Ionic cocrystals
(ICCs) of racemic RS-oxiracetam
and of its active S-enantiomer of pharmaceutical
interest with the pharmaceutically acceptable salts calcium and magnesium
chloride were synthesized and structurally characterized. The cocrystallization
of RS-oxiracetam with MgCl2 resulted in
chiral resolution with formation of an S-OXI·MgCl2·5H2O/R-OXI·MgCl2·5H2O conglomerate. Ternary phase diagrams
of RS-oxiracetam/inorganic salt/solvent were constructed
to determine the overall compositions for which the ICCs are the only
stable phases in suspension. In addition, single crystals of S-oxiracetam were grown, and its structure was determined.