Oxospirochlorins as new promising photosensitizers against priority pathogens

Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy

“…Concentrations of both drugs varied from 10 to 50 μM and as expected, higher concentrations of both drugs resulted in higher ROS generation after 1 h of sonication, although quantum yields were not given. Additionally, examination of various irradiation times (15,30,45, and 60 min respectively), shows that ROS generation increases significantly over time. In both cases, 4 was more effective SS than 3.…”

“…[25] The PDT and SDT might be combined with antibiotic therapy resulting in increased disinfection efficacy on bacterial pathogens compared to monotherapies alone. [5,[30][31][32] This multi-directional strategy may take advantage of a wide range of combinations of therapeutic compounds, such as bacterial cell membrane-targeting antibiotics, bacterial cell wall-targeting antibiotics, and bacterial protein synthesis-inhibiting antibiotics, bacterial nucleic acid synthesis-inhibiting antibiotics, multiantibiotic combinations, and various sensitizer molecules. [5] Although the results vary depending on pathogens and applied combinations, in almost all cases there is a visible synergistic effect that favors the strategy.…”

“…The inactivation of bacteria may be very effective, for instance, 2,3‐bis((4‐(3,5‐bis(hydroxymethyl))butyl)tio)tribenzoporphyrazine 2 (Figure 4) used against S. aureus represents the killing rate of over 5.9 log at a concentration of 10 μM and under low light doses [25] . The PDT and SDT might be combined with antibiotic therapy resulting in increased disinfection efficacy on bacterial pathogens compared to monotherapies alone [5,30–32] . This multi‐directional strategy may take advantage of a wide range of combinations of therapeutic compounds, such as bacterial cell membrane‐targeting antibiotics, bacterial cell wall‐targeting antibiotics, and bacterial protein synthesis‐inhibiting antibiotics, bacterial nucleic acid synthesis‐inhibiting antibiotics, multi‐antibiotic combinations, and various sensitizer molecules [5] .…”

Nanotechnology for Dentistry: Prospects and Applications

“…Simultaneously, other researchers reported high potential of PACT in inactivating a wide range of microbe species. Thus, all these promising results obtained in the inactivation of some bacterial species have inspired scientists and manufacturers to develop PACT-based bactericidal systems [ 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 ]. Antibacterial systems based on PACT, such as PAD™ (Denfotex, London, UK) and Helbo ® (HELBO Photodynamic Systems GmbH, Wels, Austria), have been introduced into dental practice.…”