Oxovanadium(V) and Dioxomolybdenum(VI) Complexes of Amide–Imine Conjugates: Structures, Catalytic and Antitumor Activities

Abstract

Three new amide−imine conjugates, namely [(E)-2-hydroxy-N′-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide] (SALNP), [(E)-N′-(4-(diethylamino)-2-hydroxybenzylidene)-2-hydroxybenzohydrazide] (SALSD), and [(E)-N′-(3-ethoxy-4-hydroxybenzylidene)-2-hydroxybenzohydrazide] (SALVN), derived by reacting 2-hydroxybenzohydrazide (SAL) with three different aldehyde, 2-hydroxynapthaldehyde, 4-()-2-hydroxybenzaldehyde, and 3ethoxy-4-hydroxybenzaldehyde, respectively. Three mononuclear oxovanadium(V) and two μ oxo -bridged dinuclear molybdenum(VI) complexes have been synthesized using SALNP and SALSD. Besides, SALVN is used to prepare oxovanadium(V) and dioxomolybdenum(VI) complexes. All five metal complexes along with three amide−imine conjugates are characterized by single crystal XRD analysis. Some of them have been explored as catalyst for oxidation of alkyl benzene and styrene. Antitumor activities of the metal complexes along with ligands have been studied on Dalton lymphoma (DL) and 2PK3 murine lymphoma cells.

Trinuclear dioxidomolybdenum(vi) complexes derived from benzene-1,3,5-tricarbohydrazide and study of the catalytic activity

“…Oxidative halogenation, a key reaction shown by enzymes vanadium-dependent haloperoxidases (V-HPO), 30,31 is responsible for the halogenation in marine natural products. Dioxidomolybdenum( vi ) complexes 17,18 act as functional models of V-HPO and mimic this reaction extremely well. A reaction mechanism for all three catalytic reactions has been proposed based on experimental, as well as DFT evidences.…”

“…[2][3][4][5][6][7][8][9][10][11] Such cis-[Mo VI O 2 ] complexes with hydrazones have been reported extensively in the literature, and their catalytic potentials have mostly been explored for C-H oxidation reactions of organic substrates in the presence of suitable oxidants such as H 2 O 2 and tert-butylhydroperoxide. [12][13][14][15] Other catalytic reactions include sulfide oxidation, 16,17 oxidative bromination of organic substrates 18 and multicomponent onepot reaction (MCR). 19 In general, three types of dioxidomolybdenum(VI) complexes [Fig.…”

Mo(vi) complexes of amide–imine conjugates for tuning the selectivity of fluorescence recognition of Y(iii) vs. Pb(ii)

“…nitrogenase, aldehyde oxidase, xanthine oxidase, sulphite oxidase, nitrate reductase, and xanthine dehydrogenase. 43 Oxo-molybdenum(VI) complexes have interesting stereochemical and microelectronic properties 44 having therapeutic and catalytic applications, possibly due to their switching ability amongst various oxidation states. 45 As far as the literature is concerned, reports on simultaneous, selective optical recognition of Y 3+ and Pb 2+ are unavailable.…”