Oxygen and reactive oxygen species in cartilage degradation: friends or foes?

Henrotin, Yves; Kurz, Bodo; Aigner, Thomas

doi:10.1016/j.joca.2005.04.002

Cited by 416 publications

(336 citation statements)

References 117 publications

(71 reference statements)

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“…16 Curcuminoids have also been reported to exhibit antioxidant properties. 17 They have been demonstrated to scavenge reactive oxygen and nitrogen species [18][19][20] and inhibit the activity of IL-1b-induced superoxide dismutase. 21 In vitro studies have also shown that curcuminoids inhibit IL-1b-induced glycosaminoglycan (GAG) release from animal and human OA cartilage explants.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta‐analysis of randomized clinical trials

et al. 2017

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Aim: To critically appraise and evaluate the evidence for effectiveness of curcuminoids in the treatment of osteoarthritis (OA) in adults. Methods:We conducted electronic searches in Medline, Embase, AMED, Cinahl and the Cochrane library. We included randomized controlled trials (RCTs) that investigated the effectiveness of orally-administered curcuminoids in OA in adults, and assessed risk of bias using the Cochrane risk of bias criteria. We used a random-effect model for meta-analysis. Results:We included seven studies with a total of 797 participants with primarily knee OA. All studies were conducted in Asia. The overall risk of bias was moderate. Compared with placebo, curcuminoids significantly reduced knee pain (visual analogue scale): (standardized mean difference: À3.45; 95% CI: À5.52 to À1.38; I 2 = 95% P = 0.001), and improved quality of life (Lequesne pain-function index): (mean difference: À2.69; 95% CI: À3.48 to À1.90; I 2 = 0% P < 0.00001). There were significantly fewer effects on pain relief, knee stiffness and physical function with curcuminoids compared with ibuprofen. Significant improvements in Western Ontario and McMaster Universities Arthritis Index total scores, with significant reductions in the use of rescue medication were also observed with curcuminoids. No serious adverse events were reported.Conclusions: Curcuminoids may have some beneficial effects on knee pain and quality of life in patients with knee OA. However, they are less effective at relieving pain compared with ibuprofen. Curcuminoids appear safe on the short-term, and may reduce the need for rescue medication. Published RCTs vary in reporting quality, are characterized by small sample sizes, and have all been conducted in Asia. Further clinical trials are therefore warranted.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta‐analysis of randomized clinical trials

et al. 2017

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“…Several studies have demonstrated that oxidative damage, due to overproduced rOS from superoxide, may be involved in the pathogenesis of Oa (8,9). in this regard, it has been reported that oxidative stress leads to structural and functional changes in chondrocytes and extracellular matrix, when rOS production exceeds the anti-oxidant capacities (3,10,11). a number of animal models have been developed to investigate the pathology of Oa.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of oxidative stress on articular cartilage in spontaneously osteoarthritic STR/OrtCrlj mice by measuring the biomarkers for oxidative stress and type II collagen degradation/synthesis

Watari

Naïto

Sakamoto

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. to investigate the involvement of oxidative stress in the pathogenesis of osteoarthritis (Oa), we evaluated the relationship between oxidative stress and articular cartilage degradation by measuring the serum levels of malondialdehyde (mda, an oxidative stress marker), ctx-ii (a type ii collagen degradation marker) and cpii (a type ii collagen synthesis marker) in obese and hyperlipidemic Str/Ort (Str) and control cBa mice. Seven-week-old osteoarthritic Str male mice (n=10) and control cBa male mice (n=10) were fed standard laboratory food ad libitum. at 35 weeks of age, the mice were sacrificed, and the serum levels of mda, ctx-ii and cpii were determined. Furthermore, histopathological changes were evaluated in the knee joints. most of the Str mice spontaneously developed Oa (18 of the 20 knees). By contrast, the cBa mice developed Oa in only 4 of the 20 knees. importantly, the serum levels of mda, ctx-ii and cpii were elevated to a greater extent in the Str mice compared to levels in the cBa mice. notably, the level of mda was correlated with that of ctx-ii, but not of cpii. Moreover, the MDA levels were significantly correlated with the serum lipid (total cholesterol and triglyceride) levels as well as body weight. together these observations suggest that oxidative stress is likely involved in the degradation of type ii collagen in articular cartilage, thereby possibly contributing to the development of Oa in obese and hyperlipidemic Str mice.

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“…Oxidative stress can also disturbance in the antioxidant defenses mechanism against the level of ROS, which results in cellular damage and disruption of redox homeostasis leading to chondrocyte senescent by causing destruction of proteins, lipids, and DNA directly (Henrotin et al 2005). Increase in ROS level is related to aging process and plays an important role in the progression of OA.…”

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Biological Markers Associated Osteoarthritis

Inchai¹,

Mahakkanukrauh²

2017

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ABSTRAK ABSTRACTOsteoarthritis is the most common degenerative joint disease that develops in the elderly. The worldwide prevalence continues to rise, leading to pain and disability in older ages. Osteoarthritis can be diagnosed by using plain film X-ray combined with clinical appearance and structural features. The imbalance between cartilage synthesis and degradation has been explained in the development of osteoarthritis, which is associated with chondrocyte death. There are many cytokines and biological markers related to the disease. The present review provides a background and discusses the known biological markers that are related to developing osteoarthritis. These include advance glycation end products, glutathione and glycosaminoglycans.

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Oxygen and reactive oxygen species in cartilage degradation: friends or foes?

Cited by 416 publications

References 117 publications

Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta‐analysis of randomized clinical trials

Effectiveness of curcuminoids in the treatment of knee osteoarthritis: a systematic review and meta‐analysis of randomized clinical trials

Evaluation of the effect of oxidative stress on articular cartilage in spontaneously osteoarthritic STR/OrtCrlj mice by measuring the biomarkers for oxidative stress and type II collagen degradation/synthesis

Biological Markers Associated Osteoarthritis

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