Oxovanadium(IV) complexes of bioinorganic and medicinal relevance: Synthesis, characterization and 3D molecular modeling of some oxovanadium(IV) complexes involving O, N-donor environment of salicylaldehyde-based sulfa drug Schiff bases

Maurya, R. C.; Chourasia, J.; Rajak, D.K.; Malik, Bashir Ahmad; Mir, Jan Mohammad; Jain, N.; Batalia, S.

doi:10.1016/j.arabjc.2011.12.012

Cited by 21 publications

(8 citation statements)

References 67 publications

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“…Spectra of the complexes also show new peaks at around 413–452 cm −1 and 493–552 cm −1 region due to the formation of M-O and M-N bands, respectively. In addition to other bands, the oxidovanadium complex shows its characteristic V=O frequency at 980 and 967 cm −1 regions for complexes 1 and 2 [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies

Savithri

Revanasiddappa

2018

Bioinorganic Chemistry and Applications

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Two novel oxidovanadium(IV) complexes with a new bidentate (O- and N-) imine-based ligand 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol (HL) were synthesized under in situ experimental condition where VOSO4 acts as a kinetic template in the ratio 2 : 1 (L : M) and mixed ligand complex using 1,10-phenanthroline (phen) in 1 : 1 : 1 (L : M : phen) ratio. The synthesized compounds were structurally characterized by microanalysis, magnetic susceptibility, FTIR, electronic spectra, TG/DTA, ESR, and molar conductance studies. Based on the spectral studies, the complexes have the general composition [VO(L)2] (C1) and [VO(L)phen] (C2) in a square pyramid geometrical fashion. The synthesized compounds were primarily screened for their in vitro growth inhibiting activity against different strains of bacteria, namely, E. coli, B. subtilis, S. aureus, and P. aeruginosa by the disc diffusion method. Also, the antifungal activity was determined against C. albicans and A. niger by the Bateman poisoned technique. The in vitro antioxidant activity of all the compounds was determined by DPPH free radical-scavenging assay. Intercalative mode of DNA-binding properties of the oxidovanadium(IV) complexes with calf-thymus DNA (CT-DNA) was investigated using UV, fluorescence spectra, and viscosity measurements.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies

Savithri

Revanasiddappa

2018

Bioinorganic Chemistry and Applications

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“…The bands observed for the complexes between 517-545 and 459-493 cm -1 were metal sensitive and are assigned to ν(M-O) and ν(M-N) respectively [19]. In addition, the oxidovanadium complexes C7 and C8 shows a band at 985 and 963 cm -1 attributed to V = O frequency [20].…”

Section: Infrared Spectramentioning

confidence: 93%

DNA binding, BSA interaction andin-vitroantimicrobial studies of Cu(II), Co(III), Ni(II) and VO(IV) complexes with a new Schiff base

Sharma

Revanasiddappa

Jayalakshmi³

2020

Egyptian Journal of Basic and Applied Sciences

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A new bidentate (E)-2-((3-(benzyloxypyridinylimino) methyl)-6-methoxyphenol (L) and its complexes such as [Cu(L) 2 ] (C1), [Cu(L)(Phen)] (C2), [Co(L) 2 ] (C3), [Co(L)(Phen)] (C4), [Ni(L) 2 ] (C5), [Ni(L)(Phen)] (C6), [VO(L) 2 ] (C7) and [VO(L) (Phen)] (C8), (L = Schiff base derived from 2-amino-3-benzyloxypyridine and 3-methoxy salicylaldehyde, Phen = 1, 10-phenanthroline) were synthesized and the prepared complexes were characterized by different analytical techniques elemental analysis, magnetic moment, molar conductance, infrared spectra, 1 H and 13 C NMR, mass, electronic absorption and Thermogravimetric Analysis (TGA). Electron Paramagnetic Resonance (EPR) spectrum of Cu(II) and VO(IV) complexes are studied. The synthesized compounds C1-C8 were primarily screened for their in vitro anti-microbial activities against gram positive, gram negative bacteria and fungi. The remarkable antimicrobial activity results from complexes C-C8. The interaction between the newly prepared ligand and Cu(II), Co(III), Ni(II) and VO(IV) complexes with calf-thymus DNA (CT-DNA) was achieved by absorption, fluorescence, and viscosity measurements. The binding of metal complexes with BSA (bovine serum albumin) was reported by the multi spectroscopic methods. The results illustrated that the C1-C8 complexes can significantly interact with the DNA via intercalation mode and a static quenching is reported for BSA. As a result of this the deformity in secondary structure of BSA occurs.

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“…New bands were observed in the metal ion complexes, but bands are not present in the spectrum of ferrocene based organometallic compound. The spectra of complexes in the range of 558-572 cm -1 , corresponding to metal-nitrogen bonding [18][19] and 412-443 cm -1 corresponding to metal-oxygen bonding respectively [20]. The appearances of vM-N and vM-O vibrations support the involvement of N and O atoms in complexation with metal ions [21][22].…”

Section: Ir Spectramentioning

confidence: 99%

Synthesis of Ferrocene Based Organometallic Compounds & Antimicrobial Activity

M¹,

Lokhande²

2014

IOSRJAC

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The synthesis, characterisation, spectral studies, antibacterial and fugal studies of some transition metal ions like Mn ++ , Co ++ , Ni ++ , Cu ++ , Pd ++ and Pt ++ complexes of ferrocene based Organometallic compounds have been reported. The coordinate bonding of nitrogen to the central metal atom which reduces the electron density in the both azomethine link and thus lower the-HC=Nabsorption. The elemental analysis data exhibit the formation of 1:1 [M: L] ratio with coordination number six in the all complexes. The complexes have with octahedral geometry and D 4 h symmetry. The ferrocene based organometallic compound shows a molecular ion peak at m/z 482.4 which is equal to theoretical molecular weight. The molar conductance value indicates that, they are non-electrolytic in nature. These complexes were tested with some bacteria and fungi.

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Oxovanadium(IV) complexes of bioinorganic and medicinal relevance: Synthesis, characterization and 3D molecular modeling of some oxovanadium(IV) complexes involving O, N-donor environment of salicylaldehyde-based sulfa drug Schiff bases

Cited by 21 publications

References 67 publications

Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies

Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies

DNA binding, BSA interaction andin-vitroantimicrobial studies of Cu(II), Co(III), Ni(II) and VO(IV) complexes with a new Schiff base

Synthesis of Ferrocene Based Organometallic Compounds & Antimicrobial Activity

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