Óxido nítrico: ¿un posible nuevo biomarcador en insuficiencia cardíaca? Relación con hipertensión pulmonar secundaria a insuficiencia cardíaca izquierda

Bonafede, Roberto Jorge; Calvo, Juan Pablo; Fausti, Julia María Valeria; Puebla, Sonia; Gambarte, Adolfo Juan; Manucha, Walter

doi:10.1016/j.arteri.2016.12.002

Cited by 5 publications

(1 citation statement)

References 10 publications

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“…Установлено, что мембранный потенциал митохондрий кардиомиоцитов крыс при хронической сердечной недостаточности достоверно снижается [22]. Причиной дисфункции митохондрий при экспериментальной ХСН является окислительный стресс, о развитии которого свидетельствует увеличение концентрации МДА в митохондриях кардиомиоцитов и снижение суммарной активности СОД, что согласуется с литературными данными [23].…”

Section: методикаunclassified

Influence of the dense extract from herb of Primula veris L. On the oxidative stress development and the functional state of the cardiomyocytes mitochondria of rats with experimental chronic heart failure

et al. 2018

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Experimental chronic heart failure (CHF), caused by administration of L-isoproterenol (2.5 mg/kg twice a day intraperitoneally for 21 days), promotes uncoupling of respiration and oxidative phosphorylation. The rate of mitochondrial oxygen consumption in the metabolic state V3 by Chance in animals with CHF decreased by 53.3% (p<0.05) with malate using (as an oxidation substrate feeding сomplex I of the electron transport chain (ETC)), by 70.6% (p<0.05) with succinate using (сomplex II substrate) and by 63.6% (p<0.05) when malate and succinate were added simultaneously. The respiratory control ratio significantly decreased 2.3 times for сomplex I, 2.5 for сomplex II, and 2.6 times for the simultaneous operation of two respiratory chain complexes in mitochondria of CHF rats compared to intact animals. Mitochondrial dysfunction in experimental CHF is evidently due to the development of oxidative stress. It was revealed that the content of malonic dialdehyde (MDA) in the group of rats with experimental CHF was higher by 54.7% (p<0.05), as compared with intact animals. The activity of superoxide dismutase (SOD) and catalase was lower by 17.5% (p<0.05), and by 18.4%, respectively than in the intact group. The dense extract from herba of Primula veris L. (DEHPV) 30 mg/kg limits the development of mitochondrial dysfunction in rats with experimental CHF, as evidenced by an increase in the role of V3 respiration for the first and second respiratory chain complexes in 1.7 (p<0.05) and 2.0 times (p<0.05), respectively, the ratio of respiratory control (RCR) - 1.7 times (p<0.05) for сomplex I and 2 times (p<0.05) for сomplex II compared with the negative control. The concentration of MDA was by 15.7% (p<0.05), lower and the activity of SOD was by 56.3% (p<0.05) higher.

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Section: методикаunclassified

Influence of the dense extract from herb of Primula veris L. On the oxidative stress development and the functional state of the cardiomyocytes mitochondria of rats with experimental chronic heart failure

et al. 2018

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Nitric oxide: A possible new biomarker in heart failure? Relationship with pulmonary hypertension secondary to left heart failure

Lahera

2017

Clínica e Investigación en Arteriosclerosis (English Edition)

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Nitric oxide and related factors linked to oxidation and inflammation as possible biomarkers of heart failure

Bonafede

Manucha

2018

Clínica e Investigación en Arteriosclerosis (English Edition)

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Óxido nítrico: ¿un posible nuevo biomarcador en insuficiencia cardíaca? Relación con hipertensión pulmonar secundaria a insuficiencia cardíaca izquierda

Cited by 5 publications

References 10 publications

Influence of the dense extract from herb of Primula veris L. On the oxidative stress development and the functional state of the cardiomyocytes mitochondria of rats with experimental chronic heart failure

Influence of the dense extract from herb of Primula veris L. On the oxidative stress development and the functional state of the cardiomyocytes mitochondria of rats with experimental chronic heart failure

Nitric oxide: A possible new biomarker in heart failure? Relationship with pulmonary hypertension secondary to left heart failure

Nitric oxide and related factors linked to oxidation and inflammation as possible biomarkers of heart failure

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