Oxygen-powered flower-like FeMo<sub>6</sub>@CeO<sub>2</sub> self-cascade nanozymes: a turn-on enhancement fluorescence sensor

Tong, Zhibo; Wang, Tong; Cai, Yunheng; Sha, Jingquan; Peng, Tai

doi:10.1039/d2tb01466a

Cited by 5 publications

(5 citation statements)

References 61 publications

(65 reference statements)

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“…Based on these findings, the proposed detection mechanism, as illustrated in Figure , enables colorimetric sensing of valine, leucine, and isoleucine using the developed method. When the imprinted nanozyme arrays come into contact with the persulfate oxidizing and chromogenic tracer solution at an optimal pH of 4.5, the presence of cerium and iron species with different oxidation numbers on the nanozymes initiates a Fenton-like process, resulting in the generation of persulfate radicals. , The persulfate radicals have attracted considerable attention due to their strong redox potential, similar to that of • OH radicals. Persulfate can be converted to • OH, which exhibits a slightly higher redox potential than persulfate (See Figure ).…”

Section: Resultsmentioning

confidence: 99%

Prussian Blue Analogues-Derived Molecularly Imprinted Nanozyme Array for Septicemia Detection

Dashtian,

Afshar Gheshlaghi,

Zare-Dorabei

et al. 2024

ACS Appl. Bio Mater.

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Septicemia, a severe bacterial infection, poses significant risks to human health. Early detection of septicemia by tracking specific biomarkers is crucial for a timely intervention. Herein, we developed a molecularly imprinted (MI) TiO 2 −Fe−CeO 2 nanozyme array derived from Ce[Fe(CN) 6 ] Prussian blue analogues (PBA), specifically targeting valine, leucine, and isoleucine, as potential indicators of septicemia. The synthesized nanozyme arrays were thoroughly characterized using various analytical techniques, including Fourier transform infrared spectroscopy, X-ray diffraction, fieldemission scanning electron microscope, and energy-dispersive X-ray. The results confirmed their desirable physical and chemical properties, indicating their suitability for the oxidation of 3,3′,5,5′-tetramethylbenzidine serving as a colorimetric probe in the presence of a persulfate oxidizing agent, further highlighting the potential of these arrays for sensitive and accurate detection applications. The MITiO 2 shell selectively captures valine, leucine, and isoleucine, partially blocking the cavities for substrate access and thereby hindering the catalyzed TMB chromogenic reaction. The nanozyme array demonstrated excellent performance with linear detection ranges of 5 μM to 1 mM, 10−450 μM, and 10−450 μM for valine, leucine, and isoleucine, respectively. Notably, the corresponding limit of detection values were 0.69, 1.46, and 2.76 μM, respectively. The colorimetric assay exhibited outstanding selectivity, reproducibility, and performance in the detection of analytes in blood samples, including C-reactive protein at a concentration of 61 mg/L, procalcitonin at 870 ng/dL, and the presence of Pseudomonas aeruginosa bacteria. The utilization of Ce[Fe(CN) 6 ]-derived MITiO 2 − Fe−CeO 2 nanozyme arrays holds considerable potential in the field of septicemia detection. This approach offers a sensitive and specific method for early diagnosis and intervention, thereby contributing to improved patient outcomes.

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Section: Resultsmentioning

confidence: 99%

Prussian Blue Analogues-Derived Molecularly Imprinted Nanozyme Array for Septicemia Detection

Dashtian,

Afshar Gheshlaghi,

Zare-Dorabei

et al. 2024

ACS Appl. Bio Mater.

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“…As a result, ROS was continuously generated when cysteine existed and consequently contributed to enhanced fluorescence. This "turn-on enhanced" selfcascade sensing platform has high sensitivity for cysteine detection of the limit of 0.014 × 10 −3 m and detection range of 1 × 10 −3 to 100 × 10 −3 m. [223]…”

Section: Small Moleculesmentioning

confidence: 99%

“…This “turn‐on enhanced” self‐cascade sensing platform has high sensitivity for cysteine detection of the limit of 0.014 × 10 −3 m and detection range of 1 × 10 −3 to 100 × 10 −3 m . [ 223 ]…”

Section: Applications Of Multienzymic Nanozymesmentioning

confidence: 99%

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Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Sheng

Ding

et al. 2023

Advanced Materials

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Nanomaterials with more than one enzyme‐like activity are termed multi‐enzymic nanozymes, which have received increasing attention in recent years and hold huge potential to be applied in diverse fields, especially for biosensing and therapeutics. Compared to single enzyme‐like nanozymes, multi‐enzymic nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, and environmentally‐responsive selectivity. Nevertheless, along with these merits, the catalytic mechanism and rational design of multi‐enzymic nanozymes are more complicated and elusive as compared to single‐enzymic nanozymes. In this review, we systematically discussed the multi‐enzymic nanozymes classification scheme based on the numbers/types of activities, the internal and external factors regulating the multi‐enzymatic activities, the rational design based on chemical, biomimetic, and computer‐aided strategies, and recent progress in applications attributed to the advantages of multi‐catalytic activities. Finally, current challenges and future perspectives regarding the development and application of multi‐enzymatic nanozymes are suggested. This review aims to deepen the understanding and inspire the research in multi‐enzymic nanozymes to a greater extent.This article is protected by copyright. All rights reserved

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“…In the context of fermented foods, controlling oxygen levels is crucial for microbial growth; inadequate dissolved oxygen can lead to slow microbial growth. , Given the importance of oxygen in human life, it is necessary to develop a fast, accurate, and cost-effective dissolved-oxygen sensor for oxygen measurements in fields such as medicine, aquaculture, and environmental monitoring. Various methods have been proposed for measuring dissolved-oxygen levels, including iodimetry, electrochemical methods, and fluorescence analysis. − Iodimetry has high accuracy, but is time-consuming because of its complexity; hence, it is not suitable for real-time monitoring . Electrochemical methods offer instant detection but require continuous stirring to allow oxygen to spread through a film.…”

Section: Introductionmentioning

confidence: 99%

Facile Fabrication and Analysis of Highly Sensitive PtTFPP/Carbon Black/Polystyrene Oxygen-Sensitive Composite Films for Optical Dissolved-Oxygen Sensor

Lee,

Li,

Cheng

et al. 2024

ACS Appl. Electron. Mater.

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This research has designed and fabricated an oxygen-sensitive composite film, based on fluorescence quenching by oxygen, which can be applied in optical dissolved-oxygen sensor probes. The composite film is prepared by mixing polystyrene (PS) and indicator dye (platinum tetrakis pentrafluorophenyl porphine, PtTFPP). Tributyl phosphate (TBP) and common black pigment (i.e., carbon black, CB) are then added to enhance the oxygen permeability and specific surface area of the film and to increase its oxygen sensitivity. A nonionic surfactant (i.e., Triton X-100) is used to facilitate the uniform dispersion of carbon black within the PtTFPP/PS composite film, producing a highly oxygen-sensitive film. This research shows that the highest sensitivity (I 0 /I 100 ) is achieved at a weight ratio of 150:1 (PS/PtTFPP), with a linear correlation coefficient (R 2 ) of 0.9955. With the addition of 3 wt % TBP to PS, the sensitivity increases to 16.51, with an R 2 value of 0.9939. The addition of CB to this film increases the sensitivity further to 19.12 (R 2 = 0.9916). The above results show that the addition of TBP and CB can effectively enhance the oxygen sensitivity of the film. This study successfully fabricates an oxygensensitive compound film with high oxygen sensitivity and detection accuracy in a simple and cost-effective manner. The methods used in this study can be used for developing other highly sensitive sensors, which can be used in professional water-quality assessments for commercial purposes.

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Oxygen-powered flower-like FeMo₆@CeO₂ self-cascade nanozymes: a turn-on enhancement fluorescence sensor

Abstract: Enzyme cascade reactions in organisms have sparked tremendous interest for their coupled catalysis-facilitated efficient biochemical reactions. However, multi-enzyme cascade nanozymes remain largely unpracticed. In the work, flower-like porous ceria-based integrated...

Cited by 5 publications

References 61 publications

Prussian Blue Analogues-Derived Molecularly Imprinted Nanozyme Array for Septicemia Detection

Prussian Blue Analogues-Derived Molecularly Imprinted Nanozyme Array for Septicemia Detection

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Facile Fabrication and Analysis of Highly Sensitive PtTFPP/Carbon Black/Polystyrene Oxygen-Sensitive Composite Films for Optical Dissolved-Oxygen Sensor

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Oxygen-powered flower-like FeMo6@CeO2 self-cascade nanozymes: a turn-on enhancement fluorescence sensor

Abstract: Enzyme cascade reactions in organisms have sparked tremendous interest for their coupled catalysis-facilitated efficient biochemical reactions. However, multi-enzyme cascade nanozymes remain largely unpracticed. In the work, flower-like porous ceria-based integrated...

Cited by 5 publications

References 61 publications

Prussian Blue Analogues-Derived Molecularly Imprinted Nanozyme Array for Septicemia Detection

Prussian Blue Analogues-Derived Molecularly Imprinted Nanozyme Array for Septicemia Detection

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Facile Fabrication and Analysis of Highly Sensitive PtTFPP/Carbon Black/Polystyrene Oxygen-Sensitive Composite Films for Optical Dissolved-Oxygen Sensor

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Product

Resources

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Oxygen-powered flower-like FeMo₆@CeO₂ self-cascade nanozymes: a turn-on enhancement fluorescence sensor