapy has no effect on the occurrence of CIN. It is also found that female gender, history of CKD and hypertension are risk factors for CIN.

show abstract

Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Impact of oxygen therapy to ameliorate contrast-induced nephropathy in patients with acute coronary syndrome undergoing emergency angiography; a double-blinded clinical trial

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Please note that the very high creatinine clearance values for the first sampling period following CM (0-10 min, depicted as grey shadows) do not represent actual increases in glomerular filtration rate, but rely on the dead-space effect (see Results). [2,20,28,29,[32][33][34][35]. Hypoxia is part of a vicious circle that entails cellular damage, oxidative stress and vasoconstriction [2,28,29].…”

Section: Issn: 2380-0585mentioning

confidence: 99%

Comparison of the Effects of Iodixanol and Iopamidol on Urine Flow, Urine Viscosity, and Glomerular Filtration in Rats

2015

J Urol Nephrol

View full text Add to dashboard Cite

Dehydration is a major risk for contrast media (CM) induced acute kidney injury, yet prospective studies in human patients without ample hydration are not feasible. The freely drinking rat can serve as a model for hydropenic humans.We compared the effects of two CM, iso-osmolar iodixanol and lowosmolar iopamidol, on urine flow, urine viscosity and glomerular filtration rate (GFR) in non-hydrated rats, and studied the impact of hydration by saline. In four groups of rats, either iodixanol 320 mg iodine/mL or iopamidol 370 mg iodine/mL was injected as 1.5 mL bolus into the thoracic aorta. Two groups had access to drinking water only and two groups received additional saline infusion (4 mL/hour per kg) starting 60 min before CM injection. Urine was collected (10 min sampling periods), urine viscosity measured, and GFR determined by creatinine clearance. In nonprehydrated rats, iodixanol led to a massive increase in urine viscosity and a transient 50% drop in GFR. Iopamidol had a much stronger diuretic effect than iodixanol, urine viscosity increased much less and GFR was unaffected. Saline infusion blunted the viscosity rise and transient decline in GFR caused by iodixanol. It is concluded that the choice of CM and ample hydration are important elements in the prevention of CM induced kidney injury. Low-osmolar iopamidol has a better renal safety profile than iso-osmolar iodixanol, at least in non-hydrated subjects. Hydration by saline counteracts the renal tubular concentration of CM thereby alleviating the increase in urine viscosity and the decline in GFR.

show abstract

“…Sekiguchi et al [58] randomly allocated 349 eligible patients who underwent elective coronary angiography and/or percutaneous coronary intervention to either an oxygenation group (oxygen administration via nasal cannula; 2 L/min of oxygen from 10 min before the procedure to the end of the procedure; n = 174) or to a control group (room air; n = 175). Continuous infusion of isotonic saline solution (1 mL/kg/hour) was administered 12 hours before the procedure until 12 hours after the procedure in both groups.…”

Section: Nonpharmacological Strategies To Prevent Ci-akimentioning

confidence: 99%

Nonpharmacological Strategies to Prevent Contrast-Induced Acute Kidney Injury

Susantitaphong

Eiam‐Ong

2014

BioMed Research International

View full text Add to dashboard Cite

Contrast-induced AKI (CI-AKI) has been one of the leading causes for hospital-acquired AKI and is associated with independent risk for adverse clinical outcomes including morbidity and mortality. The aim of this review is to provide a brief summary of the studies that focus on nonpharmacological strategies to prevent CI-AKI, including routine identification of at-risk patients, use of appropriate hydration regimens, withdrawal of nephrotoxic drugs, selection of low-osmolar contrast media or isoosmolar contrast media, and using the minimum volume of contrast media as possible. There is no need to schedule dialysis in relation to injection of contrast media or injection of contrast agent in relation to dialysis program. Hemodialysis cannot protect the poorly functioning kidney against CI-AKI.

show abstract

Oxygen Pre-Conditioning Prevents Contrast-Induced Nephropathy (OPtion CIN Study)

Cited by 14 publications

References 3 publications

Impact of oxygen therapy to ameliorate contrast-induced nephropathy in patients with acute coronary syndrome undergoing emergency angiography; a double-blinded clinical trial

Impact of oxygen therapy to ameliorate contrast-induced nephropathy in patients with acute coronary syndrome undergoing emergency angiography; a double-blinded clinical trial

Comparison of the Effects of Iodixanol and Iopamidol on Urine Flow, Urine Viscosity, and Glomerular Filtration in Rats

Nonpharmacological Strategies to Prevent Contrast-Induced Acute Kidney Injury

Contact Info

Product

Resources

About