Oxygen desaturation index as alternative parameter in screening patients with severe obstructive sleep apnea

Varghese, Lalee; Rebekah, Grace; Priya, Nidhi; Oliver, Ashwin; Kurien, Regi

doi:10.5935/1984-0063.20200119

Cited by 21 publications

(13 citation statements)

References 13 publications

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“…OSA is diagnosed and graded according to the frequency of Apnea-Hypopnea Index(AHI) observed during sleep, which the field of sleep medicine relies on [ 7 ]. The most common clinical manifestations of OSA are usually associated with symptoms such as snoring, inattention, excessive daytime sleepiness, fatigue, and cognitive decline, which is often associated with decreased blood oxygen saturation [ 8 ]. Untreated OSA is associated with adverse neurocognition (daytime sleepiness, reduced attention), vascular disorders (coronary heart disease, hypertension, stroke, congestive heart failure, and atherosclerosis), and metabolic disorders (hypertension, diabetes, stroke, impaired glucose tolerance, and insulin resistance) [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Incidence and risk of periodontitis in obstructive sleep apnea: A meta-analysis

Zhang

Zhai

et al. 2022

PLoS ONE

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Introduction At present, the possible relationship between obstructive sleep apnea and periodontitis has been reported. The link remains ambiguous and unclear. The objective of this study is to assess the association between OSA and periodontitis. Methods Three databases, including Pubmed, Embase, and the Web of Science, were systematically searched to identify eligible studies that from their establishment to February 2022 for relevant studies. Subsequently, a meta-analysis was conducted to determine the relationship of pooled-effects more accurately. Results A summary analysis of the 9 results from the studies covering 43,414 individuals showed a statistical association results of the between OSA and the incidence rate of periodontitis(OR = 0.52; 95% CI: 0.49–0.55; I2 = 98.43%; P = 0.000). In addition, OSA patients and the risk of the population were statistically significantly associated with an increased risk of periodontitis.(OR = 1.56; 95% CI: 1.06–2.06; P = 0.00). Conclusions Our results indicated that OSA may be associated with an increased risk of periodontitis. Further studies are required to confirm the link and explore the underlying mechanism of the link.

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Section: Introductionmentioning

confidence: 99%

Incidence and risk of periodontitis in obstructive sleep apnea: A meta-analysis

Zhang

Zhai

et al. 2022

PLoS ONE

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“…As sleep-disordered breathing is common in people with obesity and could severely impact sleep and BP [ 13 , 14 ], we applied linear regression adjusting for sex and weight status to examine whether the number of oxygen desaturation events per hour (measured by the oxygen desaturation index (ODI); [ 15 ]) is associated with morning BP outcomes in the sleep condition. However, ODI did not significantly predict morning BP in the sleep condition (ankle site: p = 0.877 for systolic BP; p = 0.580 for diastolic BP; p = 0.793 for mean arterial BP; brachial site: p = 0.255 for systolic BP; p = 0.611 for diastolic BP; and p = 0.372 for mean arterial BP).…”

Section: Resultsmentioning

confidence: 99%

Effects of One Night of Forced Wakefulness on Morning Resting Blood Pressure in Humans: The Role of Biological Sex and Weight Status

et al. 2022

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Permanent night shift work is associated with adverse health effects, including elevated blood pressure (BP) and hypertension. Here, we examined the BP response to one night of forced wakefulness in a sitting position in a cohort without night shift work experience. According to a counterbalanced crossover design, 47 young adults with either obesity (N = 22; 10 women) or normal weight (N = 25; 11 women) participated in one night of sleep and one night of forced wakefulness under in-laboratory conditions. Resting ankle and brachial arterial BP were assessed in the morning, i.e., the time of the day when adverse cardiovascular events peak. After forced wakefulness, diastolic and mean arterial BP were ~4 mmHg higher at the ankle site and ~3 mmHg higher at the brachial site than after regular sleep (p < 0.05). The increase in BP following overnight forced wakefulness was more pronounced among men vs. women and more significant for diastolic BP at both sites among participants with normal weight vs. those with obesity. If confirmed in larger cohorts, including 24 h BP monitoring, people with occupations involving night shifts might benefit from regular BP monitoring. Particular attention should be paid to possible sex- and weight-specific effects of night shift work on BP.

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“…We can infer that, after the treatment of any nasal obstruction and the switch to nasal-breathing via the taping of the mouth, the retropalatal space might be widened and therefore improve snoring and the severity of OSA. Since ODI and AHI have a good concordance, a significant reduction of ODI after mouth-taping is also conceivable [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Mouth-Taping in Mouth-Breathers with Mild Obstructive Sleep Apnea: A Preliminary Study

Lee

Cheng

et al. 2022

Healthcare

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Background: Many patients with obstructive sleep apnea (OSA) are mouth-breathers. Mouth-breathing not only narrows the upper airway, consequently worsening the severity of OSA, but also it affects compliance with nasal continuous positive airway pressure (CPAP) treatment. This study aimed to investigate changes in OSA by the use of mouth tape in mouth-breathers with mild OSA. Method: Mouth-breathers with mild OSA who met inclusion criteria and tolerated the sealing of the mouth were enrolled in the study. We used 3M silicone hypoallergenic tape was used to seal the mouths of the participants during sleep. The home sleep test (HST) used in this study was ApneaLink®. Subjects received both a baseline HST and an outcome HST to be used 1 week later while their mouths were taped. The changes between the baseline and the outcome HSTs were compared, and the factors that influenced the differences in the sleep-test parameters after the shift of the breathing route were analyzed. A “responder” was defined as a patient who experienced a reduction from the baseline snoring index of at least 50% under mouth-taping in the HST; otherwise, patients were considered as having a poor response. Results: A total of 20 patients with mild OSA were included. Following the taping of the mouth, a good response was found in 13 patients (65%). The median apnea/hypopnea index (AHI) decreased significantly, from 8.3 to 4.7 event/h (by 47%, p = 0.0002), especially in supine AHI (9.4 vs. 5.5 event/h, p = 0.0001). The median snoring index (SI) was also improved (by 47%, 303.8 vs. 121.1 event/h, p = 0.0002). Despite no significant difference in the mean saturation, improvements in the oxygen desaturation index (8.7 vs. 5.8, p = 0.0003) and the lowest saturation (82.5% vs. 87%, p = 0.049) were noted. The change in AHI was associated with baseline AHI (r = −0.52, p = 0.02), oxygen desaturation index (ODI) (r = −0.54, p = 0.01), and SI (r = −0.47, p = 0.04). The change in SI was strongly associated with baseline SI (r = −0.77, p = 0.001). Conclusions: Mouth-taping during sleep improved snoring and the severity of sleep apnea in mouth-breathers with mild OSA, with AHI and SI being reduced by about half. The higher the level of baseline AHI and SI, the greater the improvement was shown after mouth-taping. Mouth-taping could be an alternative treatment in patients with mild OSA before turning to CPAP therapy or surgical intervention.

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Oxygen desaturation index as alternative parameter in screening patients with severe obstructive sleep apnea

Cited by 21 publications

References 13 publications

Incidence and risk of periodontitis in obstructive sleep apnea: A meta-analysis

Incidence and risk of periodontitis in obstructive sleep apnea: A meta-analysis

Effects of One Night of Forced Wakefulness on Morning Resting Blood Pressure in Humans: The Role of Biological Sex and Weight Status

The Impact of Mouth-Taping in Mouth-Breathers with Mild Obstructive Sleep Apnea: A Preliminary Study

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