Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours

McEwan, Conor; Owen, Joshua; Stride, Eleanor; Fowley, Colin; Nesbitt, Heather; Cochrane, David E.; Coussios, Constantin; Borden, Mark A.; Nomikou, Nikolitsa; McHale, Anthony P.; Callan, John F.

doi:10.1016/j.pdpdt.2015.07.019

Cited by 35 publications

(54 citation statements)

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“…In different studies [96,97], a lipid monolayer characterized by hydrophobic tails and hydrophilic head groups, was used to stabilize the microbubbles in the physiological environment. The lipid layer also permitted the release of the hydrophobic payload in the diseased tissue by exploiting the fragmentation of the monolayer when the internal microbubble is exposed to ultrasound irradiation (Fig.…”

Section: Nps Used In the Sonodynamic Therapymentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

327

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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Section: Nps Used In the Sonodynamic Therapymentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

327

247

View full text Add to dashboard Cite

show abstract

“…Recently, McEwan et al [244] have demonstrated the effectiveness of sonodynamic therapy (SDT) for the treatment of PDAC in a preclinical model. Basically, SDT involves the localised activation of an otherwise non-toxic sensitiser by a stimulus generating cytotoxic ROS [244].…”

Section: Emerging Chemotherapeutic Treatmentsmentioning

confidence: 99%

“…Basically, SDT involves the localised activation of an otherwise non-toxic sensitiser by a stimulus generating cytotoxic ROS [244]. Given the fact that PDAC is highly hypoxic, this negatively impacts the efficacy of the SDT approach.…”

Section: Emerging Chemotherapeutic Treatmentsmentioning

confidence: 99%

“…Given the fact that PDAC is highly hypoxic, this negatively impacts the efficacy of the SDT approach. Thus, McEwan et al [244] aimed to incorporate oxygen in the core of the microbubbles (MB) to enhance the amount of ROS generated in the tumour microenvironment, as oxygen is a substrate for ROS production in SDT. Encouragingly, an injection of ultrasound-responsive microbubbles (MB), filled with gaseous oxygen provided a significant SDT-mediated reduction in tumours.…”

Section: Emerging Chemotherapeutic Treatmentsmentioning

confidence: 99%

“…Encouragingly, an injection of ultrasound-responsive microbubbles (MB), filled with gaseous oxygen provided a significant SDT-mediated reduction in tumours. Later, McEwan et al [244] has described the preparation of an oxygen-loaded microbubble (O2MB) platform for the highly targeted treatment of PDAC using both sonodynamic therapy (SDT) and antimetabolite therapy (5-FU). The aim of this study was to increase efficacy of anti-metabolite therapy by sensitising microenvironment and also reduce chemotherapy-associated side effects [245].…”

Section: Emerging Chemotherapeutic Treatmentsmentioning

confidence: 99%

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Scientific rationale for integrative and personalised strategies for pancreatic ductal adenocarcinoma management

Korhan¹,

Verkerk²,

Critchley³

2017

Integr Mol Med

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Pancreatic ductal adenocarcinoma (PDAC) arises from epithelia of pancreas. Despite its low incidence, it is the most lethal cancer type. Although the poor outcome is largely secondary to the high proportion of patients who are diagnosed with advanced disease, the prognosis of PDAC is also influenced by the inherent biological aggressiveness and the high metastatic potential of this malignancy. Treatment options remain limited with little progress over the last decades. Some improvements in surgical outcome occur in patients who also receive chemotherapy and/or radiotherapy, however, the impact on long-term survival has been minimal owing to the intense resistance of PDAC to all extent treatments regimen. Hence, there is an urgent need to 1) gain better understanding of the biology of PDAC; 2) to develop early detection and prevention programs; 3) to identify new therapeutic strategies to improve quality of life and survivorship. In this review, first, we will summarise the state of knowledge of PDAC pathogenesis with a particular the focus on the molecular characteristics causing therapeutic resistance. Then, we will briefly review current and emerging approaches in the PDAC care. Lastly, we will highlight the integrative approaches in the light of new experimental and clinical research conducted with the aim of moving towards personalised therapy in patients with PDAC.

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Sonodynamic Therapy: Advances and Challenges in Clinical Translation

Lafond

Yoshizawa

Umemura

2018

J of Ultrasound Medicine

114

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Sonodynamic therapy (SDT) consists of the synergetic interaction between ultrasound and a chemical agent. In SDT, the cytotoxicity is triggered by ultrasonic stimuli, notably through cavitation. The unique features of SDT are relevant in the clinical context more than ever: the need for efficacy, accuracy, and safety while being noninvasive and preserving the patient's quality of life. However, despite the promising results of this technique, only a few clinical reports describe the use of SDT. The objective of this article is to provide an extensive overview of the clinical and preclinical research conducted in vivo on SDT, to identify the limitations, and to detail the developed strategies to overcome them.

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Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours

Cited by 35 publications

References 0 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Scientific rationale for integrative and personalised strategies for pancreatic ductal adenocarcinoma management

Sonodynamic Therapy: Advances and Challenges in Clinical Translation

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