Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases

Liang, Ruijing; Liu, Lanlan; He, Hongqing; Chen, Zhi-Kuan; Han, Zhiqun; Luo, Zhenyu; Wu, Zhihao; Zheng, Mingbin; Ma, Yifan; Cai, Lintao

doi:10.1016/j.biomaterials.2018.05.051

Cited by 255 publications

(203 citation statements)

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“…Similarly, Shi and co‐workers demonstrated that all blood indexes (including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, creatinine, red blood cell count, white blood cell count, hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width, mean corpuscular hemoglobin, mean corpuscular volume, and blood routine levels of hematocrit) and body weight showed no significant differences compared with the control group exposed to hollow mesoporous organosilica‐MnO x NPs via an intravenous administration . A number of other studies also proved the biosecurity of MONs 6b,34,43q,46c,90. All the in vivo toxicity results suggested MONs did not show any evident toxic effects under a certain concentration when injected in mice intravenously.…”

Section: The Chemical Properties Surface Engineering and Toxicity Omentioning

confidence: 89%

“…For example, MnO 2 NSs were designed as a unique support to integrate DOX and cytosine‐phosphate‐guanine (CpG)‐Ag NPs together for TME‐mediated DOX and CpG deliveries . Another case is that core–shell Au@MnO 2 (AM) NPs were produced for FL/PA/MR‐imaging guided O 2 ‐boosted PDT and immunotherapy by Cai group ( Figure a,b) . In this study, MnO 2 shell is very significant to promote PDT via producing oxygen, and subsequently boost antitumor immunity via ICD.…”

Section: Therapeutic Applicationsmentioning

confidence: 90%

Section: Therapeutic Applicationsmentioning

confidence: 99%

“…It is worth mentioning that few research reported that MnO 2 processes glucose oxidase (GOx)‐like activity and is promising for starvation therapy directly . Last but not least, MONs are hopeful to boost immunotherapy by multifarious routes, such as O 2 ‐instructed PDT‐induced immunogenic cell death (ICD), O 2 ‐mediated RT‐guided downregulation of PD‐L1 and hypoxia‐regulated polarization of tumor‐associated macrophages (TAM) . In short, MONs are like universal therapeutic agents for tumor therapy.…”

Section: Introductionmentioning

confidence: 99%

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO2, MnO, Mn2O3, Mn3O4, and MnOx) and their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, the representative progresses of MONs on synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, and therapy are mainly introduced. First, five kinds of primary synthetic methods of MONs are presented, including thermal decomposition method, exfoliation strategy, permanganates reduction method, adsorption–oxidation method, and hydro/solvothermal. Second, the preparations of hollow MONs and MON‐based composite materials are summarized specially. Then, the chemical properties, surface modification, and toxicity of MONs are discussed. Next, the diagnostic applications including imaging and sensing are outlined. Finally, some representative rational designs of MONs in photodynamic therapy, photothermal therapy, chemodynamic therapy, sonodynamic therapy, radiotherapy, magnetic hyperthermia, chemotherapy, gene therapy, starvation therapy, ferroptosis, immunotherapy, and various combination therapy are highlighted.

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Section: The Chemical Properties Surface Engineering and Toxicity Omentioning

confidence: 89%

Section: Therapeutic Applicationsmentioning

confidence: 90%

Section: Therapeutic Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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“…[12][13][14][15][16][17][18][19][20] Nevertheless, the application of these two strategies is restricted due to serious side effects, high cost, and large individual variations. [21][22][23][24] More seriously, some tumor tissues, especially triple-negative breast cancer (TNBC), have relatively low immune response after treatment of checkpoint inhibitors, which is mainly attributed to "cold" immune microenvironment. 4 Hence, exploring novel and powerful methods to achieve the "hot" immune microenvironment and trigger immune response as a prelude for immunotherapy is particularly crucial.…”

Section: Introductionmentioning

confidence: 99%

<p>Combinational phototherapy and hypoxia-activated chemotherapy favoring antitumor immune responses</p>

Sheng

Wang

et al. 2019

IJN

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Background: Tumor metastasis is responsible for most cancer death worldwide, which lacks curative treatment. Purpose: The objective of this study was to eliminate tumor and control the development of tumor metastasis. Methods: Herein, we demonstrated a smart nano-enabled platform, in which 2-[2-[2-chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2h-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propylindolium iodide (IR780) and tirapazamine (TPZ) were co-loaded in poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL) to form versatile nanoparticles (PEG-PCL-IR780-TPZ NPs). Results: The intelligence of the system was reflected in the triggered and controlled engineering. Specially, PEG-PCL not only prolonged the circulation time of IR780 and TPZ but also promoted tumor accumulation of nanodrugs through enhanced permeability and retention (EPR) effect. Moreover, reactive oxygen species (ROS) generated by IR780 armed by an 808 nm laser irradiation evoked a cargo release. Meanwhile, IR780, as a mitochondria-targeting phototherapy agent exacerbated tumor hypoxic microenvironment and activated TPZ for accomplishing hypoxia-activated chemotherapy. Most significantly, IR780 was capable of triggering immunogenic cell death (ICD) during the synergic treatment. ICD biomarkers as a “danger signal” accelerated dendritic cells (DCs) maturation, and subsequently activated toxic T lymphocytes. Conclusion: Eventually, antitumor immune responses stimulated by combinational phototherapy and hypoxia-activated chemotherapy revolutionized the current landscape of cancer treatment, strikingly inhibiting tumor metastasis and providing a promising prospect in the clinical application.

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Covalent Organic Framework‐Supported Molecularly Dispersed Near‐Infrared Dyes Boost Immunogenic Phototherapy against Tumors

Gan

Tong

Zhang

et al. 2019

Adv Funct Materials

115

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Photodynamic therapy (PDT) mediated by near‐infrared (NIR) dyes is a promising cancer treatment modality; however, its use is limited by significant challenges, such as hypoxic tumor microenvironments and self‐quenching of photosensitizers. These challenges hamper its utility in inducing immunogenic cell death (ICD) and triggering potent systemic antitumor immune responses. This study demonstrates that molecular dispersion of NIR dyes in nanocarriers can significantly enhance their ability to produce reactive oxygen species and potentiate synergistic PDT and photothermal therapy against tumors. Specifically, NIR dye indocyanine green (ICG) can be spontaneously adsorbed to covalent organic frameworks (COFs) via π–π conjugations to prevent intermolecular stacking interactions. Then, ICG‐loaded COFs are ultrasonically exfoliated and coated with polydopamine (PDA) to construct a new phototherapeutic agent ICG@COF‐1@PDA with enhanced efficacy. In conjunction with ICG@COF‐1@PDA, a single round of NIR laser irradiation can induce obvious ICD, elicit antitumor immunity in colorectal cancer, and yield 62.9% inhibition of untreated distant tumors. ICG@COF‐1@PDA also exhibits notable phototherapeutic efficacy against 4T1 murine breast to lung metastasis, a spontaneous metastasis mode for triple‐negative breast cancers (TNBCs). Overall, this study reveals a novel nanodelivery system for molecular dispersion of NIR dyes, which may present new therapeutic opportunities against primary and metastatic tumors.

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Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases

Cited by 255 publications

References 49 publications

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

<p>Combinational phototherapy and hypoxia-activated chemotherapy favoring antitumor immune responses</p>

Covalent Organic Framework‐Supported Molecularly Dispersed Near‐Infrared Dyes Boost Immunogenic Phototherapy against Tumors

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