Oxidized starch cross-linked porous collagen-based hydrogel for spontaneous agglomeration growth of adipose-derived stem cells

Xie, Xiaohua; Li, Xinying; Lei, Jinfeng; Zhao, Xi; Lyu, Yongbo; Mu, Changdao; Li, Defu; Ge, Liming; Xu, Yongbin

doi:10.1016/j.msec.2020.111165

Cited by 18 publications

(12 citation statements)

References 47 publications

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“…Collagen, sodium hyaluronate, and nanohydroxyapatite are biocompatible materials, and the biomaterials made from them have been testified to display a low hemolysis ratio. Figure B shows that the hemolysis ratios of all scaffolds are about 3%, which is lower than the national standard of 5% for medical biological materials . Therefore, the multilayer scaffolds supply the demand of blood compatibility in medical biological materials.…”

Section: Resultsmentioning

confidence: 87%

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Mimicking the Composition and Structure of the Osteochondral Tissue to Fabricate a Heterogeneous Three-Layer Scaffold for the Repair of Osteochondral Defects

Zhou

Long

et al. 2022

ACS Appl. Bio Mater.

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Heterogeneous three-layer scaffolds were fabricated by mimicking the biochemical composition and structure of the hyaline cartilage, calcified cartilage, and subchondral bone of the osteochondral tissue for the repair of osteochondral defects. The hyaline cartilage layer was composed of collagen I (50.0 wt %) and sodium hyaluronate (50.0 wt %). The calcified cartilage layer and subchondral bone layer were composed of collagen I, sodium hyaluronate, and nanohydroxyapatite with different proportions. N-Hydroxysuccinimide/N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride was used to mediate the crosslinking reaction of the amine groups of collagen with carboxyl groups of sodium hyaluronate. The hyaline cartilage layer and calcified cartilage layer were designed as dense structures, while the subchondral bone layer was designed as a relatively loose structure by adjusting the crosslinking degree. The scaffolds displayed a uniform and interconnected porous structure and possessed a high porosity over 85%, which were conducive to cellular adhesion and proliferation. The scaffolds could remain at 50−75% after 30 days of degradation owing to crosslinking, providing enough time for the regeneration of the osteochondral tissue. Especially, the hyaline cartilage layer and calcified cartilage layer preferred to induce the proliferation of chondrocytes, while the subchondral bone layer was more conducive to the proliferation of osteoblasts. In conclusion, the heterogeneous multilayer scaffolds could serve as implant materials for osteochondral reconstruction.

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Section: Resultsmentioning

confidence: 87%

“…Figure 8B shows that the hemolysis ratios of all scaffolds are about 3%, which is lower than the national standard of 5% for medical biological materials. 41 Therefore, the multilayer scaffolds supply the demand of blood compatibility in medical biological materials.…”

Section: Preparation and Structuralmentioning

confidence: 99%

Mimicking the Composition and Structure of the Osteochondral Tissue to Fabricate a Heterogeneous Three-Layer Scaffold for the Repair of Osteochondral Defects

Zhou

Long

et al. 2022

ACS Appl. Bio Mater.

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“…Oxidized starch has the characteristics of low viscosity, high stability, transparency, film formation, and viscosity, and is widely used in the pharmaceutical industry [ 91 ]. Using oxidized starch as a cross-linking agent, the gelation time and pore size of porous collagen-based hydrogels can be controlled by adjusting the degree of oxidation of starch, which is conducive to the aggregation and growth of adipose stem cells (ASCs), thereby inducing the secretion of VEGF and FGF-2 and promoting angiogenesis [ 92 ]. The oxidized starch/ZnO nanocomposite hydrogels prepared by Hassan et al show good swelling ability and antibacterial properties and have the potential to be used in biomedicine [ 93 ].…”

Section: Biomaterials For Preparing Hydrogelsmentioning

confidence: 99%

Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Liang

et al. 2021

Life

134

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Wounds have become one of the causes of death worldwide. The metabolic disorder of the wound microenvironment can lead to a series of serious symptoms, especially chronic wounds that bring great pain to patients, and there is currently no effective and widely used wound dressing. Therefore, it is important to develop new multifunctional wound dressings. Hydrogel is an ideal dressing candidate because of its 3D structure, good permeability, excellent biocompatibility, and ability to provide a moist environment for wound repair, which overcomes the shortcomings of traditional dressings. This article first briefly introduces the skin wound healing process, then the preparation methods of hydrogel dressings and the characteristics of hydrogel wound dressings made of natural biomaterials and synthetic materials are introduced. Finally, the development prospects and challenges of hydrogel wound dressings are discussed.

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“…Previous studies showed that starch-based films, scaffolds, and hydrogels are able to promote adhesion, [60,61] proliferation, [62,63] and differentiation. [64,65] Starch-based scaffolds with tapioca starch, for example, had a considerable impact on C2C12 myoblast cell bioactivity and promoted in vitro myogenic development. By increasing the starch content in composite scaffolds while maintaining the porous and sticky properties, the proliferation and differentiation of C2C12 cells, as well as cell dispersion inside the scaffolds, were promoted.…”

Section: Introductionmentioning

confidence: 99%

Design and Investigation of an Eco‐Friendly Wound Dressing Composed of Green Bioresources‐ Soy Protein, Tapioca Starch, and Gellan Gum

Lin

Chuang

et al. 2022

Macromolecular Bioscience

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In the fields of biomedicine and tissue engineering, natural polymer-based tissue-engineered scaffolds are used in multiple applications. As a plant-derived polymer, soy protein, containing multiple amino acids, is structurally similar to components of the extra-cellular matrix (ECM) of tissues. It is biological safety provided a good potential to be material for pure natural scaffolds. Moreover, as a protein, the properties of soy protein can be easily adjusted by modifying the functional groups on it. In addition, by blending soy protein with other synthetic and natural polymers, the mechanical characteristics and bioactive behavior of scaffolds can be facilitated for a variety of bio-applications. In this research, soy protein and polysaccharides tapioca starch are used, and gellan gum to develop a protein-based composite scaffold for cell engineering. The morphology and surface chemical composition are characterized via micro-computed tomography (micro-CT), scanning electron microscope (SEM), and fourier-transform infrared (FTIR) spectroscopy. The soy/tapioca/gellan gum (STG) composite scaffolds selectively help the adhesion and proliferation of L929 fibroblast cells while improving the migration of L929 fibroblast cells in STG composite scaffolds as the increase of soy protein proportion of the scaffold. In addition, STG composite scaffolds show great potential in the wound healing model to enhance rapid epithelialization and tissue granulation.

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Oxidized starch cross-linked porous collagen-based hydrogel for spontaneous agglomeration growth of adipose-derived stem cells

Cited by 18 publications

References 47 publications

Mimicking the Composition and Structure of the Osteochondral Tissue to Fabricate a Heterogeneous Three-Layer Scaffold for the Repair of Osteochondral Defects

Mimicking the Composition and Structure of the Osteochondral Tissue to Fabricate a Heterogeneous Three-Layer Scaffold for the Repair of Osteochondral Defects

Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Design and Investigation of an Eco‐Friendly Wound Dressing Composed of Green Bioresources‐ Soy Protein, Tapioca Starch, and Gellan Gum

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