Oxovanadium (IV) Dipicolinate: Structure Nucleolytic and Anticancer Property

Abstract

Diaqua(dipicolinato)oxovanadium (IV) ethanol solvate crystallizes in the triclinic space group P1. The complex was characterized by FTIR, elemental analysis, thermal gravimetric analysis, and solution visible spectral analysis. The complex alone cleaved DNA in the absence of hydrogen peroxide and its nucleolytic efficiency is greater than that of VOSO 4 . Its nucleolytic efficiency is affected by the choice of buffer used and pH. DNA cleavage can be inhibited by DMSO, NaN 3 and catalase, implying involvement of ROS. An MTT assay, involving the lung cancer cell line PC9, gave IC 50 values of 9.5 µM and 16 µM for the complex and VOSO 4 respectively. For breast cancer cell line MCF-7, this complex is less cytotoxic, with an IC 50 of 16 µM.

Preparation of Allyl Alcohol Oligomers Using Dipicolinate Oxovanadium(IV) Coordination Compound

“…Vanadium complex compounds are used as catalysts in industrial production of synthetic rubbers, elastomers and polyethylene [31]. However, in our case, special attention was given to the dipicolinate complex of oxovanadium(IV), due to its widely described physicochemical and biological properties such as combating diabetes type I and II [32], cell metabolism [33], antioxidant properties [34], plasmid DNA cleavage, chromosomal aberrations and use in anticancer therapy [35,36]. Thorn et al have reported the application of V-dipic complexes as: [VO(dipic)(i-PrO)], [VO(dipic)(pinme)], [VO(dipic)(dpheol)] and analogs in stoichiometric aerobic oxidation of isopropanol and other alcohols as lignin models [37].…”