Oxydative phosphorylierung und vitamin K Mangel

Martius, C.; Nitz-Litzow, D

doi:10.1016/0006-3002(54)90292-9

Cited by 86 publications

(4 citation statements)

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“…Recently there has been much interest in the fact that menadione (2-methyl-3-hydroxy-1,4naphthoquinone) (vitamin K,) can serve as a hydrogen and electron carrier between flavoproteins and cytochrome c (Martius and Nitz-Litzow, 1954;Cormier and Totter, 1954;Mahler et al, 1955). E. coli produces significant amounts of Vitamin K (Almquist et al, 1938) and contains enzymes capable of transferring hydrogen and electrons from both DPNH and TPNH to menadione (Wosilait and Nason, 1954).…”

Section: Resultsmentioning

confidence: 99%

SOME ENZYMATIC ACTIVITIES OF A PARTICULATE FRACTION FROM SONIC LYSATES OF ESCHERICHIA COLI

1956

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Crude lysates of animal, plant, and bacterial cells almost invariably can be shown to contain a particulate fraction from which certain oxidative enzymes can be separated and solubilized only with the greatest difficulty. The particles in this fraction should not be confused with the much more complex and highly organized mitochondria that have been isolated from animal and plant cells. They contain a much smaller, less varied, and more stable aggregate of enzymatic activities

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Section: Resultsmentioning

confidence: 99%

SOME ENZYMATIC ACTIVITIES OF A PARTICULATE FRACTION FROM SONIC LYSATES OF ESCHERICHIA COLI

1956

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“…Numerous efforts have been made in recent years to elucidate the metabolism of vitamin K and to define a biological role for this important substance. For example, there is good experimental evidence to show that vitamin K participates in oxidative phosphorylation in chick liver (12), in oxidative phosphorylation in Mycobacterium phlei (3), and in electron transport in Haemophilus parainfluenzae (15). Yet the generally recognized function of vitamin K is in the synthesis of the blood clotting factors, prothrombin and factors VII, IX, and X, all of which are proteins.…”

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confidence: 99%

Vitamin K Deficiency in Fusiformis nigrescens I. Influence on Whole Cells and Cell Envelope Characteristics

Lev

1968

J Bacteriol

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Vitamin K depletion in the vitamin K-requiring anaerobe Fusiformis nigrescens resulted in the formation of elongated cells. In the presence of vitamin K, inhibition by cyanide and heme depletion did not affect cell morphology. Peptide depletion, as well as inhibition by chloramphenicol, ethionine, or fluorophenylalanine, also resulted in formation of elongated cells. Chemical analysis of cells and envelopes showed that protein, lipid, and deoxyribonucleic acid levels were similar in vitaminsupplemented and depleted cells; however, ribonucleic acid (RNA) levels in depleted cells and envelopes were significantly higher than in K-supplemented cells. Sections of cells of both groups showed minor differences in cell surfaces. The relationship between altered cell envelopes and increased RNA levels in K-deficient bacteria indicated a membrane-mediated effect of vitamin K on RNA and possibly protein synthesis in this microorganism.

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“…Vitamin K occurs in animal tissues at a much lower concentration. It has not so far been isolated from animal tissues, though isotope experiments have recently shown that vitamin K2-20 can be formed in the liver from other K vitamins present in the diet (Martius & Esser, 1958;Martius, 1961). The amount present is too small for chemical or spectroscopic determination but the sensitive bioassay (blood coagulation in chicks) indicates that the richest tissue, liver, contains about 0 01 ,tmole/ g. (dry wt.…”

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confidence: 99%