Abstract:Sre1, the fission yeast Sterol Regulatory Element Binding Protein (SREBP), is a principal regulator of low oxygen gene expression whose activation is required for low oxygen growth. Oxygen regulates the activity of Sre1 by two independent mechanisms:
Sre1 proteolysis is stimulated by inhibition of oxygen‐dependent sterol synthesis; and
oxygen accelerates the degradation of nuclear Sre1.
Here, we report the identification of 4‐methyl sterols as a signal for activation of Sre1 proteolysis. These sterols accumul… Show more
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