Oxygen diffusion distance in thyroxine-induced hypertrophic rabbit myocardium

Seiden, David L.; Navidad, P.; Weiss, Harvey R.

doi:10.1016/s0022-2828(88)80146-9

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…Oxygen gradients emerged under conditions when cardiomyocytes were paced or treated with respiratory uncouplers. Although both interventions may appear as nonphysiological forms of stress, the observed oxygen gradients are likely to occur also in vivo in particular when oxygen becomes scarce or diffusion distances increase ( Seiden et al, 1988 ; Sabbah, 2017 ). A major limitation to date in validating the biological significance of such gradients in vivo is owed to a lack of suitable oxygen biosensors and imaging systems.…”

Section: The Emergence Of Oxygen Gradients Within Cardiomyocytesmentioning

confidence: 99%

“…Moreover, oxygen must pass through different layers of actively respiring mitochondria to reach the innermost contractile compartments to satisfy their need for cellular respiration. It stands to reason that adequate oxygen distribution is additionally compromised under conditions of increased workload such as pressure overload and hypertrophy ( Seiden et al, 1988 ; Sabbah, 2017 ), potentially rendering oxygen delivery a limiting determinant of ETS-driven redox responses. This would inevitably affect a number of processes intrinsically linked to ATP production including cellular redox balance, mitochondrial heat production and would eventually impair organ homeostasis and function ( Suomalainen and Battersby, 2017 ; Bertero and Maack, 2018 ) ( Figures 1B–D ).…”

Section: Introductionmentioning

confidence: 99%

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Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure

Szibor,

Mühlon,

Doenst

et al. 2023

Front. Mol. Med

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Cardiomyocytes depend on mitochondrial oxidative phosphorylation (OXPHOS) for energy metabolism, which is facilitated by the mitochondrial electron transfer system (ETS). In a series of thermogenic redox reactions, electrons are shuttled through the ETS to oxygen as the final electron acceptor. This electron transfer is coupled to proton translocation across the inner mitochondrial membrane, which itself is the main driving force for ATP production. Oxygen availability is thus a prerequisite for ATP production and consequently contractility. Notably, cardiomyocytes are exceptionally large cells and densely packed with contractile structures, which constrains intracellular oxygen distribution. Moreover, oxygen must pass through layers of actively respiring mitochondria to reach the ones located in the innermost contractile compartment. Indeed, uneven oxygen distribution was observed in cardiomyocytes, suggesting that local ATP supply may also vary according to oxygen availability. Here, we discuss how spatial adjustment of bioenergetics to intracellular oxygen fluctuations may underlie cardiac contractile adaptation and how this adaptation may pose a risk for the development of contractile failure.

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Section: The Emergence Of Oxygen Gradients Within Cardiomyocytesmentioning

confidence: 99%