Oxone®-mediated direct arylselenylation of imidazo[2,1-b]thiazoles, imidazo[1,2-a]pyridines and 1H-pyrazoles

Recent Progress in Transition Metal-Free C-Heteroatom Bond Formation by Functionalization of C-H Bond in Imidazole-Fused Heterocycles

“…In 2018, Schumacher group [40] presented an efficient oxone-mediated selenylation of imidazo derivatives with diselenides under mild transition metal-free conditions.…”

Dichalcogenides/Oxone®‐Mediated Cyclization of (Z)‐Chalcogenoenynes under Ultrasound Irradiation

“…Oxone ® (2KHSO 5 ⋅KHSO 4 ⋅K 2 SO 4 ) acts as oxidant in many selective oxidation reactions [16] and it has been used to synthesize several heterocyclic compounds by intra- [17][18][19][20][21][22][23][24] and intermolecu-lar reactions, [25][26][27][28][29] including oxidative cyclization ones. [30][31][32][33][34][35][36] Recently, our group has explored the application of this oxidant in the synthesis of organoselenium and organotellurium compounds, [37][38][39][40][41][42] such as 2,3-bis-organochalcogenyl-benzo [b] chalcogenophenes, via the electrophilic cyclization of 2functionalized selanyl-and sulfanylalkynes (Scheme 1a). [43] In parallel, cyclization of enynes represents a versatile strategy for accessing cyclic compounds, specially due to the high atom-economy and excellent functional group tolerance.…”

Ultrasound-assisted synthesis of imidazo[1,2-a]pyridines and sequential one-pot preparation of 3-selanyl-imidazo[1,2-a]pyridine derivatives

“…In recent years, the synthesis and incorporation of different groups to the imidazo [1,2-a]pyridine unity, such as halogen, 8,9 aryl, 10,11 formyl 12,13 and chalcogen [14][15][16][17][18][19] have attracted the attention of synthetic organic chemists, aiming to prospect for new drug candidates. Most of these methodologies, however, present drawbacks, such as tedious multistage synthesis and workup, the generation of large amounts of waste and a high effective cost.…”