Oxygen as a Regulator of Tissue Perfusion

McCabe, M.; Bourgain, Renaat; Maguire, David

doi:10.1007/978-1-4757-6125-2_40

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Oxygen levels are correlated with regulation of tissue perfusion (McCabe et al, 2003) and tissue respiration (Hogan et al, 1992) and P O2 was supported as a messenger in metabolic control (Platzack and Hicks, 2001). The tissue oxygen concentration is a critical biochemical variable in nuclear gene expression and mitochondrial DNA-encoded complex I gene expression (Meyron-Holtz et al, 2004;Piruat and Lopez-Barneo, 2005).…”

Section: Discussionmentioning

confidence: 99%

Fluctuation of Brain Tissue Oxygen Partial Pressure: A Biochemical Landmark in the Arctic Ground Squirrel's Spontaneous Arousal

R.¹

2011

American Journal of Biochemistry and Biotechnology

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Hibernation in the Arctic Ground Squirrel (AGS) is a regulated, adaptive response to arctic environmental conditions. Problem statement: Regional brain Blood Flow (rCBF) has been observed to increase dramatically during arousal in hibernators. However, the real time dynamic change in P t O 2 during arousal has not been studied, we hypothesized that P t O 2 is Interdependent of T brain and a key component in the arousal process. Approach: Simultaneous in vivo measurements of P t O 2 and brain temperature (T brain ) in conjunction with oxygen consumption (V 02 ) were conducted in the striatum of non-sedated, non-anesthetized Arctic ground squirrels during spontaneous arousal from hibernation. Results: A dramatic fluctuation of brain tissue oxygen partial pressure (P t O 2 ) is associated with the complex phenomena of spontaneous arousal. In this study, we observed that: (1) a P t O 2 elevation precedes changes in T brain and V 02 ; (2) P t O 2 changes do not correlate with changes in V 02 during arousal and (3), endogenous O 2 shift from O 2 enriched blood to brain in hibernating AGS induces an arousal with the pharmaceutical chemical, efaproxiral (RSR-13). Conclusion: The four turning points of P t O 2 appearing at different T brain during arousal suggest that changes in P t O 2 are T brain interdependent and support the concept that arousal from hibernation is complex process invoking different feedbacks.

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Section: Discussionmentioning

confidence: 99%

Fluctuation of Brain Tissue Oxygen Partial Pressure: A Biochemical Landmark in the Arctic Ground Squirrel's Spontaneous Arousal

R.¹

2011

American Journal of Biochemistry and Biotechnology

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ISOTT from the Beginning: A Tribute to Our Deceased Members (Icons)

Bruley¹,

Thiessen

2016

Advances in Experimental Medicine and Biology

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ISOTT was founded by Drs. Duane F. Bruley and Haim I. Bicher in the state of South Carolina, USA in 1973. The symposium was jointly held at Clemson University (Clemson, SC, USA) and the Medical College of South Carolina (Charleston, SC, USA), which are geographically located 260 miles apart. This venue resulted from Dr. Bruley's (Clemson University) wish to have a meeting on Oxygen Transport to Tissue and with it to honor the research collaboration between the two universities and Dr. Melvin H. Knisely's accomplishments on studies regarding "blood sludging" in the microcirculation. Because of the unexpected large response to the symposium, Drs. Bruley and Bicher decided to found an international society at this meeting (ISOTT). The purpose of this paper is to summarize the formalization of ISOTT and to honor important contributors to the society who have since passed away. The authors did their best to include a brief overview of our past icons who have excelled in leadership as well as science/engineering, and apologize if someone has been mistakenly left out or if data is inaccurate or incomplete.

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Oxygen as a Regulator of Tissue Perfusion

Cited by 2 publications

References 10 publications

Fluctuation of Brain Tissue Oxygen Partial Pressure: A Biochemical Landmark in the Arctic Ground Squirrel's Spontaneous Arousal

Fluctuation of Brain Tissue Oxygen Partial Pressure: A Biochemical Landmark in the Arctic Ground Squirrel's Spontaneous Arousal

ISOTT from the Beginning: A Tribute to Our Deceased Members (Icons)

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