Oxygen inhalation induced changes in the skin as measured by transcutaneous oxymetry

McCollum, P. T.; Spence, V. A.; Walker, William F.

doi:10.1002/bjs.1800731108

Cited by 35 publications

(4 citation statements)

References 10 publications

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“…When adequate C‐fibre activity is present, the oxygen tension will be higher than when there is reduced C‐fibre activity (15). In support of this proposition, skin oxygen tension correlates well with healing rates (34–36). When sensors are at 39°C, the measured oxygen tension reflects basal oxygen tension (15).…”

Section: Discussionmentioning

confidence: 79%

Use of the sensory nerve stimulator to accelerate healing of a venous leg ulcer with sensory nerve dysfunction: a case study

Ogrin

Dārziņš

Khalil

2005

International Wound Journal

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A new therapy using sensory nerve stimulation [International Patent Application Number PCT/AU2004/001079: "nerve function and tissue healing" (Khalil, Z)] has been developed in our vascular physiology laboratory. This treatment has been found to improve the deficient sensory nerve function and associated deficient wound healing of older persons to levels seen in young people. An 82-year-old man with a small but persistent venous leg ulcer for 18 months, despite apparently appropriate wound dressings and compression therapy, was seen in a specialist wound management service. The patient's sensory and microvascular function was assessed in great detail using the vascular physiology laboratory techniques, and he was provided the sensory nerve stimulation therapy in addition to conventional therapy. His wound healed after 4 weeks. We report the case here. Prior to nerve stimulation therapy, cutaneous sensation, microvascular blood flow and oxygen tension were found to be reduced near the ulcer when compared with the opposite, non ulcerated leg. After therapy, oxygen tension and microvascular blood flow had improved. This case provides further evidence that sensory nerve stimulation therapy at the stipulated parameters improves wound healing. The observation that sensory nerve function improved provides support for the notion that improvement in healing is mediated by improved nerve function.

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Section: Discussionmentioning

confidence: 79%

Use of the sensory nerve stimulator to accelerate healing of a venous leg ulcer with sensory nerve dysfunction: a case study

Ogrin

Dārziņš

Khalil

2005

International Wound Journal

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“…It is wrong to assume that a single preoperative level of TcpOz will predict success in every case and that adequate tissue oxygenation is the only requirement for a successful amputation. Some would argue that a better identification of potential success or failure can be achieved by measurements following some circulatory provocation such as exercise or oxygen inhaIation (Harward et al, 1985;McCollum et al, 1986). This has not yet been the authors' experience.…”

Section: Discussionmentioning

confidence: 99%

“…Doppler ultrasonic assessment of segmental pressure (Pollock and Ernst, 1980;Lepentalo et al, 1982;Cederberg et al, 1983), thermography (Spence et al, 1981), measurement of skin blood flow (Moore et al, 1981) and pressure (Holstein et al, 1979;Spence and Walker, 1984) have all been found to be of some value. More recently, with the advent of the skin oxygen electrode, transcutaneous PO;, (Tcp02) has been suggested as a more reliable indicator of the potential for healing (Franzeck et al, 1982;Burgess et al, 1982;Mustapha et al, 1983;Ratcliff et al, 1984;Katsamouris et al, 1984;Harward et al, 1985;McCollum et al, 1986).…”

Section: Roberts !Jeparfment Of Medicalmentioning

confidence: 99%

The effect of adjuvant oxygen therapy on transcutaneus p02 and healing in the below-knee amputee

Butler

Ham

Lafferty

et al. 1987

Prosthetics &Amp; Orthotics International

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The effects on tissue oxygenation of postoperative adjuvant oxygen have been studied in a group of 20 patients undergoing below-knee (BK) amputation for vascular disease. Ten patients received no therapy, the remainder receiving 28% oxygen for 48 hours following surgery. The results showed that the trancutaneous p02 in the amputation flaps fell significantly by some 20 mmHg (p<0.01) following surgery and that this fall was prevented by the use of adjuvant oxygen. The fall was not observed in the non-amputated limbs. Tcp02 took almost two weeks to reach its pre-operative levels in the amputated limbs. The effect on stump healing of adjuvant oxygen therapy was investigated in a randomized controlled trial in a series of 39 patients undergoing BK amputation. There were 22 patients in the control (untreated) group and 17 in the treated group (adjuvant oxygen for 48 hours). In the treated group 14 patients healed primarily and three amputations failed. In the untreated group 14 limbs healed primarily, one secondarily and there were 7 failures. The pre-operative transcutaneous values in the stumps which failed (26 mmHg±14) was significantly lower (p<0.005) than in those which healed (40 mmHg±9). The mean pre-operative Tcp02 in the patients in whom healing occurred in the treated group (35 mmHg±10) was significantly lower (p<0.001) than the mean pressure observed in the untreated group (44 mmHg±9).

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“…The initial clinical application of transcutaneous oxygen monitors (TCM) was to measure neonatal arterial oxygen tension. Currently, advocates promote oxygen tension measurement around wounds (8), in skin of people with venous oedema (9), in ischaemic limbs to assess limb amputation level (10), prediction of healing diabetes foot ulcers (11) and, more recently, to predict need for revascularisation to heal ischaemic diabetes foot ulcers (12) and to predict ischaemic ulcer healing (13). Confidence in use of skin oxygen tension monitors to monitor wound healing has been reduced in the past because of the variation in responses at different sensory temperatures (14–17).…”

Section: Introductionmentioning

confidence: 99%

Oxygen tension assessment: an overlooked tool for prediction of delayed healing in a clinical setting

Ogrin

Woodward

Sussman

et al. 2011

International Wound Journal

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Successful wound healing requires adequate transcutaneous oxygen tension (tcpO(2) ). TcpO(2) may not commonly be incorporated in clinical assessments because of variable measurement response at different sensory temperatures. This study aims to assess the relationship between changes in tcpO(2) , measured under basal (39°C) and stimulated (44°C) conditions and healing rate of chronic wounds over 4 weeks, to determine whether tcpO(2) measurement can predict delayed wound healing. TcpO(2) (Radiometer TCM400) measurements at sensor temperatures 39 and 44°C were recorded (twice, 4 weeks apart) adjacent to the ulcer site, and at a mirror image site on the contralateral leg. Ulcer outline was traced on clear acetate and perimeter and area measured (Visitrak™, Smith and Nephew). TcpO(2) measured at 44 and 39°C adjacent to all 13 wounds were lower compared to the contralateral site, significant at 44°C (P = 0·008). Significant correlation (r(2) = 0·8) occurred between wound healing rate and increased tcpO(2) at 44°C over 4 weeks. Importantly, the ratio of 39/44°C tcpO(2) , measured at the initial appointment, appeared to predict normal or delayed healing rate. TcpO(2) may provide clinicians with information regarding anticipated healing ability of wounds at the initial appointment, and hence identify wounds requiring early implementation of adjuvant therapies to accelerate healing.

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Oxygen inhalation induced changes in the skin as measured by transcutaneous oxymetry

Cited by 35 publications

References 10 publications

Use of the sensory nerve stimulator to accelerate healing of a venous leg ulcer with sensory nerve dysfunction: a case study

Use of the sensory nerve stimulator to accelerate healing of a venous leg ulcer with sensory nerve dysfunction: a case study

The effect of adjuvant oxygen therapy on transcutaneus p02 and healing in the below-knee amputee

Oxygen tension assessment: an overlooked tool for prediction of delayed healing in a clinical setting

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