Oxygen and hydrogen peroxide self-supplying magnetic nanoenzymes for cancer therapy through magneto-mechanical force, force-induced reactive oxygen species, chemodynamic effects, and cytotoxicity of Ca2+ ions

Liu, Jie; Yang, Wenxuan; Huang, Yuqiao; Li, Ji; Zhu, Chunjiao; Pu, Guangjin; Wang, Bo; Gui, Xin; Chu, Maoquan

doi:10.1007/s12274-022-5303-5

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…Although substantial research efforts have developed various magnetism‐responsive nanomaterials to perturb the organelles [ 16 , 35 ] to trigger cancer cell death, the mechanism of the cell death was mainly focused on the apoptosis. [ 36 ] The T7‐MNTs as the magneto‐mechanical inducer offered an insight of magneto‐mechanical regulation to trigger the outbreak of endogenous labile iron pool for the long‐acting and selective ferroptosis in cancer therapy.…”

Section: Resultsmentioning

confidence: 99%

A Lysosome‐Targeted Magnetic Nanotorquer Mechanically Triggers Ferroptosis for Breast Cancer Treatment

Wei,

Li,

Chen

et al. 2023

Advanced Science

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Targeting ferroptosis has attracted exponential attention to eradicate cancer cells with high iron‐dependent growth. Increasing the level of intracellular labile iron pool via small molecules and iron‐containing nanomaterials is an effective approach to induce ferroptosis but often faces insufficient efficacy due to the fast drug metabolism and toxicity issues on normal tissues. Therefore, developing a long‐acting and selective approach to regulate ferroptosis is highly demanded in cancer treatment. Herein, a lysosome‐targeted magnetic nanotorquer (T7‐MNT) is proposed as the mechanical tool to dynamically induce the endogenous Fe2+ pool outbreak for ferroptosis of breast cancer. T7‐MNTs target lysosomes via the transferrin receptor‐mediated endocytosis in breast cancer cells. Under the programmed rotating magnetic field, T7‐MNTs generate torques to trigger endogenous Fe2+ release by disrupting the lysosomal membrane. This magneto‐mechanical manipulation can induce oxidative damage and antioxidant defense imbalance to boost frequency‐ and time‐dependent lipid peroxidization. Importantly, in vivo studies show that T7‐MNTs can efficiently trigger ferroptosis under the magnetic field and play as a long‐acting physical inducer to boost ferrotherapy efficacy in combination with RSL3. It is anticipated that this dynamic targeted strategy can be coupled with current ferroptosis inducers to achieve enhanced efficacy and inspire the design of mechanical‐based ferroptosis inducers for cancer treatment.

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Section: Resultsmentioning

confidence: 99%

A Lysosome‐Targeted Magnetic Nanotorquer Mechanically Triggers Ferroptosis for Breast Cancer Treatment

Wei,

Li,

Chen

et al. 2023

Advanced Science

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7][8][9] Since the peroxidase-like properties of iron oxide were discovered in 2007 by Yan, 10 plenty of nanomaterials have been developed to imitate natural enzymes owing to the advantages of nanomaterials, such as increased and customizable catalytic performance as compared to natural enzymes, low cost, convenient, and massive production, as well as high stability. [11][12][13][14] Different kinds of nanozymes have been developed and their catalysing abilities have been investigated, including noble metal-based nanomaterials, iron oxide, MoOx, nitrogen-doped porous carbon nanospheres. [15][16][17][18] These nanomaterials have been employed to mimic oxidase, [19][20][21] peroxidase (POD), [22][23][24] catalase (CAT), [24][25][26] and superoxide dismutase (SOD) 24,27 to produce cytotoxic reactive oxygen species (ROS) or supplement O 2 by decomposing endogenous H 2 O 2 .…”

Section: Introductionmentioning

confidence: 99%