Oxygen Mass Transport in Stented Coronary Arteries

Murphy, Eóin; Dunne, Adrian S.; Martín, David; Boyle, Fergal J.

doi:10.1007/s10439-015-1501-6

Cited by 4 publications

(7 citation statements)

References 26 publications

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“…These studies have also examined the importance of non-Newtonian blood flow modelling on transport and found non-Newtonian effects to be of minor importance. For models of oxygen transport, the early paper of Crawford et al [88], followed by the study of Moore & Ethier [89] and more recently Murphy et al [90] are representative of developments in oxygen transport modelling. Tarbell [91] presented a simplified single layer model that is summarized in figure 4.…”

Section: Transport From the Lumenmentioning

confidence: 99%

“…However, PTA with stenting is often complicated by in-stent restenosis secondary to neointimal hyperplasia, which may result in failure of the implant. Although restenosis is linked to different aspects of the procedure, recent studies have highlighted the relationship between reduced levels of oxygen tension within the stented artery wall and intimal hyperplasia [90,[104][105][106][107]. The stent itself plays a key role in determining the overall oxygen supply to the underlying tissue.…”

Section: Stent Hypoxiamentioning

confidence: 99%

“…This increased demand for oxygen can lead to a supply limitation from the blood phase as discussed in the context of figure 2. In addition, inner wall hypoxia may be associated with reduced fluid phase transport driven by local flow separation around stent struts [90,111]. The endothelial layer is also damaged during stenting [112], but the endothelium itself offers very little resistance to oxygen transport and is not expected to be influential in controlling wall hypoxia [91].…”

Section: Stent Hypoxiamentioning

confidence: 99%

“…Previous studies have used finite-element analysis (FEA) to investigate the mechanical interaction between expanded stents and atherosclerotic tissues [118][119][120]. Others have focused on the influence of the implant design on the haemodynamics and oxygen transport rates through the stented lumen [90,117].…”

Section: Deformation Of Vasa Vasorum After Stentingmentioning

confidence: 99%

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The role of oxygen transport in atherosclerosis and vascular disease

Tarbell

Mahmoud

Corti

et al. 2020

J. R. Soc. Interface.

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Atherosclerosis and vascular disease of larger arteries are often associated with hypoxia within the layers of the vascular wall. In this review, we begin with a brief overview of the molecular changes in vascular cells associated with hypoxia and then emphasize the transport mechanisms that bring oxygen to cells within the vascular wall. We focus on fluid mechanical factors that control oxygen transport from lumenal blood flow to the intima and inner media layers of the artery, and solid mechanical factors that influence oxygen transport to the adventitia and outer media via the wall's microvascular system—the vasa vasorum (VV). Many cardiovascular risk factors are associated with VV compression that reduces VV perfusion and oxygenation. Dysfunctional VV neovascularization in response to hypoxia contributes to plaque inflammation and growth. Disturbed blood flow in vascular bifurcations and curvatures leads to reduced oxygen transport from blood to the inner layers of the wall and contributes to the development of atherosclerotic plaques in these regions. Recent studies have shown that hypoxia-inducible factor-1α (HIF-1α), a critical transcription factor associated with hypoxia, is also activated in disturbed flow by a mechanism that is independent of hypoxia. A final section of the review emphasizes hypoxia in vascular stenting that is used to enlarge vessels occluded by plaques. Stenting can compress the VV leading to hypoxia and associated intimal hyperplasia. To enhance oxygen transport during stenting, new stent designs with helical centrelines have been developed to increase blood phase oxygen transport rates and reduce intimal hyperplasia. Further study of the mechanisms controlling hypoxia in the artery wall may contribute to the development of therapeutic strategies for vascular diseases.

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Section: Transport From the Lumenmentioning

confidence: 99%

Section: Stent Hypoxiamentioning

confidence: 99%

Section: Stent Hypoxiamentioning

confidence: 99%

Section: Deformation Of Vasa Vasorum After Stentingmentioning

confidence: 99%

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The role of oxygen transport in atherosclerosis and vascular disease

Tarbell

Mahmoud

Corti

et al. 2020

J. R. Soc. Interface.

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“…In numerous previous computational studies of oxygen mass transfer in blood vessels, two approaches were utilized: (i) oxygen transport as a free species in plasma [ 7 , 23 , 26 , 29 , 30 , 33 , 34 ] and (ii) oxygen transport by haemoglobin [ 27 , 28 , 31 , 32 , 35 , 36 ]. It was suggested that the inclusion of haemoglobin-mediated oxygen transport was essential to obtain a proper representation of oxygen mass transfer in blood vessels [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

On the identification of hypoxic regions in subject-specific cerebral vasculature by combined CFD/MRI

2023

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A long-time exposure to lack of oxygen (hypoxia) in some regions of the cerebrovascular system is believed to be one of the causes of cerebral neurological diseases. In the present study, we show how a combination of magnetic resonance imaging (MRI) and computational fluid dynamics (CFD) can provide a non-invasive alternative for studying blood flow and transport of oxygen within the cerebral vasculature. We perform computer simulations of oxygen mass transfer in the subject-specific geometry of the circle of Willis. The computational domain and boundary conditions are based on four-dimensional (4D)-flow MRI measurements. Two different oxygen mass transfer models are considered: passive (where oxygen is treated as a dilute chemical species in plasma) and active (where oxygen is bonded to haemoglobin) models. We show that neglecting haemoglobin transport results in a significant underestimation of the arterial wall mass transfer of oxygen. We identified the hypoxic regions along the arterial walls by introducing the critical thresholds that are obtained by comparison of the estimated range of Damköhler number ( Da ⊂ 〈9; 57〉) with the local Sherwood number. Finally, we recommend additional validations of the combined MRI/CFD approach proposed here for larger groups of subject- or patient-specific brain vasculature systems.

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