Oxitocina y autismo: una hipótesis para investigar. ¿La alteración de la producción de oxitocina endógena en torno al parto puede estar involucrada en la etiología del autismo?

Fernández, Ibone Olza; Gabriel, Miguel Ángel Marín; Sánchez, Francisco López; Martínez, Ana María Malalana

doi:10.1016/j.rpsm.2010.10.004

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Perinatal alterations of OT can also have life-long lasting effects on the development of social behaviors [124]. Within the perinatal period, various processes, like planned caesarean section, labor induced by synthetic OT or interrupted with oxytocinergic antagonists, can also alter the OT balance in the newborns, even though the implications and medium/long-term effects of these manipulations are still largely unknown [123,125].…”

Section: Perinatal/early Postnatal Periodmentioning

confidence: 99%

Risk and Protective Environmental Factors Associated with Autism Spectrum Disorder: Evidence-Based Principles and Recommendations

Gialloreti

Mazzone

Benvenuto

et al. 2019

JCM

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Autism Spectrum Disorder (ASD) is a complex condition with early childhood onset, characterized by a set of common behavioral features. The etiology of ASD is not yet fully understood; however, it reflects the interaction between genetics and environment. While genetics is now a well-established risk factor, several data support a contribution of the environment as well. This paper summarizes the conclusions of a consensus conference focused on the potential pathogenetic role of environmental factors and on their interactions with genetics. Several environmental factors have been discussed in terms of ASD risk, namely advanced parental age, assisted reproductive technologies, nutritional factors, maternal infections and diseases, environmental chemicals and toxicants, and medications, as well as some other conditions. The analysis focused on their specific impact on three biologically relevant time windows for brain development: the periconception, prenatal, and early postnatal periods. Possible protective factors that might prevent or modify an ASD trajectory have been explored as well. Recommendations for clinicians to reduce ASD risk or its severity have been proposed. Developments in molecular biology and big data approaches, which are able to assess a large number of coexisting factors, are offering new opportunities to disentangle the gene–environment interplay that can lead to the development of ASD.

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Section: Perinatal/early Postnatal Periodmentioning

confidence: 99%

Risk and Protective Environmental Factors Associated with Autism Spectrum Disorder: Evidence-Based Principles and Recommendations

Gialloreti

Mazzone

Benvenuto

et al. 2019

JCM

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“…One such perinatal factor is the administration of synthetic oxytocin during delivery (Brotaneck & Hodr, 1967;D'Esopo, 1964;Elert, 1966;Gonz alez-Valenzuela et al, 2014;Plothe, 2010;Sacrez et al, 1969;Wells, 1965). Research suggests that the use of oxytocin to induce labor may have an effect on neonatal feeding reflexes (Olza et al, 2012), on the risk of subsequent psychiatric disorders (Li et al, 2011), and on the child's psychomotor development (Elert, 1966;Sacrez et al, 1969;Wells, 1965); it has also been linked to the etiopathogenesis of autism (Olza, Mar ın, L opez, & Malalana, 2011). These findings highlight the need for specific research on the potential risks that oxytocin perfusion in labor may pose for neonatal and child development.…”

Section: Introductionmentioning

confidence: 99%

Exposure to synthetic oxytocin during delivery and its effect on psychomotor development

González-Valenzuela

López‐Montiel

González-Mesa

2015

Developmental Psychobiology

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The main objective is to examine the influence of oxytocin administration during delivery on psychomotor development at age five years. This was a retrospective cohort study involving two groups: children of mothers exposed vs. not exposed to oxytocin during labor. Of the 7,465 newborns registered in our maternity service during 2006 we randomly selected an initial sample of 400 children. Of these, 146 children were assessed using the motor scale of the Battelle Developmental Inventory. Other predictor variables that could potentially act as confounders and/or interact with the main relationship were also examined. The data were subjected to bivariate analysis, estimates of measures of strength of association, stratified analysis and multivariate binary logistic regression. The results indicate that exposure to synthetic oxytocin during delivery is an independent risk factor for a delay in gross and fine motor development. This was the case after controlling for the variables duration of labor and sex of the newborn, none of which modified the effect of oxytocin on gross and fine motor development. However, sex of the newborn were shown to be confounding gross motor development. In light of these results, and with the aim of preventing possible psychomotor alterations, further studies are now needed to analyze the effect that the oxytocin dose and the duration of perfusion may have on children's subsequent development.

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Oxytocin and Animal Models for Autism Spectrum Disorder

Wagner

Harony‐Nicolas

2017

Current Topics in Behavioral Neurosciences

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Autism spectrum disorder (ASD) is a group of complex neurodevelopmental conditions characterized by deficits in social communication and by repetitive and stereotypic patterns of behaviors, with no pharmacological treatments available to treat these core symptoms. Oxytocin is a neuropeptide that powerfully regulates mammalian social behavior and has been shown to exert pro-social effects when administered intranasally to healthy human subjects. In the last decade, there has been a significant interest in using oxytocin to treat social behavior deficits in ASD. However, little attention has been paid to whether the oxytocin system is perturbed in subgroups of individuals with ASD and whether these individuals are likely to benefit more from an oxytocin treatment. This oversight may in part be due to the enormous heterogeneity of ASD and the lack of methods to carefully probe the OXT system in human subjects. Animal models for ASD are valuable tools to clarify the implication of the oxytocin system in ASD and can help determine whether perturbation in this system should be considered in future clinical studies as stratifying biomarkers to inform targeted treatments in subgroups of individuals with ASD. In this chapter, we review the literature on genetic- and environmental-based animal models for ASD, in which perturbations in the oxytocin system and/or the effect of oxytocin administration on the ASD-associated phenotype have been investigated.

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Oxitocina y autismo: una hipótesis para investigar. ¿La alteración de la producción de oxitocina endógena en torno al parto puede estar involucrada en la etiología del autismo?

Cited by 4 publications

References 35 publications

Risk and Protective Environmental Factors Associated with Autism Spectrum Disorder: Evidence-Based Principles and Recommendations

Risk and Protective Environmental Factors Associated with Autism Spectrum Disorder: Evidence-Based Principles and Recommendations

Exposure to synthetic oxytocin during delivery and its effect on psychomotor development

Oxytocin and Animal Models for Autism Spectrum Disorder

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