Oximoaspergillimide, a Fungal Derivative from a Marine Isolate of <i>Aspergillus</i> sp.

Cardoso-Martínez, Faviola; Rosa, José M. de la; Dı́az-Marrero, Ana R.; Dárias, José; D’Croz, Luis; Cerella, Claudia; Diederich, Marc; Cueto, Mercedes

doi:10.1002/ejoc.201403668

Cited by 23 publications

(9 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no HMBC correlation from NH-10 to C-8, while correlation was observed from NH-10 to C-12 (Figure S13), suggesting that the imide motif in 1 is likely a cis-trans conformer. This observation is in agreement with those reported for imide-containing natural products that the cis-trans conformation is the most stable [29][30][31][32].…”

Section: Structure Elucidationsupporting

confidence: 93%

Targeted Isolation of Indole Alkaloids from Streptomyces sp. CT37

et al. 2020

View full text Add to dashboard Cite

Four compounds (1–4) were isolated from the extracts of Streptomyces sp. CT37 using bioassay in conjunction with mass spectrometric molecular networking (MN) driven isolation. Their complete structures were established by high-resolution electrospray ionization mass spectrometry (HR-ESIMS), and 1D and 2D nuclear magnetic resonance (NMR) data. Legonimide 1 was identified as a new alkaloid containing a rare linear imide motif in its structure, while compounds 2–4 were already known and their structures were elucidated as 1H-indole-3-carbaldehyde, actinopolymorphol B, (2R,3R)-1-phenylbutane-2,3-diol, respectively. The biosynthetic pathways of 1–4 were proposed based on the reported biogenesis of indole alkaloids in literature. Bioactivity tests for 1 and 2 revealed moderate growth inhibition activity against Candida albicans ATCC 10231 with MIC95 values of 21.54 µg/mL and 11.47 µg/mL, respectively.

show abstract

Section: Structure Elucidationsupporting

confidence: 93%

Targeted Isolation of Indole Alkaloids from Streptomyces sp. CT37

et al. 2020

View full text Add to dashboard Cite

show abstract

“…179 cultured in liquid media resulted in incorporation into versicolamide B and also into seven new metabolites 185-191, which were not produced under normal culture conditions. The same incorporation experiment on agar medium resulted in production of four additional new metabolites, [192][193][194][195]. All were produced as racemic mixtures.…”

Section: Marine-sourced Fungi (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2017

View full text Add to dashboard Cite

Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

show abstract

“…Twenty-four novel alkaloid-bioactive compounds (25-48; Figure 2) have been reported from deep-sea fungi since 2013, out of which compounds 25-40 were isolated from Penicillium spp., and showed cytotoxic activities against BV2 cell (IC50 of 27-45 µ g/mL), brine shrimp (IC50 of 14.1 to 38.5 µ g/mL), SMMC-7721 (IC50 of 54.2 µ M), BEL-7402 ((IC50 of 17.5 µ M), and BEL-7402 (IC50 of 19.8 µ M) [19][20][21]. Compounds 41-46 were identified from Aspergillus spp., in which compounds 41 and 45-46 displayed antibiotic activity (MIC of 30 to 40 µ g/mL) against BCG, Candida albicans, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus cereus, Klebsiella pneumoniae, and Escherichia…”

Section: Nitrogen-containing Compoundsmentioning

confidence: 99%

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Arifeen

Xue

et al. 2019

Marine Drugs

View full text Add to dashboard Cite

Growing microbial resistance to existing drugs and the search for new natural products of pharmaceutical importance have forced researchers to investigate unexplored environments, such as extreme ecosystems. The deep-sea (>1000 m below water surface) has a variety of extreme environments, such as deep-sea sediments, hydrothermal vents, and deep-sea cold region, which are considered to be new arsenals of natural products. Organisms living in the extreme environments of the deep-sea encounter harsh conditions, such as high salinity, extreme pH, absence of sun light, low temperature and oxygen, high hydrostatic pressure, and low availability of growth nutrients. The production of secondary metabolites is one of the strategies these organisms use to survive in such harsh conditions. Fungi growing in such extreme environments produce unique secondary metabolites for defense and communication, some of which also have clinical significance. Despite being the producer of many important bioactive molecules, deep-sea fungi have not been explored thoroughly. Here, we made a brief review of the structure, biological activity, and distribution of secondary metabolites produced by deep-sea fungi in the last five years.

show abstract

Oximoaspergillimide, a Fungal Derivative from a Marine Isolate of Aspergillus sp.

Abstract: A new alkaloid, oximoaspergillimide (1), and the known neohydroxyaspergillic (2) and neoaspergillic (3) acids, have been isolated from the extract of a cultured marine-derived fungus (strain CF07002) identified as a member of the genus Asper-

Cited by 23 publications

References 39 publications

Targeted Isolation of Indole Alkaloids from Streptomyces sp. CT37

Targeted Isolation of Indole Alkaloids from Streptomyces sp. CT37

Marine natural products

Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules

Contact Info

Product

Resources

About