Oxygen Isotope Separation

18 O-labeled water (Water-18 O) is a widely used starting material of 18 F-labeled diagnostic agents in positron emission tomography (PET). Conventionally, Water-18 O has been separated from other stable oxygen isotope species ( 16 O, 17 O) by water distillation or nitric oxide distillation. However, conventional methods are costly and may have safety issues. In 2004, we developed the first unit of our novel oxygen isotope separation process by cryogenic oxygen distillation to overcome these issues. To meet the needs of the market, we built a second unit in 2013 and a third in 2016. We are now operating three commercially viable separation units with a total capacity of 600 kg of Water-18 O per year.

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Industrial separation of oxygen isotopes by oxygen distillation

Igarashi

Kambe

Kihara

2019

Labelled Comp Radiopharmac

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Oxygen Isotope Separation

Cited by 1 publication

References 12 publications

Industrial separation of oxygen isotopes by oxygen distillation

Industrial separation of oxygen isotopes by oxygen distillation

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