Oxoberkedienoic acid: a new octadienoic acid derivative isolated from <i>Talaromyces verruculosus</i> using a chemical screening system

Talarolactones A–G, α-Pyrone Dimers with Anti-inflammatory Activities from Talaromyces adpressus, and Their Biosynthetic Pathways

“…1−3 Talaromyces (the sexual genus of Penicillium), a ubiquitous fungal genus generally discovered from soil, plants, sponges, and foods, have been reported to produce various specialized metabolites. 4−7 Species of Talaromyces have a wide range of applications, such as being used to produce cellulase and natural pigments in the industry, 8−11 that are found to produce abundant bioactive secondary metabolites mainly including alkaloids, meroterpenoids, polyketides, and miscellaneous structures, 12,13 some of which exhibited antimicrobial, anti-Aβ 42 aggregation, and PTP1B inhibition activities. 14,15 Therefore, the genus of Talaromyces has attracted great attention of natural product chemists.…”

“…The ultraviolet (UV) [284 nm (log ε = 3.55)] and infrared (IR) (1697 and 1572 cm −1 ) spectra demonstrated the presence of an α-pyrone moiety. 16,17 The 1 H (Table S1 of the Supporting Information) and 13 C (Table S2 of the Supporting Information) NMR data of compound 1 revealed the presence of two ester groups, six olefinic carbons, three methines, three methylenes, two methyls, and two methoxyls. Thus, besides five degrees of unsaturation occupied by these functionalities, four rings are required in the structure of compound 1.…”

“…Microorganisms are a plentiful source of structurally diverse secondary metabolites that exert a considerable impact on the control of infectious and inflammatory diseases and other medical conditions. − Talaromyces (the sexual genus of Penicillium), a ubiquitous fungal genus generally discovered from soil, plants, sponges, and foods, have been reported to produce various specialized metabolites. − Species of Talaromyces have a wide range of applications, such as being used to produce cellulase and natural pigments in the industry, − that are found to produce abundant bioactive secondary metabolites mainly including alkaloids, meroterpenoids, polyketides, and miscellaneous structures, , some of which exhibited antimicrobial, anti-Aβ 42 aggregation, and PTP1B inhibition activities. , Therefore, the genus of Talaromyces has attracted great attention of natural product chemists. As a continuation of our ongoing work for structural novel and biological active lead compounds from fungi, soil-derived Talaromyces adpressus was systematically investigated.…”