Oxigenación de músculos respiratorios y locomotores durante el test cardiopulmonar en pacientes con circulación de Fontan: serie de casos

Contreras-Briceño, Felipe; Valderrama, Paulo; Moya, Eduardo; Espinosa, Marisol; Villaseca, Yenny; Ira-Ira, Cinthya; Moya, A. Gonzalez; Mieres, Jocelyn; Clavería, Cristián

doi:10.4067/s0718-85602021000100027

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“…In studies with exercise as part of the experimental protocol, optical wearable biosensors with NIRS technology have been positioned mainly in locomotor muscles (e.g., m.vastus lateralis, m.tibialis anterior, and m.gastrocnemius) [32,33] to identify effort intensity. Our research group has examined the changes in SmO 2 in RMs (m.intercostales) and m.vastus lateralis during an incremental exercise in athletes [22,34,35], untrained subjects [36], and patients with Fontan circulation [37], showing a consistent inverse association between a drop in SmO 2 -m.intercostales (∇SmO 2 -m.intercostales) and increased ventilatory variables, aspects more notorious at moderate-to-high exercise intensities, where to compensate for the metabolic acidosis, the respiratory system demand boosts exponentially.…”

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confidence: 99%

Monitoring Changes in Oxygen Muscle during Exercise with High-Flow Nasal Cannula Using Wearable NIRS Biosensors

Contreras-Briceño,

Espinosa-Ramírez,

Rivera-Greene

et al. 2023

Biosensors

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Exercise increases the cost of breathing (COB) due to increased lung ventilation (V˙E), inducing respiratory muscles deoxygenation (∇SmO2), while the increase in workload implies ∇SmO2 in locomotor muscles. This phenomenon has been proposed as a leading cause of exercise intolerance, especially in clinical contexts. The use of high-flow nasal cannula (HFNC) during exercise routines in rehabilitation programs has gained significant interest because it is proposed as a therapeutic intervention for reducing symptoms associated with exercise intolerance, such as fatigue and dyspnea, assuming that HFNC could reduce exercise-induced ∇SmO2. SmO2 can be detected using optical wearable devices provided by near-infrared spectroscopy (NIRS) technology, which measures the changes in the amount of oxygen bound to chromophores (e.g., hemoglobin, myoglobin, cytochrome oxidase) at the target tissue level. We tested in a study with a cross-over design whether the muscular desaturation of m.vastus lateralis and m.intercostales during a high-intensity constant-load exercise can be reduced when it was supported with HFNC in non-physically active adults. Eighteen participants (nine women; age: 22 ± 2 years, weight: 65.1 ± 11.2 kg, height: 173.0 ± 5.8 cm, BMI: 21.6 ± 2.8 kg·m−2) were evaluated in a cycle ergometer (15 min, 70% maximum watts achieved in ergospirometry (V˙O2-peak)) breathing spontaneously (control, CTRL) or with HFNC support (HFNC; 50 L·min−1, fiO2: 21%, 30 °C), separated by seven days in randomized order. Two-way ANOVA tests analyzed the ∇SmO2 (m.intercostales and m.vastus lateralis), and changes in V˙E and ∇SmO2·V˙E−1. Dyspnea, leg fatigue, and effort level (RPE) were compared between trials by the Wilcoxon matched-paired signed rank test. We found that the interaction of factors (trial × exercise-time) was significant in ∇SmO2-m.intercostales, V˙E, and (∇SmO2-m.intercostales)/V˙E (p < 0.05, all) but not in ∇SmO2-m.vastus lateralis. ∇SmO2-m.intercostales was more pronounced in CTRL during exercise since 5′ (p < 0.05). Hyperventilation was higher in CTRL since 10′ (p < 0.05). The ∇SmO2·V˙E−1 decreased during exercise, being lowest in CTRL since 5′. Lower dyspnea was reported in HFNC, with no differences in leg fatigue and RPE. We concluded that wearable optical biosensors documented the beneficial effect of HFNC in COB due to lower respiratory ∇SmO2 induced by exercise. We suggest incorporating NIRS devices in rehabilitation programs to monitor physiological changes that can support the clinical impact of the therapeutic intervention implemented.

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Section: Introductionmentioning

confidence: 99%

Monitoring Changes in Oxygen Muscle during Exercise with High-Flow Nasal Cannula Using Wearable NIRS Biosensors

Contreras-Briceño,

Espinosa-Ramírez,

Rivera-Greene

et al. 2023

Biosensors

Self Cite

View full text Add to dashboard Cite

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Oxigenación de músculos respiratorios y locomotores durante el test cardiopulmonar en pacientes con circulación de Fontan: serie de casos

Abstract: Oxigenación de músculos respiratorios y locomotores durante el test... Contreras-Briceño Felipe., et al.

Cited by 1 publication

References 23 publications

Monitoring Changes in Oxygen Muscle during Exercise with High-Flow Nasal Cannula Using Wearable NIRS Biosensors

Monitoring Changes in Oxygen Muscle during Exercise with High-Flow Nasal Cannula Using Wearable NIRS Biosensors

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