Oxovanadium(IV) chloride complexes with purine and adenine

Mikulski, Chester M.; Cocco, Susan; Franco, Nancy De; Karayannis, Nicholas M.

doi:10.1016/s0020-1693(00)86466-x

Cited by 20 publications

(2 citation statements)

References 35 publications

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“…The participation of ligand ring nitrogens in coordination is interpreted. [1][2][3][4][5][6][7][8][9] On the other hand, the NH 2 deformation modes of free ADN are only slightly shifted in the IR spectrum of the complex indicating the non-participation of the exocyclic N(6) nitrogen of the NH 2 group in coordination.…”

Section: Infrared Studiesmentioning

confidence: 99%

Interaction of carbonylchlorohydridotris (triphenylphosphine) ruthenium (II) with purine, adenine, cytosine and cytidine

Ghose

2004

Journal of Chemical Research

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Many heavy metal ions are toxic in nature and certain complexes show antineoplastic activity. The interaction of the metal ions with DNA constituents might cause these. The biologically important nucleic acids constituents provide potential binding sites for metal ions.As a number of factors are responsible for the ability of the various donor atoms of nucleosides and nucleotides to act as sites of complexation, it is difficult to predict the binding sites for metal ions in a metal complex. The present paper deals with studies of carbonylchlorohydridotris (triphenylphosphine) ruthenium (II) complex with purine (PUR), adenine (ADN), cytosine (CTS) and cytidine (CTD). Investigations were undertaken to examine any change in the potential binding sites of the ligands which were reported for simple metal ions due to the presence of the triphenylphosphine ligands which could create steric restrants. Experimental Materials: The chemicals used were of AnalaR grade. PUR, ADN, CTS, CTD and [(C 6 H 5 ) 3 P] 3 Ru(CO)(Cl)H were obtained from Aldrich Chemicals Company, Inc., U.S.A. Solvents were dried before use. All the reactions were carried out under dry N 2 . The light petroleum used had b.p. 60-80°C.Methods: IR spectra (KBr) were recorded on a Perkin-Elmer 783 spectrometer and electronic spectra (CHCl 3 ) on a Shimadzu UV 190 spectrometer. 1 H NMR and 13 C NMR spectra were measured with a JEOL spectrometer model FX 900 FTNMR using TMS in DMSO-d 6 as internal standard.Chloride and phosphorus were estimated gravimetrically. C, H and N analyses were determined by a Perkin-Elmer model 240c elemental analyser.Preparation of complexes: All the reactions were carried out under dry dinitrogen. All the ruthenium (II) complexes were prepared by a similar procedure.The complex was prepared by the addition of the appropriate ligand suspended in 25ml methanol to a continuously stirred solution of 0.500 g [RuHCl(CO)(PPh 3 )] in 5 ml dichloromethane in 1:1 ratio under nitrogen atmosphere. The mixture was refluxed for 30 min, then allowed to cool, filtered off and the resulting solid was washed with methanol and finally with petroleum ether and dried under reduced pressure. Yields were 80-90 %.

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Section: Infrared Studiesmentioning

confidence: 99%

Interaction of carbonylchlorohydridotris (triphenylphosphine) ruthenium (II) with purine, adenine, cytosine and cytidine

Ghose

2004

Journal of Chemical Research

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“…Möglicherweise ent steht in diesem Falle eine einfache Komplexver bindung, in welcher Adenin über das N(9)-Stickstoffatom koordiniert vorliegt [6]. Es könnte sich aber auch eine polymere Spezies bilden, bei welcher die V 0 2+-Kationen über die N(7)-und N(9)-Stickstoffatome des Adenins verbrückt werden [6,7].…”

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Über die Wechselwirkung des Vanadyl(IV)-Kations mit Nucleobasen / Interaction of the Vanadyl(IV) Cation with Nucleic Bases

Williams¹,

Etcheverry²,

Baran³

1993

Zeitschrift Für Naturforschung B

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The interaction of V 02+ with the nucleic bases adenine, guanine, cytosine, thymine and uracil has been investigated spectrophotometrically in a wide pH-range and with metal to base ratios 1:1 and 1:10. Adenine, guanine and uracil interact with the cation at pH-values >5, but whereas adenine apparently coordinates through Natoms, the other two bases seem to be coordinat ed through oxygen donors.In früheren Arbeiten haben wir die Wechselwir kung des V 0 2+-Kations mit Nucleotiden unter A n wendung verschiedener physikalischen M eßm e thoden untersucht [1 -4 ]

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