Oxygen consumption predicts outcome in porcine partial liver grafts

Shiba, Hiroaki; Zhu, Xiaocheng; Arakawa, Yusuke; Irefin, Samuel A.; Wang, Bin; Trenti, Loris; Fung, John J.; Kelly, D. G.

doi:10.1016/j.jss.2014.02.013

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…In a porcine partial liver graft model, high intraoperative oxygen consumption was found to be related to lower hepatic artery flow, graft failure, and poor survival . In addition, increases in liver graft oxygen consumption and portal vein pressure are associated with greater portal vein resistance during adult liver transplantation .…”

Section: Discussionmentioning

confidence: 94%

Near‐infrared spectroscopy might be a useful tool for predicting the risk of vascular complications after pediatric liver transplants: Two case reports

Shiba

Satoh

Taira

et al. 2017

Pediatric Transplantation

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In patients that have undergone liver transplants, a postoperative reduction in the blood flow of the liver graft represents a critical complication. We recently encountered an interesting phenomenon; that is, we found that the rSO level of the liver graft, as measured by NIRS, drops in patients that subsequently require an emergency liver biopsy. An 8-month-old female and an 8-month-old male underwent living donor liver transplants for biliary atresia. In both cases, a reduction in rSO was detected before an emergency liver biopsy was required. As a result of biopsy examinations, both patients were diagnosed with acute graft rejection. NIRS might be useful for graft management during the postoperative period in pediatric patients that undergo liver transplantation. After a liver transplant, a reduction in the rSO of the graft might be indicative of the onset of vascular complications.

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Section: Discussionmentioning

confidence: 94%

Near‐infrared spectroscopy might be a useful tool for predicting the risk of vascular complications after pediatric liver transplants: Two case reports

Shiba

Satoh

Taira

et al. 2017

Pediatric Transplantation

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“…Persistent organ failure is major determinant of mortality in AP (Turkvatan et al 2014). Liver tissue is susceptible to oxidative stress because of its high oxygen consumption and modest antioxidant defenses (Shiba et al 2014). Marked microcirculatory disorders and degenerative changes in the liver reflect the nature of the pathological process in AP (Nepomnyashchikh et al 2013).…”

Section: Introductionmentioning

confidence: 99%

The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response

et al. 2015

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Acute pancreatitis (AP) may cause significant persistent multi-organ dysfunction. Carvacrol (CAR) possesses a variety of biological and pharmacological properties. The aim of the present study was to analyze the hepatic protection of CAR on AP induced by cerulein and to explore the underlying mechanism using in vivo studies. The rats were randomized into groups to receive (1) no therapy; (2) 50 lg/kg cerulein at 1-h intervals by four intraperitoneal injection (i.p.); (3) 50, 100 and 200 mg/kg CAR by one i.p.; and (4) cerulein ? CAR after 2 h of cerulein injection. 12 h later, serum was provided to assess the blood AST, ALT and LDH values. Also, liver tissues were obtained for histological and biochemical measurements. Liver oxidative stress markers were evaluated by changes in the amount of lipid peroxides measured as MDA and changes in tissue antioxidant enzyme levels, SOD, CAT and GSHPx. Histopathological examination was performed using scoring systems. Oxidative damage to DNA was quantitated in studied tissues of experimental animals by measuring the increase in 8-hydroxydeoxyguanosine (8-OHdG) formations. We found that the increasing doses of CAR decreased pancreatitisinduced MDA and 8-OH-dG levels. Moreover, the liver SOD, CAT and GSH-Px activities in the AP ? CAR group were higher than that of the rats in the AP group. In the treatment groups, AST, ALT and LDH were reduced. Besides, necrosis, coagulation and inflammation in the liver were alleviated (p \ 0.05). We suggest that CAR could be a safe and potent new drug candidate for treating AP through its antioxidative mechanism of action for the treatment of a wide range of disorders related to hepatic dysfunction.

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“…This measurement might not directly reflect local liver VO 2 [20]. Actually, a higher VO 2 after reperfusion in recipients of cadaveric whole liver grafts was associated with a poorer prognosis [20].…”

Section: (38%) 2 (11%)mentioning

confidence: 98%

Intraoperative Oxygen Consumption During Liver Transplantation

Shibata

Matsusaki

Kaku

et al. 2015

Transplantation Proceedings

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Background. The aim of this study was to investigate the changes in oxygen consumption during liver transplantation and to examine the relationship between intraoperatively elevated systemic oxygen consumption and postoperative liver function. Methods. This study was performed in 33 adult patients undergoing liver transplantation between September 2011 and March 2014. We measured intraoperative oxygen consumption through the use of indirect calorimetry, preoperative and intraoperative data, liver function tests, and postoperative complications and outcomes. Results. The mean age of patients was 52 AE 9.7 years; 14 (42%) of them were women. Average Model for End-Stage Liver Disease scores were 20 AE 8.9. Oxygen consumption significantly increased after reperfusion from 172 AE 30 mL/min during the anhepatic phase to 209 AE 30 mL/min (P < .0001). We divided patients into 2 groups according to the increase in oxygen consumption after reperfusion (oxygen consumption after reperfusion minus anhepatic phase oxygen consumption: 40 mL/min increase as cutoff). The higher consumption group had a longer cold ischemia time and higher postoperative aspartate aminotransferase and alanine aminotransferase levels as compared with the lower oxygen consumption group. There were no statistically significant differences in major postoperative complications, but the higher oxygen consumption group tended to have shorter hospital stays than the lower consumption group (58 versus 95 days). Conclusions. We have demonstrated that oxygen consumption significantly increased after reperfusion. Furthermore, this increased oxygen consumption was associated with a longer cold ischemia time and shorter hospital stays.

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Oxygen consumption predicts outcome in porcine partial liver grafts

Cited by 5 publications

References 17 publications

Near‐infrared spectroscopy might be a useful tool for predicting the risk of vascular complications after pediatric liver transplants: Two case reports

Near‐infrared spectroscopy might be a useful tool for predicting the risk of vascular complications after pediatric liver transplants: Two case reports

The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response

Intraoperative Oxygen Consumption During Liver Transplantation

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