Oxygen Metabolism-induced Stress Response Underlies Heart–brain Interaction Governing Human Consciousness-breaking and Attention

Xue, Xiao-Juan; Su, Rui; Li, Zefeng; Bu, Xiao-Ou; Dang, Peng; Yu, Sifang; Wang, Zhi-Xin; Chen, Dongmei; Zeng, Tong-Ao; Liu, Ming; Ma, Hua; Zhang, De‐Long

doi:10.1007/s12264-021-00761-1

Cited by 10 publications

(9 citation statements)

References 79 publications

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“…Another study also found that the red blood cells of physically active rats were more resistant to oxidative stress after they were deprived of oxygen [73]. Our previous study found that healthy RBC at high altitude can support the immune system [40]. Our results here showed that individuals with high CRF levels had larger hippocampal and amygdala volumes than those with low CRF levels, possibly because individuals with high CRF levels have higher oxygen transport capacity and higher immune levels.…”

Section: Discussionsupporting

confidence: 66%

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Changes in Hippocampus and Amygdala Volume with Hypoxic Stress Related to Cardiorespiratory Fitness under a High-Altitude Environment

Wang

et al. 2022

Brain Sciences

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The morphology of the hippocampus and amygdala can be significantly affected by a long-term hypoxia-induced inflammatory response. Cardiorespiratory fitness (CRF) has a significant effect on the neuroplasticity of the hippocampus and amygdala by countering inflammation. However, the role of CRF is still largely unclear at high altitudes. Here, we investigated brain limbic volumes in participants who had experienced long-term hypoxia exposure in Tibet (3680 m), utilizing high-resolution structural images to allow the segmentation of the hippocampus and amygdala into their constituent substructures. We recruited a total of 48 participants (48 males; aged = 20.92 ± 1.03 years) to undergo a structural 3T MRI, and the levels of maximal oxygen uptake (VO2max) were measured using a cardiorespiratory function test. Inflammatory biomarkers were also collected. The participants were divided into two groups according to the levels of median VO2max, and the analysis showed that the morphological indexes of subfields of the hippocampus and amygdala of the lower CRF group were decreased when compared with the higher CRF group. Furthermore, the multiple linear regression analysis showed that there was a higher association with inflammatory factors in the lower CRF group than that in the higher CRF group. This study suggested a significant association of CRF with hippocampus and amygdala volume, which may be related to hypoxic stress in high-altitude environments. A better CRF reduced physiological stress and a decrease in the inflammatory response was observed, which may be related to the increased oxygen transport capacity of the body.

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Section: Discussionsupporting

confidence: 66%

“…The biochemical indicators related to inflammation were collected from the participants by venous blood sampling in Fukang Hospital, affiliated with Tibet University (Lhasa, Tibet), corresponding to a previous study in our lab [40].…”

Section: Biochemical Indicatorsmentioning

confidence: 99%

Changes in Hippocampus and Amygdala Volume with Hypoxic Stress Related to Cardiorespiratory Fitness under a High-Altitude Environment

Wang

et al. 2022

Brain Sciences

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“…Oxidative stress injury occurs when people suffered from exogenous acute or chronic stress, leading to cell dysfunction and apoptosis ( Rohleder, 2019 ; Forman and Zhang, 2021 ; Xue et al, 2022 ). The level of oxidative stress-related markers in the serum is found to be altered in the serum of patients with memory impairment ( Du et al, 2019 ; Torres et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Fresh Gastrodia elata Blume alleviates simulated weightlessness-induced cognitive impairment by regulating inflammatory and apoptosis-related pathways

et al. 2023

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In aerospace medicine, the influence of microgravity on cognition has always been a risk factor threatening astronauts’ health. The traditional medicinal plant and food material Gastrodia elata Blume has been used as a therapeutic drug for neurological diseases for a long time due to its unique neuroprotective effect. To study the effect of fresh Gastrodia elata Blume (FG) on cognitive impairment caused by microgravity, hindlimb unloading (HU) was used to stimulate weightlessness in mice. The fresh Gastrodia elata Blume (0.5 g/kg or 1.0 g/kg) was intragastrically administered daily to mice exposed to HU and behavioral tests were conducted after four weeks to detect the cognitive status of animals. The behavioral tests results showed that fresh Gastrodia elata Blume therapy significantly improved the performance of mice in the object location recognition test, Step-Down test, and Morris Water Maze test, including short-term and long-term spatial memory. According to the biochemical test results, fresh Gastrodia elata Blume administration not only reduced serum factor levels of oxidative stress but also maintained the balance of pro-inflammatory and anti-inflammatory factors in the hippocampus, reversing the abnormal increase of NLRP3 and NF-κB. The apoptosis-related proteins were downregulated which may be related to the activation of the PI3K/AKT/mTOR pathway by fresh Gastrodia elata Blume therapy, and the abnormal changes of synapse-related protein and glutamate neurotransmitter were corrected. These results identify the improvement effect of fresh Gastrodia elata Blume as a new application form of Gastrodia elata Blume on cognitive impairment caused by simulated weightlessness and advance our understanding of the mechanism of fresh Gastrodia elata Blume on the neuroprotective effect.

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“…The body improves the efficiency of oxygen carrying and delivery by compensatory increase in the number of erythrocytes to maintain the normal function of tissues (Wood and Johansen, 1972 ; Raberin et al, 2022 ; Villafuerte et al, 2022 ). However, in recent years, it has been shown that such compensatory changes in red blood cells (RBCs) in immigrant populations living at high-altitude may not only involve the physiological aspects of oxygen transport, but also relate to cognitive functions such as attention (Xue et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The neuroimmune pathway of high-altitude adaptation: influence of erythrocytes on attention networks through inflammation and the autonomic nervous system

Wang,

Yu,

Dang

et al. 2024

Front. Neurosci.

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IntroductionMany studies have shown that the functional adaptation of immigrants to high-altitude is closely related to oxygen transport, inflammatory response and autonomic nervous system. However, it remains unclear how human attention changes in response to hypoxia-induced neurophysiological activity during high-altitude exposure.MethodsIn the present study, we analyzed the relationship between hypoxic-induced neurophysiological responses and attention networks in 116 immigrants (3,680 m) using an attention network test to simultaneously record electroencephalogram and electrocardiogram in combination with specific routine blood markers.ResultsOur analysis revealed that red blood cells exert an indirect influence on the three attention networks, mediated through inflammatory processes and heart rate variability.DiscussionThe present study provides experimental evidence for the role of a neuroimmune pathway in determining human attention performance at high- altitude. Our findings have implications for understanding the complex interactions between physiological and neurocognitive processes in immigrants adapting to hypoxic environments.

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Oxygen Metabolism-induced Stress Response Underlies Heart–brain Interaction Governing Human Consciousness-breaking and Attention

Cited by 10 publications

References 79 publications

Changes in Hippocampus and Amygdala Volume with Hypoxic Stress Related to Cardiorespiratory Fitness under a High-Altitude Environment

Changes in Hippocampus and Amygdala Volume with Hypoxic Stress Related to Cardiorespiratory Fitness under a High-Altitude Environment

Fresh Gastrodia elata Blume alleviates simulated weightlessness-induced cognitive impairment by regulating inflammatory and apoptosis-related pathways

The neuroimmune pathway of high-altitude adaptation: influence of erythrocytes on attention networks through inflammation and the autonomic nervous system

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