Oxidovanadium(V) amine bisphenolates as epoxidation, sulfoxidation and catechol oxidation catalysts

The liposomal delivery of hydrophobic oxidovanadium complexes imparts highly effective cytotoxicity and differentiating capacity in neuroblastoma tumour cells

“…We have previously prepared a series of amine bisphenol oxidovanadium complexes (AL2-AL4 in Fig. 1), which are highly insoluble in aqueous solutions [37][38][39] . A salan complex AL1 is also highly insoluble in water 38 .…”

“…1 ), which are highly insoluble in aqueous solutions 37 – 39 . A salan complex AL1 is also highly insoluble in water 38 . While analogous to iso-propanolate derivative L 7 VO(OiPr), which had previously been shown to have little cytotoxicity in OVCAR01 or HT29 tumour cells 40 , we wished to assess AL1 in neuroblastoma cells.…”

“…BMOV was from ORGANICA Feinchemie GmbH Wolfen, Germany. Complexes AL1-4 and their ligands were synthesised as described previously [37][38][39] . The solubility of these complexes in water is negligible as measured by spectroscopic (UV, 51 V NMR) methods.…”

“…Since BMOV is water soluble and not particularly stable in aqueous environments, our aim was to identify alternative, hydrophobic oxidovanadium complexes and to demonstrate for the first time their cytotoxicity in neuroblastoma tumour cells when delivered with liposomes. Here we demonstrate this approach using a class of highly hydrophobic V(V) complexes with aminoalcohol bisphenol and salan ligands that we have described previously [37][38][39] . Our data confirm the cytotoxicity and differentiating capacity of each compound in several neuroblastoma cell lines and, moreover, we successfully deliver one of these complexes to cultured neuroblastoma tumour cells using liposomes, where it retains good bioavailability and efficacy.…”

Dichiral [4.4.3.01,5]tridecane copper(II) cluster derived from a tripodal ligand having unsymmetrical podands and the linker: Synthesis, structure, surface grafting and catalytic aspects

“…The most recent contribution of bisphenolate armed [4.4.3.0 1,5 ]tridecane metallatranes as reaction mediators includes copolymerization reactions of CO 2 and cyclohexene oxide, polymerization of methacrylate, hydrophosphination of alkenes, alkynes and heterocumulenes, ring-opening polymerization of L-lactic acid, o-carboxy anhydrides and L-lactide, epoxidation, sulfoxidation and catechol oxidation and cycloaddition of epoxides. [12][13][14][15][16][17][18][19][20][21][22][23][24] The metal centres of metallatrane catalysts are widely distributed among various elements, that is, s-block (K), p-block (Al), d-block (Ti, Zr, Zn, Cr, V, Mo, W) and f-block elements (Y, Yb, Nd, La, Sm). Although bisphenolate atranes of Fe(III), Co(III), Cu(II), Si(IV) and Sn(IV) are known; however, their use in catalysis is rarely reported.…”