Oxygen Concentration’s Effects on Respiratory Mechanics During Recruitment Manoeuvre

Salihoğlu, Ece; Salihoğlu, Ziya

doi:10.1007/s10439-019-02338-6

Cited by 5 publications

(2 citation statements)

References 1 publication

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“…Especially for needle-free injectors which deliver liquid drugs through the skin using high-speed liquid jets, the possible damage and delivery efficiency are greatly influenced by the interaction between the liquid jet and the body tissue. The needle-free injectors have undergone rapid development due to the demand for minimally invasive systems which can reduce the risk of accidents and trypanophobia (needle phobia) caused by injection via standard hypodermic needles (penetration depth: 5–8 mm) 11 – 20 . Although some needle-free injectors have been released to the market, a previous study pointed out that the pain induced by these injectors is significantly greater than that by the conventional needle injection, while the efficacy is less 21 .…”

Section: Introductionmentioning

confidence: 99%

“…Although some needle-free injectors have been released to the market, a previous study pointed out that the pain induced by these injectors is significantly greater than that by the conventional needle injection, while the efficacy is less 21 . Most of the existing needle-free injectors generate non-focused liquid jets, the tip of which has a diameter larger than the nozzle and spreads out as the jet travels 11 , 12 . This causes a wide area of the skin to be exposed to the liquid jet during the injection, causing severe damage to the skin, and hence pain to the patients 14 .…”

Section: Introductionmentioning

confidence: 99%

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Dynamic mechanical interaction between injection liquid and human tissue simulant induced by needle-free injection of a highly focused microjet

Miyazaki

Usawa

Kawai

et al. 2021

Sci Rep

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This study investigated the fluid–tissue interaction of needle-free injection by evaluating the dynamics of the cavity induced in body-tissue simulant and the resulting unsteady mechanical stress field. Temporal evolution of cavity shape, stress intensity field, and stress vector field during the injection of a conventional injection needle, a proposed highly focused microjet (tip diameter much smaller than capillary nozzle), and a typical non-focused microjet in gelatin were measured using a state-of-the-art high-speed polarization camera, at a frame rate up to 25,000 f.p.s. During the needle injection performed by an experienced nurse, high stress intensity lasted for an order of seconds (from beginning of needle penetration until end of withdrawal), which is much longer than the order of milliseconds during needle-free injections, causing more damage to the body tissue. The cavity induced by focused microjet resembled a funnel which had a narrow tip that penetrated deep into tissue simulant, exerting shear stress in low intensity which diffused through shear stress wave. Whereas the cavity induced by non-focused microjet rebounded elastically (quickly expanded into a sphere and shrank into a small cavity which remained), exerting compressive stress on tissue simulant in high stress intensity. By comparing the distribution of stress intensity, tip shape of the focused microjet contributed to a better performance than non-focused microjet with its ability to penetrate deep while only inducing stress at lower intensity. Dynamic mechanical interaction revealed in this research uncovered the importance of the jet shape for the development of minimally invasive medical devices.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dynamic mechanical interaction between injection liquid and human tissue simulant induced by needle-free injection of a highly focused microjet

Miyazaki

Usawa

Kawai

et al. 2021

Sci Rep

View full text Add to dashboard Cite

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An Experimental Platform Generating Simulated Blunt Impacts to the Head Due to Rearward Falls

Neice

Lurski

Bartsch³

et al. 2021

Ann Biomed Eng

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Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports

Ghajari

Mao

et al. 2022

Ann Biomed Eng

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Head acceleration measurement sensors are now widely deployed in the field to monitor head kinematic exposure in contact sports. The wealth of impact kinematics data provides valuable, yet challenging, opportunities to study the biomechanical basis of mild traumatic brain injury (mTBI) and subconcussive kinematic exposure. Head impact kinematics are translated into brain mechanical responses through physics-based computational simulations using validated brain models to study the mechanisms of injury. First, this article reviews representative legacy and contemporary brain biomechanical models primarily used for blunt impact simulation. Then, it summarizes perspectives regarding the development and validation of these models, and discusses how simulation results can be interpreted to facilitate injury risk assessment and head acceleration exposure monitoring in the context of contact sports. Recommendations and consensus statements are presented on the use of validated brain models in conjunction with kinematic sensor data to understand the biomechanics of mTBI and subconcussion. Mainly, there is general consensus that validated brain models have strong potential to improve injury prediction and interpretation of subconcussive kinematic exposure over global head kinematics alone. Nevertheless, a major roadblock to this capability is the lack of sufficient data encompassing different sports, sex, age and other factors. The authors recommend further integration of sensor data and simulations with modern data science techniques to generate large datasets of exposures and predicted brain responses along with associated clinical findings. These efforts are anticipated to help better understand the biomechanical basis of mTBI and improve the effectiveness in monitoring kinematic exposure in contact sports for risk and injury mitigation purposes.

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Oxygen Concentration’s Effects on Respiratory Mechanics During Recruitment Manoeuvre

Cited by 5 publications

References 1 publication

Dynamic mechanical interaction between injection liquid and human tissue simulant induced by needle-free injection of a highly focused microjet

Dynamic mechanical interaction between injection liquid and human tissue simulant induced by needle-free injection of a highly focused microjet

An Experimental Platform Generating Simulated Blunt Impacts to the Head Due to Rearward Falls

Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports

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