Oxygen and indocyanine green loaded phase-transition nanoparticle-mediated photo-sonodynamic cytotoxic effects on rheumatoid arthritis fibroblast-like synoviocytes

Tang, Qin; Cui, Jianyu; Tian, Zhonghua; Sun, Jiao; Wang, Zhigang; Chang, Shufang; Zhu, Shirley

doi:10.2147/ijn.s120902

Cited by 40 publications

(39 citation statements)

References 41 publications

(52 reference statements)

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“…38 Indeed, previous studies have explored that, compared with the monotherapy (PDT or SDT), PSDT decreased the sensitizer dosage and light/US energy that can further reduce the side effects. 7,[39][40][41][42][43] Moreover, our results demonstrated that both laser and US were essential elements for evaporation and destruction of TOI_HNPs. Thus, we did not test the therapeutic efficiency of TOI_HNPs + PDT and TOI_HNPs + SDT.…”

Section: Therapeutic Effectsupporting

confidence: 51%

“…Drug release occurred in an initial "burst" release phase and subsequent slow release. 7 In detail, the cumulative ICG release of TOI_LNPs in PBS and BSA reached to 66.68% and 80.59%, respectively. Correspondingly, the release of OI_PNPs was 30.51% in PBS and 34.97% in BSA.…”

Section: Results and Discussion Preparation And Characterization Of Npsmentioning

confidence: 93%

“…OI_PNPs (PLGA NPs-encapsulated ICG and PFP-carrying oxygen) were prepared by replacing the lipid film with PVA aqueous solution (5 mL, 5% w/v), since it is the most common emulsion stabilizer used in the pharmaceutical field to prepare micro and nanosystems. 7,25 No ICG-or PFP-carrying oxygen is added into TO_HNPs and TI_HNPs, respectively. Other processes are similar to the above steps.…”

Section: Formulation Of Npsmentioning

confidence: 99%

“…[3][4][5] In the past few decades, intensive researches have been made in nanomedicine and several nanoplatforms have been approved for clinical trials. 3,6 Nanoplatform has the following characteristics: 1) optimal size: nanosized particles achieved passive targeting through enhanced permeability and retention effect; 7 2) drug loading: nanocarriers can encapsulate some molecules such as hydrophobic drugs, contrast agents, and siRNA for the high surface-to-volume ratio; 3 3) easily modifiable: nanoparticles (NPs) are modified by specific ligands for biocompatibility or active targeting; 8 and 4) favorable physicochemical characteristics: imaging and treatment are carried out using the unique properties of the nanocarrier itself (such as semiconductor quantum dots) 9 or encapsulating molecules (such as photosensitizers). 10 Hence, multifunctional NPs provide an opportunity for precise imaging and targeted therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Indocyanine green (ICG) has been proved to be an ideal sensitizer for photodynamic therapy (PDT) or sonodynamic therapy (SDT) by production of ROS. 7,8,15 Perfluorocarbons (PFCs) are great oxygen carriers that improve the oxygen concentration at the target site. 16 Specially designed PFC NPs can convert into microbubbles under the action of laser irradiation by incorporating optical absorbing materials into nanocarriers (termed as optical droplet vaporization [ODV]).…”

Section: Introductionmentioning

confidence: 99%

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<p>A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells</p>

Chen¹,

Sun²,

Chen³

et al. 2019

IJN

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PurposeNanomedicine has emerged as a novel therapeutic modality for cancer treatment and diagnosis. Lipid–polymer hybrid nanoparticles (LPHNPs) are core–shell nanoparticle (NP) structures comprising polymer cores and lipid shells, which exhibit complementary characteristics of both polymeric NPs and liposomes. However, it is difficult to wrap perfluoropentane (PFP) into core–shell NPs in the existing preparation process, which limits its application in the integration of diagnosis and treatment.MethodsThe folate-targeted LPHNPs-loaded indocyanine green/PFP-carrying oxygen (TOI_HNPs) using a combination of two-step method and solution evaporation technique for the first time. The essential properties and dual-mode imaging characteristics of developed NPs were determined. The cellular uptake of TOI_HNPs was detected by confocal microscopy and flow cytometry. The SKOV3 cell viability and apoptosis rate were evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and flow cytometry. The ROS was demonstrated by fluorescence microplate reader and the expression of hypoxia-inducible factor 1-alpha (HIF-1α) and IL-6 was detected by Western blot.ResultsTOI_HNPs showed spherical morphology with particle size about (166.83±5.54) nm and zeta potential at −(30.57±1.36) mV. It exhibited better stability than lipid NPs and higher encapsulation efficiency as well as active targeting ability than poly (lactic-co-glycolic acid) (PLGA) NPs. In addition, the novel NPs could also act as the contrast agents for ultrasound and photoacoustic imaging, providing precision guidance and monitoring. Furthermore, TOI_HNPs-mediated photo–sonodynamic therapy (PSDT) caused more serious cell damage and more obvious cell apoptosis, compared with other groups. The PSDT mediated by TOI_HNPs induced generation of intracellular ROS and downregulated the expression of HIF-1α and IL-6 in SKOV3 cells.ConclusionThis kind of multifunctional-targeted nanoagent may provide an ideal strategy for combination of high therapeutic efficacy and dual-mode imaging guidance.

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Section: Therapeutic Effectsupporting

confidence: 51%

Section: Results and Discussion Preparation And Characterization Of Npsmentioning

confidence: 93%

Section: Formulation Of Npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

<p>A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells</p>

Chen¹,

Sun²,

Chen³

et al. 2019

IJN

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Intelligent Sonocatalytic Nanoagents for Energy Conversion‐Based Therapies

Feng,

Xiang,

Huang

et al. 2023

Adv Funct Materials

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Sonodynamic therapy (SDT) utilizes ultrasound‐irradiating sonosensitizers to convert ultrasonic vibrations into chemical energy and produce reactive oxygen species (ROS) that cause cell apoptosis or necrosis. SDT demonstrates significant potential in the treatment of deep tumors without normal tissue damage. Rapid advances in the efficacy of SDT have enabled the rational design and construction of novel intelligent sonocatalytic nanoagents (SCNs) with various functions for versatile biomedical applications. Herein, the most recent critical advancements in intelligent SCNs for energy conversion‐based therapies are discussed. Typical SCNs including organic molecules, organic micro‐/nanoparticles, inorganic micro‐/nanoparticles, organic/inorganic hybrids, and piezoelectric materials are introduced and summarized in detail. Furthermore, these intelligent SCNs are designed for different energy conversion‐based therapies such as SDT, SDT‐assisted chemotherapy, SDT‐assisted photodynamic therapy, SDT‐assisted photothermal therapy, SDT‐assisted gas therapy, SDT‐assisted sonoporation from the cell membrane to the blood brain barrier, and high‐intensity focused ultrasound‐based sonothermal therapy. It is believed that this review will provide an overview of the application of intelligent SCNs in sonodynamic therapies to better understand the limitations and challenges of these SCNs and further promote their advancements for a broad range of biomedical applications.

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

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Oxygen and indocyanine green loaded phase-transition nanoparticle-mediated photo-sonodynamic cytotoxic effects on rheumatoid arthritis fibroblast-like synoviocytes

Cited by 40 publications

References 41 publications

<p>A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells</p>

<p>A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells</p>

Intelligent Sonocatalytic Nanoagents for Energy Conversion‐Based Therapies

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

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